Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

Microbiological Profile with Antibiotic Sensitivity Pattern for Chronic Suppurative Otitis Media in a Tertiary Hospital, Indonesia


Affiliations
1 Doctoral Program, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Pacar Kembang, Tambaksari, Surabaya, Jawa Timur 60132,, Indonesia
2 Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga, Dr Soetomo General Academic Hospital. Jl. Mayjen Prof. Dr. Moestopo No.6-8, Airlangga, Gubeng, Surabaya, Jawa Timur 60286,, Indonesia
3 Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Brawijaya, Veteran Malang Road, Malang, Jawa Timur 65145,, Indonesia
     

   Subscribe/Renew Journal


Introduction: Chronic suppurative otitis media (CSOM) is a chronic inflammation in the middle ear and mastoid space that repeatedly secretes through the perforated membrane of tympanic disease over three months. This disease is a critical cause of hearing in developing countries. The prevalence of CSOM in Indonesia is 3.8%. Improper use of antibiotics leads to germicidal incidence. Understanding the pattern of germs and their antibiotic sensitivity will lead to a rational choice of antibiotics to prevent the emergence of resistance. Aim: to report the microbiological profile and sensitivity patterns in CSOM patients in our department. Materials and Methods: This is a retrospective descriptive study conducted on 45 patients from September 2019 - March 2020 at the ENT-KL Department of Dr Soetomo Surabaya Indonesia. Forty-five samples were collected from CSOM patients who underwent mastoidectomy. Specimens were collected from these patients, examination, isolation, examination and isolation antibiogram were carried out according to standard procedures. Results: A total of 45 samples were obtained from this study, and all (57.77%) of the patients were identified as CSOM cases with cholesteatoma. The number of women is 62.3% more than men, and the age group 12 to 16 (20.0%) is the most reported. There were 75.6% perforations in the tympanic membrane, and a central perforation was primarily found (35.6%). Most of the Schuller mastoid X-ray results showed sclerotic features in 29 patients (59.2%). Of the 45 ear swabs, about 68.89% of the surgical materials gave positive culture results, the remaining 31.11%. There was no microbial growth, where most of the growth of monomicrobial bacteria (57.8%). Of the isolates that grew, 70.58% were identified as the group of gram-negative bacteria, with Pseudomonas Aerogenosa isolates being the most common (44.11%). Conclusion: The sensitivity test showed the most sensitivity to Meropenam, Amikacin, Piperacillin-Tazobactam, Ceftasidim and Cefoperazone-Sulbactam Cefotaxime and Ceftriaxone showed lower sensitivity.

Keywords

Chronic Suppurative Otitis Media, Sensitivity, Pseudomonas Aeroginosa, Infected, Human and Disease.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Ghogare H, Vitore V, Hatkar S, Bhalchandra MH, Wyawhare AS, Bansal VP. Microbiological Profile of Chronic Suppurative Otitis Media. Int J Curr Microbiol App Sci. 2018;7(10):1152–9.

  • Arts HA, Neely JG. Intratemporal and intracranial complications of otitis media. Head neck surgery-otolaryngology Philadelphia Lippincott Williams Wilkins. 2014;2399–409.

  • Yorgancilar E, Akkus Z, Gun R, Yildirim M, Bakir S, Kinis V, et al. Temporal bone erosion in patients with chronic suppurative otitis media. B-ENT. 2013;9(1):17–22.

  • Acuin J, World Health Organization (WHO). Chronic suppurative otitis media : burden of illness and management options. Geneva. 2004;

  • Juyal D, Sharma M, Negi V, Prakash R, Sharma N. Pseudomonas aeruginosa and its sensitivity spectrum in chronic suppurative otitis media: A study from Garhwal hills of Uttarakhand State, India. Indian J Otol. 2017;23(3):180.

  • Schilder AGM, Chonmaitree T, Cripps AW, Rosenfeld RM, Casselbrant ML, Haggard MP, et al. Otitis media. Nat Rev Dis Prim. 2016 Sep;2(1):16063.

  • Lisa AN, Wibawa FS. Karakteristik Penderita Otitis Media Supuratif Kronis (Omsk) Di Poliklinik Tht-Kl Rsud Dr. H. Abdul Moeloek Bandar Lampung Periode Januari 2013-Desember 2014. 2014.

  • Lisa A., Wibawa F. Karakteristik Penderita Otitis Media Supuratif Kronis (OMSK) Di Poliklinik THT-KL RSUD DR. H. ABDUL MOELOEK Bandar Lampung Periode Januari 2013-Desember 2014. J Chem Inf Model. 2019;53(9):1689–99.

  • Mofatteh MR, Moghaddam FS, Yousefi M, Namaei MH. A study of bacterial pathogens and antibiotic susceptibility patterns in chronic suppurative otitis media. J Laryngol Otol. 2018;132(1):41–5.

  • Viswanatha B. Microbiology of Chronic Suppurative Otitis Media: A Prospective Study in a Tertiary Care Hospital. J Otolaryngol Res. 2017;9(1):1–4.

  • Asroel HA, Siregar DR, Aboet A. Profil of Patient with Chronic Suppurative Otitis Media. J Kesehat Masy Nas. 2010;7(17):567–71.

  • Hafizah H, Qamariah N, Budiarti LY. Perbandingan sensitivitas bakteri aerob penyebab otitis media supuratif kronik tipe benigna aktif tahun 2008 dan 2012. Berk Kedokt. 2016;9(1):75–83.

  • Abraham ZS, Ntunaguzi D, Kahinga AA, Mapondella KB, Massawe ER, Nkuwi EJ, et al. Prevalence and etiological agents for chronic suppurative otitis media in a tertiary hospital in Tanzania. BMC Res Notes. 2019;12(1):429.

  • Harshika YK, Sangeetha S, Prakash R. Microbiological profile of CSOM and their antibiotic sensitivity pattern in a tertiary care hospital. Int J Curr Microbiol App Sci. 2015;4(12):735–43.

  • Tiedt NJ, Butler IRT, Hallbauer UM, Atkins MD, Elliott E, Pieters M, et al. Paediatric chronic suppurative otitis media in the Free State Province: Clinical and audiological features. South African Med J. 2013;103(7):467–70.

  • Bauer AW. Antibiotic susceptibility testing by a standardized single disc method. Am J clin pathol. 1966;45:149–58.

  • Mittal R, Lisi C V, Gerring R, Mittal J, Mathee K, Narasimhan G, et al. Current concepts in the pathogenesis and treatment of chronic suppurative otitis media. J Med Microbiol. 2015;64(Pt 10):1103.

  • Dewi PCS, Ahadiah TH, Ekorini HM. Perbandingan bone conduction pada penderita otitis media supuratif kronik dengan kolesteatoma dan tanpa kolesteatoma. Oto Rhino Laryngol Indones. 2018;48(1):18–25.

  • Haidar H, Sheikh R, Larem A, Elsaadi A, Abdulkarim H, Ashkanani S, et al. Ossicular chain erosion in chronic suppurative otitis media. Otolaryngol (Sunnyvale). 2015;5(203):2.

  • Kumara A, Nigam R, Jain AK. Chronic suppurative otitis media: A clinicopathological study at a tertiary care hospital. IJAR. 2015;1(10):235–40.

  • Veeranjaneyulu P, Kumar YA, Anisha KR, Devi PK. Clinicopathological correlation in chronic suppurative otitis media. J Clin Diagnostic Res. 2017;11(11):MC01–4.

  • Prakash R, Juyal D, Negi V, Pal S, Adekhandi S, Sharma M, et al. Microbiology of chronic suppurative otitis media in a tertiary care setup of Uttarakhand state, India. N Am J Med Sci. 2013;5(4):282.

  • Roy A, Deshmukh PT, Patil C. Pneumatization pattern in squamousal type of chronic otitis media. Indian J Otolaryngol Head Neck Surg. 2015;67(4):375–80.

  • Masdarinah A. Hubungan Lama Sakit dengan Tipe Pneumatisasi Mastoid Penderita Otitis Media Supurative Kronik. Medica Hosp J Clin Med. 2016;4(1).

  • Sunitha M, Asokan L, Sambandan AP. A comparative study of plain x-ray mastoids with HRCT temporal bone in patients with chronic suppurative otitis media. J Evol Med Dent Sci. 2015;4(30):5190–8.

  • Poorey VK. Study of bacterial flora in CSOM and its clinical significance. Indian J Otolaryngol Head neck Surg. 2002;54(2):91–5.

  • Ferede D, Geyid A, Lulseged S, Melaku A. Drug susceptibility pattern of bacterial isolates from children with chronic suppurative otitis media. Ethiop J Heal Dev. 2001;15(2).

  • Kumar D, Agrawal A, Kumar S, Gupta N. “ A Study of the Microbiological Profile of CSOM in A Tertiary Care Centre of North India .” 2019;18(5):20–4. 29. Gellatly SL, Hancock REW. Pseudomonas aeruginosa: new insights into pathogenesis and host defenses. Pathog Dis. 2013;67(3):159–73.

  • Gül HC, Kurnaz A, Turhan V, Oncül O, Pahsa A. Microorganisms isolated from middle ear cultures and their antibacterial susceptibility in patients with chronic suppurative otitis media. Kulak burun bogaz Ihtis Derg KBB= J ear, nose, throat. 2006;16(4):164–8.

  • Abraham ZS, Ntunaguzi D, Kahinga AA, Mapondella KB, Massawe ER, Nkuwi EJ, et al. Prevalence and etiological agents for chronic suppurative otitis media in a tertiary hospital in Tanzania. BMC Res Notes [Internet]. 2019 Dec 17 [cited 2019 Sep 24];12(1):429. Available from: https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-019-4483-x

  • Mohammed EH, Zimam EH. Synthesis Characterization and Studying Antibacterial Activity of some New Pyrazol Derivatives. Research Journal of Pharmacy and Technology. 2021 Jul 1;14(7):3905-10.


Abstract Views: 135

PDF Views: 0




  • Microbiological Profile with Antibiotic Sensitivity Pattern for Chronic Suppurative Otitis Media in a Tertiary Hospital, Indonesia

Abstract Views: 135  |  PDF Views: 0

Authors

Artono
Doctoral Program, Faculty of Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Pacar Kembang, Tambaksari, Surabaya, Jawa Timur 60132,, Indonesia
Rahmi Surayya
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga, Dr Soetomo General Academic Hospital. Jl. Mayjen Prof. Dr. Moestopo No.6-8, Airlangga, Gubeng, Surabaya, Jawa Timur 60286,, Indonesia
Nyilo Purnami
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Airlangga, Dr Soetomo General Academic Hospital. Jl. Mayjen Prof. Dr. Moestopo No.6-8, Airlangga, Gubeng, Surabaya, Jawa Timur 60286,, Indonesia
Edi Handoko
Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine, Universitas Brawijaya, Veteran Malang Road, Malang, Jawa Timur 65145,, Indonesia

Abstract


Introduction: Chronic suppurative otitis media (CSOM) is a chronic inflammation in the middle ear and mastoid space that repeatedly secretes through the perforated membrane of tympanic disease over three months. This disease is a critical cause of hearing in developing countries. The prevalence of CSOM in Indonesia is 3.8%. Improper use of antibiotics leads to germicidal incidence. Understanding the pattern of germs and their antibiotic sensitivity will lead to a rational choice of antibiotics to prevent the emergence of resistance. Aim: to report the microbiological profile and sensitivity patterns in CSOM patients in our department. Materials and Methods: This is a retrospective descriptive study conducted on 45 patients from September 2019 - March 2020 at the ENT-KL Department of Dr Soetomo Surabaya Indonesia. Forty-five samples were collected from CSOM patients who underwent mastoidectomy. Specimens were collected from these patients, examination, isolation, examination and isolation antibiogram were carried out according to standard procedures. Results: A total of 45 samples were obtained from this study, and all (57.77%) of the patients were identified as CSOM cases with cholesteatoma. The number of women is 62.3% more than men, and the age group 12 to 16 (20.0%) is the most reported. There were 75.6% perforations in the tympanic membrane, and a central perforation was primarily found (35.6%). Most of the Schuller mastoid X-ray results showed sclerotic features in 29 patients (59.2%). Of the 45 ear swabs, about 68.89% of the surgical materials gave positive culture results, the remaining 31.11%. There was no microbial growth, where most of the growth of monomicrobial bacteria (57.8%). Of the isolates that grew, 70.58% were identified as the group of gram-negative bacteria, with Pseudomonas Aerogenosa isolates being the most common (44.11%). Conclusion: The sensitivity test showed the most sensitivity to Meropenam, Amikacin, Piperacillin-Tazobactam, Ceftasidim and Cefoperazone-Sulbactam Cefotaxime and Ceftriaxone showed lower sensitivity.

Keywords


Chronic Suppurative Otitis Media, Sensitivity, Pseudomonas Aeroginosa, Infected, Human and Disease.

References