Research Journal of Pharmacy and Technology

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Effect of Natural/ Synthetic Polymers and Super Disintegrants on the Formulation of Zafirlukast Fast Dissolving Film


Affiliations
1 Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad,, Iraq
2 Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq., Iraq
3 Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad,, Iraq
     

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Fast-dissolving films are one of the interested delivery systems for oral solid dosage forms to overcome swallowing difficulty for geriatric and pediatric patients. Zafirlukast (ZLK) is one of the most commonly used oral medication for treatment of asthmatic patients particularly mild to moderate cases. Oral fast dissolving films of ZLK were prepared using two different filming forming polymers, hydroxypropyl methylcellulose (HPMC) and sodium carboxymethyl cellulose (SCMC). Different concentrations of the 2 polymers were used to prepare 10 formulas. Other excipients were also added at various ratios to produce 10 different formulations. These were maltodextrin, crosspivodone, polyvinylpyrrolidone (PVP), and banana powder. In vitro characterization of the formulations showed that HPMC-based formulations had significantly shorter disintegrating times (p < 0.05) and improved dissolution rates. Addition of crosspovidone, PVP, and maltodextrin as disintegrants to the film forming polymers did not significantly enhance the disintegration of the films. However, banana powder significantly elongated the film disintegration. Compatibility studies using FTIR did not show an interaction between ZLK and excipients in all formulations.

Keywords

Oral Solid Dosage Form, Formulation, Fast-Dissolving Film, Zafirlukast, Filming Forming Polymer.
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  • Zhao Y, Quan P, Fang L. Preparation of an oral thin film containing meclizine hydrochloride: in vitro and in vivo evaluation. International Journal of Pharmaceutics. 2015; 496(2):314-22.

  • Senthilkumar K, Vijaya C. Formulation Development of Mouth Dissolving Film of Etoricoxib for Pain Management. Advances in Pharmaceutics. 2015; 2015.

  • Gondkar SB, Namrata D P, Saudagar RB. Fast Dissolving Oral Films. Asian Journal of Pharmaceutical Research. 2016; 6(1): 56-58

  • Reddy SM, Shruthi B, Mounika B, Sowmya G. Fast Dissolving Drug Delivery System - A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2013; 6(1):4-11.

  • Madhavi BR, Devi NKD, Rani AP. Preparation and characterization of Zafirlukast-β-Cyclodextrin complexes using solid dispersion techniques. International Journal of Pharmaceutical Sciences. 2010; 4:88-93.

  • Ghorwade V, Patil A, Patil S, Srikonda K, Kotagiri R, Patel P. Development and evaluation of fast-dissolving film of montelukast sodium. World Journal of Medical Pharmaceutical and Biological Sciences. 2011; 1(1).

  • Dekhuijzen PR, Koopmans PP. Pharmacokinetic profile of zafirlukast. Clinical Pharmacokinetics. 2002; 41(2):105-14.

  • Fischer JD, Song MH, Suttle AB, Heizer WD, Burns CB, Vargo DL, et al. Comparison of Zafirlukast (Accolate®) Absorption After Oral and Colonic Administration in Humans. Pharmaceutical Research. 2000; 17(2):154-9.

  • Dasari N, Swapna, Sudhakar M. Design and evaluation of fast dissolving oral films of Zolpidem by solvent casting method. Asian Journal of Pharmaceutical Research. 2016; 6(2): 67-71.

  • 7. Singh TP, Singh RK, Shah JN, Mehta TA. Mucoadhesive bilayer buccal patches of Verapamil hydrochloride: Formulation development and characterization. International Journal of Pharmaceutical Sciences. 2014; 6(4):234-41.

  • 8. Sumedha B, Gopal G. Design and Optimization of Fast Dissolving Film of Losartan. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014; 7(11): 1211-1218.

  • Sabar MH. Formulation and in vitro evaluation of fast dissolving film containing amlodipine besylate solid dispersion. International Journal of Pharmacy and Pharmaceutical Sciences. 2013; 5(4):419-28.

  • Rahul S, Bushetti S, Shubhangi W, Bhagwat S, Nagar P, Shirur T. Development and evaluation of rizatriptan patches for buccal. World Journal of Pharmacy and Pharmaceutical Sciences. 2013; 2(6):5020-45.

  • Kumar SK, Nagabhushanam M, Sambasiva Rao K, Bhikshapathi D. Formulation development and in vivo evaluation of zolmitriptan oral dissolving films. International Journal of Pharma and Bio Sciences. 2013; 4(3):638-54.

  • Goudanavar PS, Bagali RS, Patil SM. Characterization and Evaluation of Glibenclamide Transmucosal Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology. 2010; 2(1):44-46.

  • Pharmacopoeia B. British pharmacopoeia. 2016.

  • Bala R, Sharma S. Formulation optimization and evaluation of fast dissolving film of aprepitant by using design of experiment. Bulletin of Faculty of Pharmacy, Cairo University. 2018.

  • Bhagat BV, Darkunde SL. Orodispersible Film: A Novel Drug Delivery System. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014. 7(10); 1196-1200.

  • Raja Y, Deborah D, Ambedkar T, Manohar Babu S. Formulation and Evaluation of Fast Dissolving Oral Films of Perindopril. Research Journal of Pharmaceutical Dosage Forms and Technology. 2014; 6(2):71-80

  • Sagban TH, Ismail KY. Formulation and evaluation of orodispersible film of sildenafil citrate. International Journal of Pharmacy and Pharmaceutical Sciences. 2014; 6(2):81-6.

  • Abdelbary A, Bendas ER, Ramadan AA, Mostafa DA. Pharmaceutical and pharmacokinetic evaluation of a novel fast dissolving film formulation of flupentixol dihydrochloride. AAPS PharmSciTech. 2014; 15(6):1603-10.

  • Deepthi A, Reddy BV, Navaneetha K. Formulation and evaluation of fast dissolving oral films of zolmitriptan. American Journal of Advanced Drug Delivery. 2014; 2(2):153-63.

  • Sushma M, Prasanna Raju Y, Sundaresan C, Vandana K, Vijay Kumar N, Harini Chowdary V. Transmucosal delivery of metformin-a comprehensive study. Current Drug Delivery. 2014; 11(2):172-8.

  • Suresh AM. Formulation and Evaluation of mucoadhesive buccal patches of Terbutaline Sulphate. Research Journal of Pharmaceutical Dosage Forms and Technology. 2016; 8(4): 248-254.

  • Bhyan B, Jangra S, Kaur M, Singh H. Orally fast dissolving films: innovations in formulation and technology. International Journal of Pharmaceutical Sciences Review and Research. 2011; 9(2):9-15.

  • Irfan M, Rabel S, Bukhtar Q, Qadir MI, Jabeen F, Khan A. Orally disintegrating films: a modern expansion in drug delivery system. Saudi Pharmaceutical Journal. 2016; 24(5):537-46.

  • Vidyadhara S, Balakrishna T, Sasidhar R, Babu C, Harika D. Formulation and evaluation of zolmitriptan fast dissolving buccal films. Scholars Research Library. 2013; 5:145-52.

  • Raju S, Reddy PS, Kumar VA, Deepthi A, Reddy KS, Reddy PM. Flash release oral films of metoclopramide hydrochloride for pediatric use: formulation and in-vitro evaluation. Journal of Chemical and Pharmaceutical Research. 2011; 3(4):636-46.

  • Chen T, Embree HD, Brown EM, Taylor MM, Payne GF. Enzyme-catalyzed gel formation of gelatin and chitosan: potential for in situ applications. Biomaterials. 2003; 24(17):2831-41.

  • Pandey GS, Kumar R, Sharma R, Singh Y, Teotia U. Effects of Maltodextrin and glycerin on mechanical properties of oral fast dissolving film of salbutamol sulphate. International Journal of advances in Pharmacy, Biology and Chemistry. 2014; 3(1):199-209.

  • Srikanth1, Anand KY, Mallikarjuna SC. Formulation and Evaluation of Maltodextrin Based Doxorubicin HCl Proniosomes. Research Journal of Pharmaceutical Dosage Forms and Technology. 2019. 12(6); 2776-2780.

  • Alam MT, Parvez N, Sharma PK. FDA-Approved natural polymers for fast dissolving tablets. Journal of Pharmaceutics. 2014; 2014.

  • Deshmane SV, Chinchole PP, Gaurkhede RM, Channawar MA, Chandewar AV. The Biopharmaceutics Classification System: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2009. 2(1); 8-11.

  • Waliszewski KN, Aparicio MA, Bello LsA, Monroy JA. Changes of banana starch by chemical and physical modification. Carbohydrate Polymers. 2003; 52(3):237-42.


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  • Effect of Natural/ Synthetic Polymers and Super Disintegrants on the Formulation of Zafirlukast Fast Dissolving Film

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Authors

Ashti M. H. Saeed
Department of Pharmaceutics, College of Pharmacy, Mustansiriyah University, Baghdad,, Iraq
Maryam Alaayedi
Department of Pharmaceutics, College of Pharmacy, University of Kerbala, Kerbala, Iraq., Iraq
Hayder Yahya Mansoor Al-Jarsha
Department of Pharmaceutics, College of Pharmacy, University of Baghdad, Baghdad,, Iraq

Abstract


Fast-dissolving films are one of the interested delivery systems for oral solid dosage forms to overcome swallowing difficulty for geriatric and pediatric patients. Zafirlukast (ZLK) is one of the most commonly used oral medication for treatment of asthmatic patients particularly mild to moderate cases. Oral fast dissolving films of ZLK were prepared using two different filming forming polymers, hydroxypropyl methylcellulose (HPMC) and sodium carboxymethyl cellulose (SCMC). Different concentrations of the 2 polymers were used to prepare 10 formulas. Other excipients were also added at various ratios to produce 10 different formulations. These were maltodextrin, crosspivodone, polyvinylpyrrolidone (PVP), and banana powder. In vitro characterization of the formulations showed that HPMC-based formulations had significantly shorter disintegrating times (p < 0.05) and improved dissolution rates. Addition of crosspovidone, PVP, and maltodextrin as disintegrants to the film forming polymers did not significantly enhance the disintegration of the films. However, banana powder significantly elongated the film disintegration. Compatibility studies using FTIR did not show an interaction between ZLK and excipients in all formulations.

Keywords


Oral Solid Dosage Form, Formulation, Fast-Dissolving Film, Zafirlukast, Filming Forming Polymer.

References