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Effect of Antenatal Betamethasone on Respiratory Distress Syndrome in Preterm Neonates


Affiliations
1 Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala,, India
2 Department of Pharmacy Practice, Nehru College of Pharmacy, P. K. Das Institute of Medical Science, Palakkad, Kerala,, India
     

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Respiratory Distress Syndrome (RDS) is one of the most common complications that cause the death among pre-term neonates (PNs). Use of Antenatal betamethasone is the effective intervention for the prevention of RDS and reducing early neonatal mortality and morbidity. Although there is limited information as to how effective this practice in developing countries. Aim of this study is to evaluate the effectiveness of betamethasone on RDS in PNs. We conducted a prospective, observational multi-centered study at Gynecology and Obstetrics, Neonatal department of two teaching hospitals in South India over a period of 6 months. All babies born alive before 37 weeks of gestation were included in the study. The study population included 70 PNs and they were classified into three based on the consumption of betamethasone (no dose, single dose and double dose). Among them, 28(40%) belonged to no dose, 25(35.7%) in single dose and 17(24.2) in double dose. Neonates whose mothers received two doses of betamethasone had a significantly lower incidence of RDS (P=0.043) than neonates whose mothers received a single dose of betamethasone (P=0.343). We concluded that a single complete course of betamethasone (Two doses of betamethasone 12mg 24 hours apart) is efficacious than one dose of betamethasone in prevention of RDS.

Keywords

Respiratory Distress Syndrome (RDS), Preterm Neonates (PNs), Betamethasone, Antenatal corticosteroids (ANC), Preterm complications.
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  • Sedigheh I et al. Effect of nursing support on perceived stress among parents and preterm infants in South-East of Iran. Asian J. Nur. Edu. & Research. 2014; 4(1): 81-86

  • Lotita SM et al. Prevention of nosocomial infection in NICU. Asian J. Edu. & Research. 2014;4(2):255-257.

  • Babitha O et al. Effectiveness of oral stimulation on improving sucking reflex among pre-term infants. Asian J. Edu.& Research. 2021; 11(1):25-27. DOI: 10.5958/2349-2996.2021.00007.0

  • Rajalakshmi S et al. A study to assess the level of stress and coping strategies among mothers of preterm infants admitted in neonatal intensive care unit at selected hospital, Puduchery. Int. J. Adv. Nur. Mangement. 2017; 5(1):45-50. DOI: 10.5958/2454-2652.2017.00010.5.

  • Omprakash B et al. Incidence of thrombocytopenia in hyperbilirubinemic neonates following phototherapy. Asian J. Research Chem. 2016; 4(1): 221-230. DOI: 10.5958/0974-4150.2015.00039.5

  • World Health Organization. Preterm 2021 [Internet]. Available from: https://www.who.int/news-room/fact-sheets/details/preterm-birth [Accessed 5 January 2021].

  • Davidoff MJ et al. Changes in the gestational age distribution among U.S. Singleton births: impact on rates of late pretermbirth,1992-2002.SeminPerinatol.2006;30(1): 8-15.DOI: 10.1053/j.semperi.2006.01.009.

  • Tejashree N. Hagawane et al. Oleic acid induced acute lung injury/ acute respiratory distress syndrome animal model. Research J. Pharm. and Tech. 2014; 7(8): 882-888

  • Dexamethasone versus betamethasone as an antenatal corticosteroid. UN commission/ Born Too Soon Care Antenatal corticosteroid working group [Internet] available from: (https://www.healthynewbornnetwork.org/hnn-content/uploads/ACS-Beta-vs-Dexa-130820.pdf) accessed on January 20

  • Respiratory Distress Syndrome. Available from: (https://www.stlouischildrens.org/condition-treatment/hyaline-membrane-disease-hmd-respiratory-distress-syndrome) accessed on 5th January 2021.

  • Darcy AE. Complications of the late preterm infant. J Perinat Neonatal Nurs. 2009; 23(1): 78-86.DOI: https://doi.org/10.1097/jpn.0b013e31819685b6

  • V. Indra. Effectiveness of Self-Instructional Module regarding New-Borns Respiratory Distress Syndrome in Thrissur, Kerala. Int. J. Nur. Edu. and Research. 2017; 5(4): 431-435. doi: 10.5958/2454-2660.2017.00092.8

  • Chhatrala JJ and Chawada R. Comparative study of dexamethasone and betamethasone for women at risk of preterm birth. Int. J Reprod Contracept Obstet Gynecol. 2015; 4(4): 1000-1003.DOI: http://dx.doi.org/10.18203/2320-1770.

  • Pattanittum P et al. Use of antenatal corticosteroids prior to preterm birth in four South East Asian countries with in THE SEA-ORCHID project. BMC Pregnancy and Childbirth.2008;8:4

  • Shapiro-Mendoza CK and Lackritz EM. Epidemiology of late and modern preterm birth. Semin Fetal Neonatal Med. 2009; 10(3): 287-294. DOI: 10.1016/j.siny.2012.01.007

  • Serrano IMG et al. Antenatal Corticosteroid Therapy and Late Preterm Infant Morbidity and Mortality. AnPediatr (Barc). 2014; 81(6): 374-382.DOI: 10.1016/j.anpedi.2014.01.026.

  • Leone A et al. Neonatal morbidity in singleton late preterm infants compared with full-term infants. Acta Paediatr. 2012; 101(1): 6-10.DOI: 10.1111/j.1651-2227.2011.02459.

  • Darcy AE. Complications of the late preterm infant. J Perinat Neonatal Nurs. 2009; 23(1): 78-86. DOI: 10.1097/JPN.0b013e31819685b6.

  • Escobar GJ et al. Short-term outcomes of infants born at 35- and 36-weeks’ gestation: we need to ask more questions. Semin Perinatol. 2006; 30(1): 28-33. DOI: 10.1053/j.semperi.2006.01.005

  • Operational guidelines for use of Antenatal Corticosteroids in preterm labour – By Child Health Division, Ministry of health and family welfare, GOI. Available from: (http://www.nrhmorissa.gov.in/writereaddata/Upload/Documents/Operational%20Guidelines-Use%20of%20Antenatal%20Corticosteroids%20in%20Preterm%20Labour.pdf) accessed on 20 February 2021.

  • ACOG Committee Opinion, No.475: antenatal corticosteroid therapy for fetal maturation. Obstet Gynecol.2011;117(2):422-424. DOI:10.1097/aog.0b013e31820eee00 22. Crowley P. Prophylactic corticosteroids for preterm birth. Cochrane Database Syst. Rev.2000;2:CD 000065. https://doi.org/10.1002/14651858.cd000065

  • Jagadeesh GH. A descriptive study to assess the knowledge regarding management of birth asphyxia among the staff nurses working in labour room and NICU. Asian J. Edu.& Research. 2015; 5(1): 80-86. DOI: 10.5958/2349-2996.2015.00018.X.

  • Sasikala T et al. Therapeutic effects of music therapy on preterm neonates- pilot study report. Int. J. Nur. Edu. and Research. 2016; 4(1): 42-44. DOI: 10.5958/2454-2660.2016.00007.7

  • Lavanya S et al. Maternal empowerment programme for mothers of preterm infants. Int. J. of Advances in Nur. Management. 2021; 9(1): 106-109. DOI: 10.5958/2454-2652.2021.00028.7.

  • Vidaeff AC et al. Antenatal corticosteroids for fetal maturation in women at risk for preterm delivery. Clin Perinatol. 2003; 30(4): 825-840. https://doi.org/10.1016/s0095-5108(03)00102-7

  • Gyamfi-Bannerman C et al. Effect of antenatal corticosteroids on respiratory morbidity in singletons after late- preterm birth. Obstet Gynecol. 2012; 119(3): 555-559. https://dx.doi.org/10.1097%2FAOG.0b013e31824758f6

  • Eriksson L et al. Health consequences of prophylactic exposure to antenatal corticosteroids among children born late preterm or term. Acta Obstet Gynecol Scand. 2012; 91: 1415-1421. DOI: 10.1111/aogs.12014


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  • Effect of Antenatal Betamethasone on Respiratory Distress Syndrome in Preterm Neonates

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Authors

Haripriya P. S.
Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala,, India
Dhanya Mary Louis
Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala,, India
Nikita Naushad
Department of Pharmacy Practice, Nehru College of Pharmacy, P. K. Das Institute of Medical Science, Palakkad, Kerala,, India
Merin Tomy
Department of Pharmacy Practice, Nehru College of Pharmacy, P. K. Das Institute of Medical Science, Palakkad, Kerala,, India
Sreelakshmi M.S.
Department of Pharmacy Practice, Nehru College of Pharmacy, P. K. Das Institute of Medical Science, Palakkad, Kerala,, India
Narmadha M.P.
Department of Pharmacy Practice, Amrita School of Pharmacy, Amrita Institute of Medical Sciences, AIMS Ponekkara PO, Kochi, Kerala,, India

Abstract


Respiratory Distress Syndrome (RDS) is one of the most common complications that cause the death among pre-term neonates (PNs). Use of Antenatal betamethasone is the effective intervention for the prevention of RDS and reducing early neonatal mortality and morbidity. Although there is limited information as to how effective this practice in developing countries. Aim of this study is to evaluate the effectiveness of betamethasone on RDS in PNs. We conducted a prospective, observational multi-centered study at Gynecology and Obstetrics, Neonatal department of two teaching hospitals in South India over a period of 6 months. All babies born alive before 37 weeks of gestation were included in the study. The study population included 70 PNs and they were classified into three based on the consumption of betamethasone (no dose, single dose and double dose). Among them, 28(40%) belonged to no dose, 25(35.7%) in single dose and 17(24.2) in double dose. Neonates whose mothers received two doses of betamethasone had a significantly lower incidence of RDS (P=0.043) than neonates whose mothers received a single dose of betamethasone (P=0.343). We concluded that a single complete course of betamethasone (Two doses of betamethasone 12mg 24 hours apart) is efficacious than one dose of betamethasone in prevention of RDS.

Keywords


Respiratory Distress Syndrome (RDS), Preterm Neonates (PNs), Betamethasone, Antenatal corticosteroids (ANC), Preterm complications.

References