Journal of Pierre Fauchard Academy (India Section)

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Management of Oral Leukoplakia – Non-Surgical and Surgical Treatment .


Affiliations
1 Professor and HOD, Department of Oral Medicine and Radiology, Government Dental College and Hospital, Ahmedabad – 380016, Gujarat, India ., India
2 Post Graduate Student, Department of Oral Medicine and Radiology, Government Dental College and Hospital, Ahmedabad – 380016, Gujarat, India ., India
     

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Aim: To evaluate the efficacy of topical retinoic acid (A-RET gel-0.025%) in homogenous leukoplakia and diode laser in non-homogenous leukoplakia patients (speckled, nodular and verrucous). Study Design: Study included total 30 patients of clinically diagnosed cases of leukoplakia; homogenous leukoplakia (n = 15) and non-homogenous leukoplakia (n = 15). Material and Method: Homogenous leukoplakia patients were given treatment of topical A-RET gel and antioxidant, while non homogenous leukoplakia patients were surgically treated by diode laser. Patients were followed up for healing after diode laser. Results: Total regression was reported in almost all cases of homogenous leukoplakia within one month, without any recurrence. Speckled leukoplakia and buccal mucosa showed faster healing as compared to other types of nonhomogenous leukoplakia with laser. Conclusion: A-RET gel and diode laser gives excellent results in homogenous and non homogenous leukoplakia cases respectively. Type of leukoplakia and lesion site plays an important role in prognosis of the lesion.

Keywords

Antioxidant, Diode Laser, Oral Leukoplakia, Tretinoin .
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  • Parlatescu I, Gheorghe C, Coculescu E, Tovaru S. Oral leukoplakia - An update. Maedica. 2014 Mar; 9(1):88–93.

  • Natekar M, Raghuveer HP, Rayapati DK, Shobha ES, Prashanth NT, Rangan V, Panicker AG. A comparative evaluation: Oral leukoplakia surgical management using diode laser, CO2 laser,and cryosurgery. Journal of Clinical and Experimental Dentistry. 2017 Jun; 9(6):e779. PMid: 28638555 PMCid: PMC5474334. https://doi.org/10.4317/ jced.53602

  • Deliverska EG, Petkova M. Management of oral leukoplakia - Analysis of the literature. Journal of IMAB-Annual Proceeding Scientific Papers. 2017 Mar 26; 23(1):1495– 504. https://doi.org/10.5272/jimab.2017231.1495

  • Femiano F, Gombos F, Scully C, Battista C, Belnome G, Esposito V. Oral leukoplakia: open trial of topical therapy with calcipotriol compared with tretinoin. International Journal of Oral and Maxillofacial Surgery. 2001 Oct 1; 30(5):402–6. PMid: 11720042. https://doi.org/10.1054/ ijom.2001.0107

  • Luke AM, Mathew S, Altawash MM, Madan BM. Lasers: A review with their applications in oral medicine. Journal of Lasers in Medical Sciences. 2019; 10(4): 234-329. PMid: 31875126 PMCid: PMC6885906. https://doi.org/10.15171/ jlms.2019.52

  • Yasmeen SA, Reddy BS, Ramesh MV, Birajdar SS, Yarram A, Kumar NN. A comparative evaluation of diode laser ablation versus scalpel excision for management of oral leukoplakia. Journal of Indian Academy of Oral Medicine and Radiology. 2019 Apr 1; 31(2):94-99. https://doi.org/10.4103/jiaomr.jiaomr_4_19

  • Ripley PM. The physics of diode lasers. Lasers in Medical Science. 1996 Jun; 11(2):71–8. https://doi.org/10.1007/ BF02133204

  • Ortega-Concepción D, Cano-Durán JA, Peña-Cardelles JF, Paredes-Rodríguez VM, González-Serrano J, López-Quiles J. The application of diode laser in the treatment of oral soft tissues lesions. A literature review. Journal of Clinical and Experimental Dentistry. 2017 Jul; 9(7):e925. PMid: 8828162 PMCid: PMC5549593. https://doi.org/10.4317/ jced.53795

  • Akbulut N, Kursun ES, Tumer MK, Kamburoglu K, Gulsen U. Is the 810-nm diode laser the best choice in oral soft tissue therapy? European Journal of Dentistry. 2013 Apr; 7(02):207–11. PMid: 24883028 PMCid: PMC4023194.https://doi.org/10.4103/1305-7456.110174

  • Arora KS, Bansal R, Mohapatra S, Verma A, Sharma S, Pareek S. Prevention of malignant transformation of oral leukoplakia and oral lichen planus using laser: An observational study. Asian Pacific Journal of Cancer Prevention: APJCP. 2018; 19(12):3635- 3641. PMid: 30583693 PMCid: PMC6428544. https://doi.org/10.31557/ APJCP.2018.19.12.3635

  • Kundoor VK, Patimeedi A, Roohi S, Maloth KN, Kesidi S, Masabattula GK. Efficacy of diode laser for the management of potentially malignant disorders. Journalof Lasers in Medical Sciences. 2015; 6(3):120-123. PMid: 26464779 PMCid: PMC4599198. https://doi.org/10.15171/ jlms.2015.05

  • Kharadi UA, Onkar S, Birangane R, Chaudhari S, Kulkarni A, Chaudhari R. Treatment of oral leukoplakia with diode laser: A pilot study on Indian subjects. Asian Pacific Journal of Cancer Prevention. 2016; 16(18):8383-8386. PMid: 26745089. https://doi.org/10.7314/APJCP.2015.16.18.8383

  • Warnakulasuriya S. Clinical features and presentation of oral potentially malignant disorders. Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 2018 Jun 1; 125(6):582–90. PMid: 29673799. https://doi.org/10.1016/j.oooo.2018.03.011

  • Syed TF, Thukral N. CO2 laser surgery for the excision of leukoplakia: A comparison with the traditional technique.J Oral Laser Applications. 2009; 9(4):213–8.

  • Krishnamurthy V, Pagare SS, et al. A clinical study ablation of oral leukoplakia with CO2 laser. Scientific Journal.2009; 3.

  • Tanaka T, Ishigamori R. Understanding carcinogenesis for fighting oral cancer. Journal of Oncology. 2011 May 12; Article ID 603740. PMid: 21772845 PMCid: PMC3136173. https://doi.org/10.1155/2011/603740

  • Schoelch ML, Sekandari N, Regezi JA, Silverman Jr S. Laser management of oral leukoplakias: A follow-up study of 70 patients. The Laryngoscope. 1999 Jun; 109(6):949–53. PMid: 10369289. https://doi.org/10.1097/00005537-19990600000021

  • Abidullah M, Kiran G, Gaddikeri K, Raghoji S. Leuloplakia - Review of a potentially malignant disorder. Journal of Clinical and Diagnostic Research: JCDR. 2014 Aug; 8(8):ZE01–ZE04.

  • Ishii J, Fujita K, Munemoto S, Komori T. Management of oral leukoplakia by laser surgery: Relation between recurrence and malignant transformation and clinicopathological features. Journal of Clinical Laser Medicine and Surgery.2004 Feb 1; 22(1):27–33. PMid: 15117484. https://doi. org/10.1089/104454704773660949

  • Sankaranarayanan R, Mathew B, Varghese C, Sudhakaran PR, Menon V, Jayadeep A, Nair MK, Mathews C, Mahalingam TR, Balaram P, Nair PP. Chemoprevention of oral leukoplakia with vitamin A and beta carotene: An assessment. Oral Oncology. 1997 Jul 1; 33(4):231–6.https://doi.org/10.1016/S0964-1955(97)00010-9

  • Mondal K, Mandal R, Sarkar BC, Das V. An inter-correlative study on clinico-pathological profile and different predisposing factors of oral leukoplakia among the ethnics of Darjeeling, India. Journal of Orofacial Sciences. 2017 Jan 1; 9(1):34–42. https://doi.org/10.4103/0975-8844.207942

  • Chandra P, Govindraju P. Prevalence of oral mucosal lesions among tobacco users. Oral Health and Preventive Dentistry. 2012 Jan 1; 10(2):149–153.

  • Silverman Jr S, Bhargava K, Mani NJ, Smith LW, Malaowalla AM. Malignant transformation and natural history of oral leukoplakia in 57,518 industrial workers of Gujarat, India. Cancer. 1976 Oct; 38(4):1790–5. https:// doi.org/10.1002/1097-0142(197610)38:4<1790::AIDCNCR2820380456>3.0.CO;2-I

  • Mishra M, Mohanty J, Sengupta S, Tripathy S.Epidemiological and clinicopathological study of oral leukoplakia. Indian Journal of Dermatology, Venereology and Leprology. 2005 May 1; 71(3):161–165. PMid: 16394403. https://doi.org/10.4103/0378-6323.16229

  • Epstein JB, Gorsky M. Topical application of vitamin A to oral leukoplakia: A clinical case series. Cancer: Interdisciplinary International Journal of the American Cancer Society. 1999 Sep 15; 86(6):921–7. https://doi. org/10.1002/(SICI)1097-0142(19990915)86:6<921::AIDCNCR5>3.0.CO;2-6

  • Praveen KN, Veeraraghavan G, Reddy RS, Kotha P, KoneruJ, Yelisetty K. Management of oral leukoplakia using diode laser: A pilot study. Journal of Advances in Medicine and Medical Research. 2015 Aug 24:1–6. https://doi. org/10.9734/BJMMR/2015/19178

  • Raval N, Raju DR, Athota A, Reddy TY. Diode laser and white lesions: A clinical study on postoperative

  • recovery, depth control and wound healing. Journal of Indian Academy of Oral Medicine and Radiology.

  • Jul 1; 23(5):S308-S311. https://doi.org/10.5005/jp-journals-10011-1156

  • Bagan J, Murillo-Cortes J, Leopoldo-Rodado M, SanchisBielsa JM, Bagan L. Oral cancer on the gingiva in patients with proliferative leukoplakia: A study of 30 cases. Journal

  • of Periodontology. 2019 Oct; 90(10):1142–8. PMid: 31074011. https://doi.org/10.1002/JPER.18-0620

  • Tatu R, Shah K, Palan S, Brahmakshatriy H, Patel R. Laser excision of labial leukoplakia with diode laser: A casereport. IJRRMS. 2013 Oct; 3(4):64–6.

  • Roodenburg JL, Panders AK, Vermey A. Carbon dioxide laser surgery of oral leukoplakia. Oral Surgery, Oral Medicine, Oral Pathology. 1991 Jun 1; 71(6):670–4. https:// doi.org/10.1016/0030-4220(91)90271-D .


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  • Management of Oral Leukoplakia – Non-Surgical and Surgical Treatment .

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Authors

Jigna Sathya Shah
Professor and HOD, Department of Oral Medicine and Radiology, Government Dental College and Hospital, Ahmedabad – 380016, Gujarat, India ., India
Himali Alkeshbhai Shah
Post Graduate Student, Department of Oral Medicine and Radiology, Government Dental College and Hospital, Ahmedabad – 380016, Gujarat, India ., India

Abstract


Aim: To evaluate the efficacy of topical retinoic acid (A-RET gel-0.025%) in homogenous leukoplakia and diode laser in non-homogenous leukoplakia patients (speckled, nodular and verrucous). Study Design: Study included total 30 patients of clinically diagnosed cases of leukoplakia; homogenous leukoplakia (n = 15) and non-homogenous leukoplakia (n = 15). Material and Method: Homogenous leukoplakia patients were given treatment of topical A-RET gel and antioxidant, while non homogenous leukoplakia patients were surgically treated by diode laser. Patients were followed up for healing after diode laser. Results: Total regression was reported in almost all cases of homogenous leukoplakia within one month, without any recurrence. Speckled leukoplakia and buccal mucosa showed faster healing as compared to other types of nonhomogenous leukoplakia with laser. Conclusion: A-RET gel and diode laser gives excellent results in homogenous and non homogenous leukoplakia cases respectively. Type of leukoplakia and lesion site plays an important role in prognosis of the lesion.

Keywords


Antioxidant, Diode Laser, Oral Leukoplakia, Tretinoin .

References