Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

An Institutional Study for Determining the Correlation of Oral Submucous Fibrosis with Serum Haemoglobin Level:A Retrospective Analysis of 100 Cases


Affiliations
1 Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, India
     

   Subscribe/Renew Journal


Aim: Oral submucous fibrosis (OSF) is a potentially malignant, chronic progressive disorder affecting most parts of the oral cavity with different clinical presentation depending upon the stage of the disease. It has multifactorial aetiology triggering the disease process. Aetiological factors that have been attributed are areca nut chewing, nutritional deficiencies, immunological processes and genetic predisposition. Patients with OSF show significant decrease in the level of haemoglobin causing anaemia. The aim of this study was to find for any correlation between the serum haemoglobin level and OSF.
Materials and methods: In this institutional study, 100 clinically diagnosed and histopathologically confirmed OSF patients were retrieved, of which 68 patients were included in the study along with 30 healthy controls. Serum haemoglobin levels were retrieved retrospectively from the haematological records.
Results: The study showed no significant correlation between OSF and serum haemoglobin. Serum haemoglobin in the study group and the control group did not show any significant difference.
Conclusion: There is no significant correlation between the serum haemoglobin level with OSF and also with control groups. Further large-scale prospective studies with different stages of OSF are indicated to find a correlation between the level of serum haemoglobin and OSF in this part of the country.

Keywords

Oral Submucous Fibrosis, Serum Haemoglobin, Iron Deficiency Anaemia.
User
Subscription Login to verify subscription
Notifications
Font Size

  • Warnakulasuriya S, Johnson NW, Van der Waal I. Nomenclature and classification of potentially malignant disorders of the oral mucosa. J Oral Pathol Med. 2007;36: 575–580.
  • Hegde K, Nair P, Gharote HP, Agarwal K, Bhat GR, Rajaram DK. Role of hemoglobin and serum iron in oral submucous fibrosis: a clinical study. Sci World J. 2012;2012:.
  • Rajendran R, Vijayakumar T, Vasudevan DM. An alternative pathogenetic pathway for oral submucous fibrosis (OSMF). Med Hypotheses. 1989;30:35–37.
  • Khanna S. Immunological and biochemical markers in oral carcinogenesis: the public health perspective. Int J Environ Res Public Health. 2008;5:418–422.
  • Kumar KK, Saraswathi TR, Ranganathan K, Uma Devi M, Joshua E. Oral submucous fibrosis: a clinicohistopathological study in Chennai. Indian J Dent Res. 2007;18:108–111.
  • Pandya S, Chaudhary AK, Singh M, Mehrotra R. Correlation of histopathologic diagnosis with habits and clinical findings in Oral Submucous Fibrosis. Head Neck Oncol. 2009;1:10.
  • Seedat HA, Van Wyk CW. Betel-nut chewing and submucous fibrosis in Durban. SAMJ. 1988;74:568–571.
  • Rajendran R. Oral submucous fibrosis: etiology, pathogenesis, and future research. Bull World Health Organ. 1994;72:985–996.
  • Clark SF. Iron deficiency anemia: diagnosis and management. Curr Opin Gastroenterol. 2009;25:122–128.
  • Rajendran R, Sivapathasundharam B. Shafer's Textbook of Oral Pathology. 6th ed. Elsevier India; 2009:86–100.
  • Kakar PK, Puri RK, Venkatachalam VP. Oral submucous fibrosis—treatment with hyalase. J Laryngol Otol. 1985;99: 57–59.

Abstract Views: 226

PDF Views: 0




  • An Institutional Study for Determining the Correlation of Oral Submucous Fibrosis with Serum Haemoglobin Level:A Retrospective Analysis of 100 Cases

Abstract Views: 226  |  PDF Views: 0

Authors

Irengbam Vidyalakshmi
Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, India
Chaitanya N. Babu
Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, India
K. Deepika
Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, India
G. M. Revanna
Department of Oral and Maxillofacial Pathology, The Oxford Dental College, Bangalore, Karnataka, India

Abstract


Aim: Oral submucous fibrosis (OSF) is a potentially malignant, chronic progressive disorder affecting most parts of the oral cavity with different clinical presentation depending upon the stage of the disease. It has multifactorial aetiology triggering the disease process. Aetiological factors that have been attributed are areca nut chewing, nutritional deficiencies, immunological processes and genetic predisposition. Patients with OSF show significant decrease in the level of haemoglobin causing anaemia. The aim of this study was to find for any correlation between the serum haemoglobin level and OSF.
Materials and methods: In this institutional study, 100 clinically diagnosed and histopathologically confirmed OSF patients were retrieved, of which 68 patients were included in the study along with 30 healthy controls. Serum haemoglobin levels were retrieved retrospectively from the haematological records.
Results: The study showed no significant correlation between OSF and serum haemoglobin. Serum haemoglobin in the study group and the control group did not show any significant difference.
Conclusion: There is no significant correlation between the serum haemoglobin level with OSF and also with control groups. Further large-scale prospective studies with different stages of OSF are indicated to find a correlation between the level of serum haemoglobin and OSF in this part of the country.

Keywords


Oral Submucous Fibrosis, Serum Haemoglobin, Iron Deficiency Anaemia.

References