Journal of Natural Remedies

G. S. Chakraborthy ¹, Pinkal Patel ¹, Sachin Sharma ¹, Rupal K. Jani ¹, Snigdha Das Mandal ¹

Affiliations
1 Faculty of Pharmacy, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat, IN

Abstract

Herbs have been used to treat various diseases in one form or another for the betterment of mankind since the ancient ages. As a result of this usage, the situation gradually deteriorated due to overexploitation, resulting in a decrease in natural resource production. Looking in to the benefits, the flora and fauna were rehabilitees through tissue culture, conservation, plantation and other means to ensure their availability in their natural form. Nature is the best chemist, as it aids in the treatment of ailments and provides the results of them. It is impossible to find any plant that has no medical use. Ulcer and liver diseases are at an alarming rate in the developing countries. A number of drugs, which are in the existing medications for peptic ulcer and hepatic diseases, are on the comeback list due to their adverse effects and drug interactions. Drugs, which are derived from the flora, have an important role in treatment and show a higher rate of acceptance. Flavonoids are the naturally occurring, low-molecular-weight molecules seen mostly distributed in the vegetable kingdom and hold an utmost thurst in declining the generation of reactive oxygen species. Secondary compounds like apigenin, sylimarin, genesis, quercetin, kaempherol and catechins have a significant role in these diseases. This article focuses on the importance of flavonoids, which can serve as potent anti-ulcer and hepatoprotective agents.

Keywords

Flavonoids, Herbs, Liver, Secondary Metabolites, Ulcer.

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Mittal Dalal ¹, Hardik Soni ², Devanshu J. Patel ³, Snigdha Das Mandal ⁴, Jainee Daxesh Vashi ⁴

Affiliations
1 Department of Pharmacology, L.M. College of Pharmacy, Ahmedabad - 380009, Gujarat, IN
2 Vasu Research Center (A Division of Vasu Healthcare Pvt. Ltd.), G.I.D.C., Makarpura, Vadodara - 390010, IN
3 Department of Pharmacology, Parul Institute of Medical Science and Research, Parul University, Limda, Waghodia, Vadodara - 391760, Gujarat, IN
4 Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara, Gujarat - 391760, IN

Abstract

Benign prostatic hyperplasia (BPH) is an enlargement of the prostate gland caused by progressive hyperplasia, or abnormal growth of cells of the glandular epithelial and stromal cells. Globally, it has been documented that more than 80% of men by the age of 80 will suffer from BPH. Most men are hesitant to undergo surgical interventions for fear of losing potency and the perception of other adverse side effects. Effectto® is a polyherbal formulation designed by Vasu Research Center to be used for the treatment of BPH. It can also be indicated that it can be used for lower urinary tract symptoms and bladder outlet obstruction. The formulation is expected to provide significant BPH relief. The present study was planned to evaluate the effect of a polyherbal formulation on testosterone- and citral-induced Prostatic Hyperplasia. The activity of the polyherbal formulation for BPH was evaluated using testosterone depot injection as the inducing agent in a testosterone-induced model and citral-induced model for the atypical type of BPH in rats. Also, the acute toxicity study was done using OECD 423 guidelines to check the toxicity of the test compound. Data are expressed as mean ± SD and statistical significance was evaluated using one way ANOVA followed by Tukey’s multiple comparison tests. The polyherbal formulation was found to be safe at oral doses of 2000 mg/kg. Effectto® significantly decreased the weight of the prostate in the testosterone model as well as the citral model in rats. The effect on biochemical markers like serum PSA and TNF-α was also seen in both the cases. In particular serum PSA, the decrease was majorly significant in both the models when XIII compared. The formulation was able to reverse the effect of inducing agents on the prostate’s size.

Keywords

Benign Prostatic Hyperplasia, Citral, Effectto®, Finasteride, LUTS, PSA, Testosterone.

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Gunosindhu Chakraborthy ¹, Snigdha Das Mandal ¹, Rupal K. Jani ¹

Affiliations
1 Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391760, Gujarat, IN

Abstract

Holoptelea integrifolia (Ulmaceae) is a diversely used in Traditional Systems of medicine for healing aliments. The plant is preferred in the treatment and curing diseases like leprosy, inflammation, rickets, leucoderma, scabies, rheumatism, eczema, malaria and many more. The plants exhibits various pharmacological activities like antimicrobial, nociceptive, antiaging ,inflammation, anthelmintic, antidiabetic, adaptogenic, anticancer, wound healing, hepatoprotective, and hypolipidemic. The study on moprphological and microscopical was carried out on this plant as per the standards laid down by who to find the genuinity of the species. Physical constant values involving moisture content, ash and extractives as well as qualitative and quantitative estimation of various phytochemical have been studied. The presence of Saponins, Tannins, Terpenoids, Steroid, Flavonoids, and some other chemical constituents were recorded followed by antimicrobial activity of the plant against Gram Positive and Gram Negative Bacteria. Looking forward with the potential aspects of the plant used in Traditional system standardization parameters were to be considered for its validation and authentication.

Keywords

Antimicrobial, Ethnobotany, Phytoconstituents, Standardization.

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Prachi Vishwakarma ¹, Shailesh V. Deshpande ¹, Snigdha Das Mandal ²

Affiliations
1 Department of Kayachikitsa, Parul Institute of Ayurveda, Parul University, Vadodara - 391760, Gujarat, IN
2 Department of Pharmacology, Parul Institute of Pharmacy and Research, Parul University, Vadodara - 391760, Gujarat, IN

Abstract

The assumption that medicinal plants are less toxic or cause fewer adverse effects due to their natural composition is debatable. Hence, this study was conducted to evaluate the safety and toxicity of Nano Kanchanara stem bark powder (NKSP) on liver function. The oral acute toxicity of NKSP was conducted in accordance with OECD Guidelines 423 and was carried out with six (6) female Wistar albino rats, divided into two groups of three rats each. Test rats were orally administered a single dose of 2000 mg/kg of NKSP and were observed for changes in behavior and mortality for the next 14 days, while the Control Group was given feed and water ad libitum. The data obtained from the oral acute toxicity study indicated that there were non-significant (P<1.000) decreases in body weight of rats in the treatment groups of NKSP at 2000 mg/kg. There were no elevations in specific liver function enzymes, whereas there were increases in serum SGOT, SGPT, and albumin levels. Plasma total proteins and globulin, total bilirubin and serum creatinine were within the normal range. Albeit, hydropic changes and steatosis in liver lesions at NKSP 2000 mg/kg. The study suggests that oral administration of NKSP is safer at dose levels less than 2000 mg/kg/day.

Keywords

Bauhinia variegata Linn., Liver Toxicity, Medicinal Plant, Safety.

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