Journal of Natural Remedies

S. S. Sadekar , V. B. Chauhan , R. L. Shirole , B. U. Salve , V. S. Kasture , S. B. Kasture

Abstract

Objective: The objective of this study was to investigate the effect of acetone soluble fraction of methanolic extract of leaves of Vitex negundo on dopaminergic function. Methods: The effect of acetone soluble fraction of methanolic extract of leaves of Vitex negundo (50 and 100 mg/kg, i.p.) was studied on haloperidol-induced catalepsy in mice, amphetamine-induced stereotyped behavior in rats and dopamineinduced contraction of isolated vas deferens preparation of rat. Results: The acetone soluble fraction of methanolic extract of V. negundo significantly potentiated haloperidol-induced catalepsy, antagonized dose dependent amphetamine- induced stereotyped behavior, and also antagonized dopamine-induced contractions of rat vas deferens. Conclusion: The results suggest that the methanolic extract of Vitex negundo possessed antidopaminergic principles.

Keywords

Antidopaminergic, Vitex negundo, Amphetamine, Haloperidol

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