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Objective: To investigate the hypoglycemic activity of ethanolic extract of leaves of sweet and bitter varieties of Aegle marmelos in normal rabbits. Methods: Albino rabbits were treated with ethanolic extract of leaves of two varieties (sweet and bitter) of Aegle marmelos (250 mg/kg and 500 mg/kg, p.o and tolbutamide (40 mg/kg, p.o). Blood samples were collected from marginal ear vein just before and 0.5, 1, 2, 4, 6, 8, 16 and 24 h after the commencement of the experiment. Glucose-Oxidase assay method was used for the estimation of blood glucose. Results: Sweet and bitter varieties of Aegle marmelos produced hypoglycemic activity in a dose dependent manner. Sweet variety (250 mg/kg, 500 mg/kg) produced maximum percent blood glucose reduction (10.59±0.26, 15.9±0.55) at 6 h. Bitter variety (250 mg/kg, 500 mg/kg) produced maximum percent blood glucose reduction (21.96±0.43, 41.68±1.26) at 8 h and continued upto 24 h. Tolbutamide (40 mg/kg) produced maximum percent blood glucose reduction (38.90±0.71) at 6 h. Conclusion: Bitter variety of Aegle marmelos produced greater hypoglycemia than the sweet variety and the difference may be due to the presence of potent bioactive molecules in bitter variety.

Keywords

Aegle marmelos, Bitter, Sweet, Hypoglyemic Activity

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