Journal of Natural Remedies

Janki B. Patel ¹, Mansi Gajera ¹, Zalak Shah ¹, Pinkal Patel ¹, Kinjal Parmar ¹, Vaishali Patel ¹, Hetvi Patel ¹, Disha Patel ¹, Kanupriya Rathore ¹

Affiliations
1 Faculty of Pharmacy, Department of Pharmaceutics, Parul Institute of Pharmacy and Research, Parul University, Vadodara – 391760, Gujarat, IN

Abstract

The goals of the current studies were to create herbal excipients-based ketoconazole cream to enhance the efficacy against chronic mucocutaneous candidiasis. Ketoconazole, coconut oil and other herbal excipients namely shea butter, bees wax, Lanolin and Rose oil were used for the formulation. Each formulation was prepared with various concentrations of coconut oil. Every prepared formulations were evaluated successfully. Among all the formulations F4 was the best that exhibiting a higher in vitro diffusion rate 59.6 ± 0.10 % CDR within 480 min with maximum antifungal efficacy, compared with the marketed formulation. We might therefore say that herbal excipients-based cream improved patient compliance and is a superior alternative to oral preparation, easier administration, local bioavailability, and better results for individuals with persistent mucocutaneous candidiasis who are afflicted with fungi.

Keywords

Anti-Fungal Activity, Cream Formulation, Coconut Oil, Herbal Excipients, Ketoconazole, Shea Butter

Full Text