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Velraj, Malarkodi
- Antiinflammatory Activity of Adenanthera pavonina Linn. Leaves
Authors
Source
Journal of Natural Remedies, Vol 12, No 1 (2012), Pagination: 56-62Abstract
Antiinflammatory activity of Adenanthera pavonina Linn. leaves were evaluated using formalin induced rat paw oedema model for acute inflammation and cotton pellet granuloma model for chronic inflammation. The leaves of the plant was extracted with methanol by cold maceration method. The methanolic extract was fractionated with water. The extract and its aqueous fraction were screened for its anti inflammatory activity at the dose levels of 200mg/kg and 400mg/kg. Compared with control both showed significant activity against acute and chronic inflammation. Aqueous fraction of methanolic extract significantly inhibit the paw oedema in acute model and granuloma formation in chronic model with respect to the methanolic extract. The results indicates that the antiinfammatory activity of Adenanthera pavonina leaf extract could be through a inhibition of elevated prostaglandin biosynthesis and reduction of proliferative mass inflammed cells.The present results of anti inflammatory activity supports the folklore claim of Adenanthera pavonina leaves.Keywords
Adenanthera pavonina, Formalin,cotton Pellet Granuloma, Anti InflammatoryFull Text
- Phytochemical Analysis by HR-LCMS and In vitro Anti-diabetic Potential of Michelia champaca Bark
Authors
1 Department of Pharmacognosy, School of Pharmacy, GNITC, Hyderabad – 501506, Telangana Department of Pharmacognosy, VELS Institute of Science, Technology and Advanced studies, Chennai – 600117, Tamil Nadu, IN
2 Department of Pharmacognosy, VELS Institute of Science, Technology and Advanced studies, Chennai – 600117, Tamil Nadu, IN
Source
Journal of Natural Remedies, Vol 22, No 3 (2022), Pagination: 432 - 439Abstract
The current analysis was aimed to study the phytochemical profile and in vitro antidiabetic capacity of HEMC bark. HR-LCMS1 was used to identify the phytochemicals present in the extract. The outcomes of HR-LCMS showed the presence of 15 phytochemical compounds. DL-Carnitine, Catechin, D-α-Tocopherol, Colchicine, Myricetin, Epicatechin, Quercetin, Epigallocatechin gallate, Quercetin-3β-D-glucoside, Kaempferol, Sorbic acid, Apocynin, Epigallocatechin gallate, myricetin 3-O-beta-D-galactopyranoside, Naringeninchalcone are the main compounds identified. The inhibition of enzymes like α-amylase and α-glucosidase delays the rate of glucose absorption thus reducing blood glucose levels in the experimental models. The IC50 values of α-amylase and α-glucosidase inhibitory activity of HEMC were acquired to be 88.65 μg/mL and 71.28 μg/mL correspondingly. Positive control acarbose displayed IC50 assessment of 52.94 μg/mL and 50.01 μg/mL correspondingly. Consequently, the current study confirms that HEMC had remarkable antidiabetic activity and hence holds future potential as nutraceuticals in the treatment of diabetes and related ailments.
Keywords
HR – LCMS, Antidiabetic, Michelia champaca, Bark, α-amylase, α-glucosidase.Full Text
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