Journal of Natural Remedies

S. D. Joshi , V. D. Kulkarni , V. H. Kulkarni , H. M. Vagdevi , V. P. Vaidya , V. P. Veerapur , A. M. Badiger

Abstract

Objective: The present study is aimed to evaluate the leaf extracts of Dodonaea viscosa for acclaimed antinociceptive activity on chemical and thermal induced pain. Materials and methods: Three experimental pain models viz. thermal stimulation by hot plate method, tail flick method using analgesiometer and writhing induced by glacial acetic acid were used for assessing antinociceptive activity of D. viscosa. Results: All the leaf extracts of D. viscosa showed antinociceptive activity in rats and mice. Conclusion: All tested extracts showed significant antinociceptive activity, among them ethyl acetate extract exhibited superior activity. Data suggests that the extracts of D. viscosa have an inhibitory activity on both peripheral and central pain mechanisms. The antinociceptive efficacy of the extracts may be attributed to the presence of flavonoids, sterols and saponins.

Keywords

Dodonaea viscosa, Antinociceptive Activity, Ethyl Acetate Extract

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A. M. Krupanidhi , H. M. Vagdevi , C. S. Shreedhara , V. P. Vaidya , K. S. Muralikrishna

Abstract

Objective: To study the neuropharmacological activities of the ethanolic extract of Dodonaea viscosa seeds. Materials and methods: Neuropharmacological activities includes behavioural assessment, pentobarbitone-induced sleeping time, motor coordination activity and locomotor activity of the Dodonaea viscosa seeds ethanolic extract was evaluated at the dose of 30 mg/kg and 20 mg/kg (p.o.) respectively. Results: Ethanolic extract of Dodonaea viscosa seeds potentiated phenobarbitone - induced sleeping time, reduced locomotion and the same extract did not induce motor in coordination at dose levels of 30 mg/kg and 20 mg/kg (p.o.). Conclusion: The results of present study have revealed that the ethanolic extract of Dodonaea vsiscosa showed excellent neuropharmacological activities and there is a scope for further envisage.

Keywords

Dodonaea viscosa Seeds, Ethanolic Extract, Hypnosis, Rotarod, Actophotometer

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