Journal of Natural Remedies

M. Chitra , C. S. Shyamala Devi , E. Sukumar

Abstract

Objective: To investigate the changes taking place in the carbohydrate moieties of the glycoprotein in plasma, liver and kidney of the tumour-bearing rats on embelin treatment. Materials and methods: Fibrosarcoma was induced to three groups of animals by injecting the tumour cell line. To two groups, embelin was administered after the tumour became palpable, in two doses (50 and 100 mg/kg) continuously, for 20 days. On 21st day, the animals were sacrificed, blood collected and liver and kidney separated. Total hexose, hexosamine and sialic acid in plasma, liver and kidney tissues were estimated. Results: In tumour-bearing control animals, the above parameters in plasma, liver and kidney tissues were elevated. Continuous administration of embelin lowered these values to near normal. Conclusion: Embelin significantly reversed the elevated levels of carbohydrate moieties of glycoprotein in tumour-bearing rats. This further supports the anti-tumour property of embelin.

Keywords

Embelin, Fibrosarcoma, Carbohydrate Moieties of Glycoprotein

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P. Srinivasan , K. E. Sabitha , C. S. Shyamala Devi

Abstract

Objective: 4-Nitroquinoline-1-oxide (4-NQO), a potent experimental oral carcinogen produces intracellular oxidative stress, which leads to lipid peroxidation following hepatotoxicity. Green tea contains high content of polyphenols, which are potent antioxidants. Thus, green tea can play a protective role in liver damage and hepatotoxicity. In the present investigation it was decided to study the efficacy of Green tea polyphenols(GTP) against 4-NQO induced hepatotoxicity. Materials and methods: Hence, the activity of hepatic markers such as Aspartate Transaminase (AST), Alanine Transaminase (ALT) Lactate Dehydrogenase (LDH) and Alkaline Phosphatase (ALP) in the liver homogenate were assessed and the liver histology were studied. Results: Histology showed cohesive focal necrosis of hepatocytes. A significant increase was observed in all the markers of hepatic function. On administration of GTP for 30 days, a marked decrease in the activity of markers was observed and a lesser degree of necrosis was found in the histology. Conclusion: We conclude that the changes in the activity of markers and histology could be attributed to the therapeutic efficacy of GTP.

Keywords

Green Tea Polyphenols, Hepatoxicity, 4-Nitroquinoline-1-oxide, Oral Carcinogen, Hepatic Markers

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