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Majumder, Alpana
- 5α-Reductase Inhibitory Potential of Hibiscus rosa sinensis: Effective for the Management of Alopecia
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PDF Views:85
Authors
Arpan Chakraborty
1,
Arka Bhattacharjee
1,
Baishakhi Mondal
1,
Manas Chakraborty
2,
Goutam Mukhopadhyay
3,
Alpana Majumder
4
Affiliations
1 Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia, West Bengal - 741249, IN
2 Department of Pharmaceutical Technology, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Howrah, West Bengal - 711 316, IN
3 Department of Pharmaceutical Technology, BCDA College of Pharmacy and Technology (Campus 2), Kolkata, West Bengal - 700129, IN
4 Department of Kayachikitsa, Institute of Post Graduate Ayurvedic Education and Research, Kolkata, West Bengal - 700009, IN
1 Department of Pharmaceutical Technology, Maulana Abul Kalam Azad University of Technology, Nadia, West Bengal - 741249, IN
2 Department of Pharmaceutical Technology, Calcutta Institute of Pharmaceutical Technology and Allied Health Sciences, Howrah, West Bengal - 711 316, IN
3 Department of Pharmaceutical Technology, BCDA College of Pharmacy and Technology (Campus 2), Kolkata, West Bengal - 700129, IN
4 Department of Kayachikitsa, Institute of Post Graduate Ayurvedic Education and Research, Kolkata, West Bengal - 700009, IN
Source
Journal of Natural Remedies, Vol 23, No 2 (2023), Pagination: 467-474Abstract
The condition known as male pattern hair loss and benign prostatic hyperplasia are both treated with a family of drugs known as 5 alpha reductase (5α-reductase) inhibitors. This study shows that the flower of Hibiscus rosa sinensis has 5α-reductase inhibitory action that is helpful in the treatment of androgenic diseases. Phytochemical screening was done using petroleum ether, methanol, and water extracts to identify the phytochemical group present. Then, using quercetin as a reference flavonoid component, the Total Flavonoid Content (TFC) was assessed using a colorimetric technique. The 5α-reductase inhibitory activity was evaluated using several extracts and compared to the well-known 5α-reductase inhibitor finasteride. Finally, the inhibition of different extracts to the enzyme was assessed using a biochemical approach to measure the activity of 5α-reductase. It was determined that the IC<sub>50</sub> value of Hibiscus rosa sinensis methanolic extract, 146.048 ± 0.453 (μg/mL) and quercetin (a chemical biomarker of the plant material) 141.426 ± 1.578 (μg/mL), were promising candidates for future investigation into their antiandrogenic activities.Keywords
Alopecia, Hair Loss, Hibiscus rosa sinensis, NADPH, Quercetin, 5α-Reductase.Full Text
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