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Effect of Leaf Galls of Piper nigrum Linn. Against Carageenan Induced Inflammation in Albino Rats
Objective: To evaluate the anti-inflammatory activity of leaf galls of Piper nigrum Linn. against the carageenan induced paw oedema in Albino rats. Materials and methods: The benzene, chloroform and ethanol extracts of leaf galls of Piper nigrum Linn. were obtained by continuous soxhlet extraction. Each extract was assessed for anti-inflammatory activity in carageenan induced Albino rats by measuring the paw volume and ulcerogenic activity was also carried out. Results: All the extracts showed significant (P<0.05) anti-inflammatory activity in which ethanol extract showed prominent (P<0.01) effect. The extracts were devoid of ulcerogenic action. Conclusion: From the results, it is revealed that, the active ethanol extract of leaf galls of Piper nigrum is worthwhile to develop the bioactive principle for inflammatory disorders.
Piper nigrum, Antiinflammatory, Ulcerogenic
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