The PDF file you selected should load here if your Web browser has a PDF reader plug-in installed (for example, a recent version of Adobe Acrobat Reader).

If you would like more information about how to print, save, and work with PDFs, Highwire Press provides a helpful Frequently Asked Questions about PDFs.

Alternatively, you can download the PDF file directly to your computer, from where it can be opened using a PDF reader. To download the PDF, click the Download link above.

Fullscreen Fullscreen Off

Objective: To investigate the hypoglycaemic and anti-diabetic activities of ethanolic extraxts of leaves of Setaria megaphylla. Materials and Methods: The hypoglycaemic activity of the ethanolic leaves extract was evaluated in normal as well in as alloxan (150mg/kg 1.p) induced hyperglycaemic rats. Preliminary phytochemical screening and acute toxicity studies of the leaves were carried out. The potency of the ethanolic extract (100, 200 and 300mg/kg b.w. p.o) was evaluated after a single dose (acute study) and after prolonged treatment (chronic study) in normal and alloxan induced diabetic albino rats. The activity of the extract was compared with that of reference drug, chlorpropamide (100mg/kg bw.p.o). The blood glucose level was measured by using a glucometer. Results and Discussion: The extract produced a significant (P < 0.01) reduction in Blood glucose level (BGL) of both normal and diabetic rats after a single dose of the extract and in prolong treatment (i.e. for a week). The hypoglycaemic activity was comparable to that of the reference drug, chlorpropamide. Conclusion: Ethanolic leaves extract of Setaria megaphylla exhibited a significant hypoglycaemic activity in rats and this confirms it's use in ethnomedical diabetic management.


Setaria megaphylla, Hypoglycaemic, Anti-diabetic, Alloxan
Font Size