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Mice administered with different doses of infusion obtained from commercial tea preparations of Momordica charantia fruit and leaf displayed variable hypoglycemic activity. M. charantia fruit tea extract at 100 mg/kg BW had demonstrated significant (P=0.001) blood glucose lowering during 0.5h to 1.0h observation period, while M. charantia leaf tea extract was most effective at 100 mg/kg BW with sustained blood glucose reduction pattern starting at 1.5h to 2.5h. The dichloromethane extract of the freeze-dried fruit of M. charantia afforded a mixture of clerosterol (1a) and 5α-stigmasta-7-en-3β-ol (1b) in a 2:1 ratio by silica gel chromatography. A single intraperitonial injection of 10 mg/kg BW of a mixture of 1a and 1b in normoglycemic mice significantly (P<0.05) reduced the blood glucose level with distinct percent blood glucose reduction from 1.5h to 2.0h compared with the negative control.


Momordica charantia, Cucurbitaceae, Hypoglycemic, Clerosterol, 5α-stigmasta-7-en-3β-ol
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