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Background: Piper crocatum, also known as red betel, is a potential herbal medicine. Aims: Current study was planned to determine the antioxidant activities of red betel (Piper crocatum Ruiz and Pav.) leaves extract (RBLE) as compared to eugenol and hydroxychavicol compounds. Methods: DPPH radical scavenging, H2O2 scavenging, ABTS reduction, and FRAP reduction assay were carried out. Results: In DPPH scavenging, RBLE showed an IC50 value of 3.98 μg/mL, eugenol of 2.98 μg/mL, and hydroxychavicol of 18.00 μg/mL. Meanwhile, H2O2 scavenging activity showed an IC50 value of RBLE, eugenol, and hydroxychavicol as 186.33 μg/mL, 97.36 μg/mL, and 41.06 μg/mL respectively. ABTS reduction assay showed an IC50 value of 38.43 μg/mL, 181 μg/mL, and 3.10 μg/mL for RBLE, eugenol, and hydroxychavicol respectively. The highest FRAP reduction activity was shown by Eugenol with a concentration of 50 μg/mL which was equal to 424.67 μM Fe (II)/μg. Conclusion: The RBLE and its compounds (eugenol and hydroxychavicol) have antioxidant activity as indicated by the results of the DPPH scavenging, H2O2 scavenging, ABTS reduction, and FRAP reduction assays. However, RBLE had the lowest antioxidant activity compared to other compounds.


Eugenol, Free Radicals, Hydroxychavicol, Piper crocatum.
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