Journal of Academy of Dental Education

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Stem Cells-A Revolution in Regeneration of the Periodontium:A Review Article


Affiliations
1 Department of Periodontology, K.S.R. Institute of Dental Science and Research, Tiruchengode – 637215, Tamil Nadu, India
 

Stem cells are those units of the living organism that regenerate not just tissues but also organ systems. Their application is bringing about a revolution in the therapeutic world. It will eliminate the drawbacks that older reparative procedures hold. Graft rejection and complications as such are out of question with stem cell therapy. This regenerative therapy is soon to be the future of the therapeutic world. Periodontium comprises of bone, cementum and periodontal ligament making it a complex framework. Regeneration of this becomes a challenge. Stem cell therapy brings a whole new platform to the regeneration of this complex apparatus.

Keywords

Culture, Mesenchymal Stromal Stem Cells, Regeneration.
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  • Bassir SH, Wisitrasameewong W, Intini G. Potential for stem cell based periodontal therapy. J Cell Physiol. 2016 Jan; 231(1):50–61. https://doi.org/10.1002/jcp.25067 PMid:26058394 PMCid:PMC4627700

  • Evans MJ, Kaufman MH. Establishment in culture of pluripotential cells from mouse embryos. Nature. 1981; 292:154–6. https://doi.org/10.1038/292154a0

  • Thomson JA, Itskovitz-Eldor J, Sharpiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM. Embryonic stem cell lines derived from human blastocysts. Science. 1998 Nov 6; 282(5391):1145–7. https://doi.org/10.1126/science.282.5391.1145 PMid:9804556

  • Kim JH, Auerbach JM, Rodriguez- Gomez JA, Velasco I, Gavin D, Lumelsky N, Lee SH, Nguyen J, Sanchez, Pernaute R, Bankiewicz K, McKay R. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson’s disease. Nature. 2002 Jul 4; 418(6893):50–6 https://doi.org/10.1038/nature00900 PMid:12077607

  • Miura M, Gronhos S, Zhao M, Lu B, Fisher W, Robey PG, Shi S. SHED: Stem cells from Human Exfoliated Deciduous teeth.

  • Seo BM, Miura M, Gronthos S, Bartold PM, Batouli S, Brahim J, Young M, Robey PG, Wang CY, Shi S. Investigation of multipotent postnatal stem cells from human periodontal ligament. Lancet. 2004 Jul 10-16; 364(9429):149–55. https://doi.org/10.1016/S0140-6736(04)16627-0

  • Handa K, Saito M, Yamauchi M, Kiyono T, Sato S, Teranaka T, Sampath Narayanan A. Cementum matrix formation in vivo by cultured dental follicle cells. Bone. 2002 Nov; 31(5):606–11. https://doi.org/10.1016/S87563282(02)00868-2

  • Lin H, Gronthos S, Bartold PM. Stem cells and future periodontal regeneration. Periodontol 2000. 2009; 51:239– 51. https://doi.org/10.1111/j.1600-0757.2009.00303.x PMid:19878478

  • Yu J, Thomson JA. Embryonic Stem cells. Stem Cell Information.

  • Hynes K, Menicanin D, Gronthos S, Bartold PM. Clinical utility of stem cells for periodontal regeneration. Periodontol 2000. 2012 Jun; 59(1):203-27. https://doi.org/10.1111/j.1600-0757.2012.00443.x PMid:22507067

  • Sanz AR, Carrion FS, Chaparro AP. Mesenchymal stem cells from the oral cavity and their potential value in tissue engineering. Periodontol 2000. 2015 Feb; 67(1):251–67 https://doi.org/10.1111/prd.12070 PMid:25494604

  • Siddharth M, Varshney S, Singla A, Jagadeesh HG. Stem cells- A window to periodontal regeneration.

  • Huynh NC, Le SH, Doan VN, Ngo LTQ, Tran HLB. Simplified conditions for storing and cryopreservation of dental pulp stem cells. Arch Oral Biol. 2017 Dec; 84:7481 https://doi.org/10.1016/j.archoralbio.2017.09.002 PMid:28957734

  • Nagatomi K Komaki M, Sekiya I, Sakaguchi Y et al. Stem cell properties of human periodontal ligament cells. J Periodontal Res. 2006 Aug; 41(4):303–10. https://doi. org/10.1111/j.1600-0765.2006.00870.x PMid:16827724

  • Bartold PM, Shi S, Gronthos S. Stem cells and periodontal regeneration. Balkan J Med Genet. 2013 Jun; 16(1):7–12. https://doi.org/10.2478/bjmg-2013-0012 PMid:24265588 PMCid:PMC3835291

  • Kawaguchi H, Hitachi A, Hasegawa N, Iwata T, Hamaguchi H, Shiba H, Takata T, Kato Y, Kurihara H. Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal cells. J Periodontol. 2004 Sep; 75(9):1281–7. https://doi.org/10.1902/jop.2004.75.9.1281 PMid:15515346

  • Hasegawa N, Kawaguchi H, Hirachi A, Takedda K, Mizuno N, Nishimura M, Koike C, Tsuji K, Iba H, Kato Y, Kurihara H. Behavior of transplanted bone marrow- derived mesenchymal stem cells in periodontal defects. J Periodontal. 2006 Jun; 77(6):1003–7. https://doi.org/10.1902/jop.2006.050341 PMid:16734575

  • Li H, Yan F, Lei L, Li Y, Xiao Y. Application of autologous cryopreserved bone marrow mesenchymal stem cells for periodontal regeneration in dogs. Cells Tissues Organs. 2009; 190(2):94–101. https://doi.org/10.1159/000166547 PMid:18957835

  • Du J, Shan Z, Ma P, Wang S, Fan Z. Allogenic Bone marrow mesenchymal stem cell transplantation for periodontal regeneration. J Dent Res. 2014 Feb; 93(2):183–8 https://doi.org/10.1177/0022034513513026 PMid:24226426

  • Chen YL, Chen PK, Jeng LB, Huang CS, Yang LC, Chung HY, Chang SC. Periodontal regeneration using ex vivo autologous stem cells engineered to express the BMP-2 Gene: An alternative to alveoloplasty. Gene Ther. 2008 Nov; 15(22):1469–77. https://doi.org/10.1038/gt.2008.131 PMid:18701911

  • Eterela C, et al. Mesenchymal stem cell in dental tissue: perspective for regeneration. Braz Dent J. 2011; 22(2):91–8 https://doi.org/10.1590/S0103-64402011000200001

  • Kawaguchi H, Hirachi A, Hasegawa N, Iwata T, Hamaguchi H, Shiba H, Takata T, Kato Y, Kurihara H. Enhancement of periodontal tissue regeneration by transplantation of bone marrow mesenchymal stem cells. J Periodontal. 2004 Sep; 75(9):1281-7. https://doi.org/10.1902/jop.2004.75.9.1281 PMid:15515346


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  • Stem Cells-A Revolution in Regeneration of the Periodontium:A Review Article

Abstract Views: 461  |  PDF Views: 182

Authors

Karishma Prasanchd
Department of Periodontology, K.S.R. Institute of Dental Science and Research, Tiruchengode – 637215, Tamil Nadu, India
Renuka Devi
Department of Periodontology, K.S.R. Institute of Dental Science and Research, Tiruchengode – 637215, Tamil Nadu, India

Abstract


Stem cells are those units of the living organism that regenerate not just tissues but also organ systems. Their application is bringing about a revolution in the therapeutic world. It will eliminate the drawbacks that older reparative procedures hold. Graft rejection and complications as such are out of question with stem cell therapy. This regenerative therapy is soon to be the future of the therapeutic world. Periodontium comprises of bone, cementum and periodontal ligament making it a complex framework. Regeneration of this becomes a challenge. Stem cell therapy brings a whole new platform to the regeneration of this complex apparatus.

Keywords


Culture, Mesenchymal Stromal Stem Cells, Regeneration.

References





DOI: https://doi.org/10.18311/jade%2F2018%2F22996