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Bhardwaj, Prakash Chandra
- Evaluation of CRP in Patients with Asthma
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Authors
Affiliations
1 Department of Physiology, JIPMER, Puducherry, IN
2 Department of Health Services, Manipur, IN
3 Department of Health Services, Meghalaya, IN
4 Regional Institute of Medical Sciences, Imphal, Manipur, IN
1 Department of Physiology, JIPMER, Puducherry, IN
2 Department of Health Services, Manipur, IN
3 Department of Health Services, Meghalaya, IN
4 Regional Institute of Medical Sciences, Imphal, Manipur, IN
Source
International Journal of Physiology, Vol 8, No 1 (2020), Pagination: 37-42Abstract
Patients with asthma have an ongoing inflammation, which can be assessed by measuring serum C- reactive protein.
Objective: To explore whether CRP could be used as a predictor of disease outcome in asthma. Methods: A Cross-sectional study was conducted among 50 asthma patients attending Respiratory Medicine outpatient services in Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSpheraTM CRP Latex Slide test kit was used to estimate serum C-reactive protein.
Results and Observation: The present study was conducted on fifty asthma patients in which serum CRP level showed association with severity of asthma ( p=0.001) but serum CRP level with spirometric parameters showed significant negative correlation; FVC (r=-0.711, p<0.001), FEV1 (r=-0.665, p<0.001), FEV1/FVC (r=-0.429, p=0.002), FEF25-75% (r=-0.535, p<0.001), and PEFR (r=-0.515, p<0.001).
Conclusion: In our study we found association between serum CRP level and asthma and plasma CRP may be used as a marker of prognosis in patients with asthma.
Keywords
C- Reactive Protein, Asthma.
References
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- Relationship between Smoking and Obstructive Airways Disease
Abstract Views :459 |
PDF Views:0
Authors
Affiliations
1 Department of Physiology, JIPMER, Puducherry, IN
2 Department of Health Services, Manipur
3 DR TB Center, JNIMS Hospital, Imphal, Manipur, IN
4 Regional Institute of Medical Sciences, Imphal, Manipur, IN
1 Department of Physiology, JIPMER, Puducherry, IN
2 Department of Health Services, Manipur
3 DR TB Center, JNIMS Hospital, Imphal, Manipur, IN
4 Regional Institute of Medical Sciences, Imphal, Manipur, IN
Source
International Journal of Physiology, Vol 8, No 1 (2020), Pagination: 43-48Abstract
Obstructive airways disease is an important cause of mortality and morbidity around the world and smoking has a significant role in the development and progression of the disease. Objective: To analyse the relationship between smoking and obstructive airways disease. Method: A cross-sectional study was conducted among 100 patients with obstructive airways disease attending Respiratory Medicine outpatient services in Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. Results and observation: The present study was conducted on 100 patients with obstructive airways disease. The lung function test values of OAD patients showed that FVC, FEV1, and FEV1/FVC values were within normal limits. But FEF25-75%, and PEFR were lower suggesting that smaller airways were affected in obstructive airway disease. In our study we found that OAD was strongly associated with smoking status(p<0.001), smoking pack-years(p=0.000), and smoking duration(p<0.001). Conclusion: From the study results we conclude that that Obstructive airway disease was strongly associated with smoking. Smoking cessation is the best and most effective solution to this problem. Other measures such as screening with spirometric tests in high risk individuals especially the smokers in age group of 40-55 should be considered to reduce the mortality and morbidity due to Obstructive airway disease.Keywords
Obstructive Airways Disease (OAD), Smoking, Spirometric Test.References
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- Koshak EA. Classification of asthma according to revised 2006 GINA: Evolution from severity to control. Ann Thorac Med 2007;2(2):45-6.
- Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2006). Available at: http://www.goldcopd.org. Accessed September 19, 2016.
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