Abstract Views :379 |
PDF Views:0
Authors
Affiliations
1 Department of Physiology, Maulana Azad Medical College, New Delhi, IN
2 Department of Pathology, G B Pant Hospital, New Delhi, IN
3 Department of Physiology, Maulana Azad
Medical College, New Delh, IN
Source
International Journal of Physiology, Vol 2, No 1 (2014), Pagination: 112-117
Abstract
In the present study, the potential of tempol has been examined as a neuroprotective agent against the toxicity of the 6-hydroxydopamine (6-OHDA) in aged rat. Literature is silent about it. Sprague- Dawley rats were pretreated with tempol and subsequently administered the neurotoxin 6-OHDA into the aged rat striatum. Various behavior and immunohistochemical tests were used to evaluate the neuroprotective effect of tempol. Significant difference in various groups was found (ANOVA, p<0.001) in apomorphine-induced rotational behavior, staircase test success rate&disengage time and (ANOVA, p<0.05) in stepping test, initiation time&postural balance test. On the basis of immunohistochemical changes, the present study concludes that tempol is an effective neuroprotective agent for dopaminergic neurons in 6-OHDA induced aged rat model of Parkinson's disease (PD). Aged rats showed less neuroprotection in dopaminergic neurons loss than young rats
Keywords
Tempol, 6-hydroxydopamine And Aged Rat
