International Journal of Physiology

Aparna Garg ¹, D A Biswas ²

Affiliations
1 Assistant Professor, Department of Physiology, Mahatma Gandhi Medical College &Hospital Jaipur Rajasthan
2 Professor and Head, Department of Physiology, Jawaharlal Nehru Medical College, Sawangi (Meghe) Wardha, Maharashtra

Abstract

Introduction: Chronic obstructive pulmonary disease (COPD), the fourth leading cause of death, is a major health problem. COPD has been implicated as one of the causes of peripheral neuropathy. The influence of COPD in the peripheral nervous system has been the subject of clinical investigation only in the recent years. This study aimed at evaluating the nerve conduction velocity (NCV) and amplitude of peripheral motor and sensory nerves of the median and ulnar nerves of the upper extremities in patients of COPD when compared to healthy normal subjects.

Material and Method: The subjects (COPD patients and healthy volunteers) were assessed for anthropometric measurements, the pulmonary function tests and SpO2 levels. They were subjected for the nerve conduction test, of the median and ulnar nerves of the upper extremities

Results: A significant decrease in the NCV and amplitude for the median and ulnar nerves (both the components) at p value < 0.001was found in the COPD patients when compared to the control group, irrespective of the causative factor for COPD.

Conclusion: The presence of peripheral neuropathy was confirmed in COPD patients when compared to healthy control group, as the NCV and amplitudes of peripheral nerves (median and ulnar) of the upper extremities were found to be decreased in COPD patients.

Keywords

Chronic Obstructive Pulmonary Disease, Peripheral Neuropathy, Nerve Conduction Studies

Full Text

     

Nandini Agarwal ¹, V K Deshpande , D A Biswas ², Rashmi Babbar ³

Affiliations
1 Senior Resident,Department of Physiology, Maulana Azad Medical College, New Delhi
2 Head of Department of Physiology, Jawaharlal Nehru Medical College, Sawangi, Wardha
3 Head of Department, Department of Physiology, Maulana Azad Medical College, New Delhi

Abstract

Background: Diabetes mellitus is metabolic disorder of multiple etiologies characterized by chronic hyperglycemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects of insulin secretion, insulin action or both. The study was conducted with an aim to evaluate the effect of type II Diabetes mellitus on auditory brainstem response and conduction velocity of median nerve(motor component) and sural nerve (sensory component) and to correlate between auditory neuropathy and peripheral neuropathy due to type II Diabetes mellitus. The present study was undertaken in the Neurophysiology Laboratory, Department of Physiology, Jawaharlal Nehru Medical College Sawangi(Meghe) Wardha. It was a cross sectional case control study and a total of 100 subjects were studied out of which 50 were diabetics and 50 were age and sex matched controls. Effective nerve stimulation was obtained by the stimulus duration of 50μs to 1000μs and 0-100mA. Supramaximal stimulation (10-30% more than the current)was given. Electrode impedence was kept below 5k. BAEPs were recorded with the help of a computerized evoked potential recording system by monoaural stimulation and all the parameters have been compared at 70dBnHL stimulus intensityThe duration of diabetes in the study group with mean+S.D. is 6.92+2.08 years. There was no statistical significant difference in mean age and gender between the control group andstudygroup We founded increase in latency of waveV and interpeak latency III-V. There was decreased conduction velocity in median nerve and sural nerve of upper limb and lower limbfor motor nerve and sensory nerve respectively

Keywords

Diabetes Mellitus, Brainstem Auditory Evoked Potential, Nerve Conduction Velocity

Full Text