Evaluation of CRP in Patients with Asthma
Patients with asthma have an ongoing inflammation, which can be assessed by measuring serum C- reactive protein.
Objective: To explore whether CRP could be used as a predictor of disease outcome in asthma. Methods: A Cross-sectional study was conducted among 50 asthma patients attending Respiratory Medicine outpatient services in Regional Institute of Medical Sciences (RIMS), Imphal from January 2015 to September 2016. Patients aged 18-67 were included in the study after obtaining Ethical approval from the Research Ethics Board, RIMS, Imphal. Computerized Spirometer Helios 401 was the instrument used to measure lung volumes and capacities. BeneSpheraTM CRP Latex Slide test kit was used to estimate serum C-reactive protein.
Results and Observation: The present study was conducted on fifty asthma patients in which serum CRP level showed association with severity of asthma ( p=0.001) but serum CRP level with spirometric parameters showed significant negative correlation; FVC (r=-0.711, p<0.001), FEV1 (r=-0.665, p<0.001), FEV1/FVC (r=-0.429, p=0.002), FEF25-75% (r=-0.535, p<0.001), and PEFR (r=-0.515, p<0.001).
Conclusion: In our study we found association between serum CRP level and asthma and plasma CRP may be used as a marker of prognosis in patients with asthma.
- Asher MI, Montefort S, Björkstén B, Lai CK, Strachan DP, Weiland SK, et al. Worldwide time trends in the prevalence of symptoms of asthma, allergy rhinoconjunctivitis, and eczema in childhood: ISAAC phases one and three repeat multicountry cross-sectional surveys. Lancet 2006;368(9537):733-43.
- Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease (2006). Available at: http://www.goldcopd.org. Accessed September 19, 2016.
- Bellamy D. Spirometry in practice: a practical guide to using spirometry in primary care. 2nd ed. London: BTS COPD Consortium; 2005.
- Block JL. Evaluation of cardiac injury and function. In: McPherson RA, Pincus MR, editors. Henry`s Clinical Diagnosis and Management by Laboratory Methods. 21st ed. New Delhi: Elsevier; 2009. p. 224-5.
- Sonnenwirth AC. Serological tests in infectious disease-II. In: Sonnenwirth, Jarett L, editors. Gradwohl`s Clinical Laboratory Methods and Diagonosis. 8th ed. New Delhi: B.I. Publications Ltd; 1990. p. 2328-31.
- Koshak EA. Classification of asthma according to revised 2006 GINA: Evolution from severity to control. Ann Thorac Med 2007;2(2):45-6.
- Kony S, Zureik M, Driss F, Neukirch C, Leynaert B, Neukirch F. Association of bronchial hyperresponsiveness and lung function with C-reactive protein (CRP): a population based study. Thorax 2004;59:892–896.
- Olafsdottir IS, Gislason T, Thjodleifsson B, et al. C reactive protein levels are increased in nonallergic but not allergic asthma: a multicentre epidemiological study. Thorax 2005;60:451–454.
- Sävykoski T, Harju T, Paldanius M, et al. Chlamydia pneumoniae infection and inflammation in adults with asthma. Respiration 2004;71:120–125.
- 15. Shimoda T, Obase Y, Kishikawa R, Iwanaga T. Serum high-sensitivity C-reactive protein can be an airway inflammation predictor in bronchial asthma. Allergy Asthma Proc. 2015;36:e23–8.
- M. Takemura, H. Matsumoto, A. Niimi, T. Ueda, H. Matsuoka, M. Yamaguchi, et al. High sensitivity C-reactive protein in asthma. Eur Respire J 2006; 27: 908-912.
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