A. Bolshakov ¹, A. Garapatski ¹, V. Golovkov ¹

Affiliations
1 National Research Tomsk Polytechnic University, 2a, Lenin av., Tomsk – 634050, Russia

Abstract

Background/Objectives: The review techniques for obtaining of 111 In and preparation of indium [111In] chloride, experimental results feasibility study and peculiarity for 111In obtaining for irradiations natCd and enriched 111Cd targets is presented. Methods/Statistical analysis: Some methods for obtaining 111In by means of nat Ag (α, xn) reaction with α particles from 16 to 30 MeV. However the yield 111In in this reaction in several times lesser, than in reaction 111Cd (p, n)111In. Moreover impurity nuclide 109In are resulted in 107Ag (α, 2n) reaction, that takes target cooling within 36 hours before separation 111In. All measured to the present time cross-sections of the reactions to obtain 111In are accumulated in database IAEA. Findings: It was shown, that technical production rate of 111In no less then 627 MBq/h can be provided with using 120 cm cyclotron P7M of Tomsk Polytechnic University. To increase production rate it needs to increase technical yield 111In in the target under irradiation, under its separation from the target and synthesise RPP. Applications/Improvements: 111In is interesting for radionuclide therapies of oncological diseases because it emits Auger electrons having a high linear energy transfer (LET), compared with LET α-particles.

Keywords

Cadmium, Cyclotron, Peculiarities, Radioisotopes, Radio Pharmaceutical Preparations

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A. Baulin ¹, V. Golovkov ¹, A. Bolshakov ¹

Affiliations
1 National Research Tomsk Polytechnic University, 30, Lenin av., Tomsk–634050, Russia

Abstract

Background/Objectives: The main purpose was to measure the effective cross section and yield of 186Re in186W(d, 2n) reaction and estimate possible 186Re production scale at the cyclotron. Methods/Statistical analysis: Square plate of metal tungsten of natural isotopic composition was used as target in measurement of cross section 186W (d,2n)186Re reaction. The plate of tungsten had a thickness of 1.55 mm and square 3,90 × 3, 90 cm2. 40 um titanium foil placed before tungsten target was used as monitor to measure deuteron fluence on the target. Target assemble was irradiated by deuteron beam on Tomsk polytechnic university cyclotron R7M.Deuteron energy accelerated in the cyclotron was 13.6 MeV, outside of cyclotron ion beam line was 13.2 MeV, after monitor foil before falling on the tungsten target was 12.5 MeV. Beam current on the target was about 4 uA, irradiation time - about 15 minutes. After irradiation the target was cooled for 20 min. Findings: It is known that one can obtained 186Re by means of irradiation enriched 185Re targets in a nuclear reactor using (n, γ) reaction. But obtained 186Re contains carrier-added 185Re and have low specific activity, insufficient for use in RIT. To obtain 186Re with high specific activity required for RIT, it is necessary to use charge particle accelerator to get No-Carrier-Added (NCA) nuclides. It was found out that, there are few cross section data for deuteron nuclear reaction with of tungsten nuclei and these data have significant spread. Applications/Improvements: There is a practical need in production of the rapeutic RPP on thebaseof186Re for more using in oncology, anthology and radio immunotherapy (RIT)

Keywords

186Re, MeV Deuterons, Nuclear Medicine, Nuclear Industry, Rhenium, Technetium-99

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