S. Adeleke Adesegun ¹, N. Emmanuel Anyika ², T. Oluseyi Adekoya ³, S. Godwin Essien ³

Affiliations
1 Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, NG
2 Department of Clinical Pharmacy, Faculty of Pharmacy, University of Lagos, NG
3 Department of Pharmaceutical Microbiology, Faculty of Pharmacy, University of Lagos, NG

Abstract

Hallea ledermannii (Krause) Verdc. (Rubiaceae) is used for treatment of various microbial diseases such as dysentery and skin infections. The leaf extract was screened for antibacterial activities using agar cup plate method against pathogenic organisms like Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa and Klebseilla pneumonia. The extract was active against both Gram positive and Gram negative bacteria with MIC value of 50.0, 12.5, 50.0, 18.75 and 12.5 mg/ml respectively. The antioxidant activities of the extract were also determined using total phenolic content and DPPH radical scavenging effect. The content of phenolic compounds in terms of gallic acid was found to be 88.0 mg/g. and scavenging power was found to increase with concentration. These may be responsible for the observed antimicrobial properties of the extract thus justifying its use in traditional medicine for treatment of microbial infections.

Keywords

Antibacterial, Antioxidant, Medicinal Plants, Radical Scavenging Effect

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