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Kumar, Rajesh
- Search for Antihyperglycemic Activity in few Marine Flora and Fauna
Abstract Views :548 |
PDF Views:134
Authors
Priti Tiwari
1,
Neha Rahuja
1,
Rajesh Kumar
2,
Vijay Lakshmi
2,
Mahendra Nath Srivastava
3,
Suresh Chandra Agarwal
3,
Ram Raghubir
4,
Arvind Kumar Srivastava
1
Affiliations
1 Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, IN
2 Medicinal and Process Development Chemistry, Central Drug Research Institute, Lucknow-226001, IN
3 Botany, Central Drug Research Institute, Lucknow-226001, IN
4 Pharmacology, Central Drug Research Institute, Lucknow-226001, IN
1 Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, IN
2 Medicinal and Process Development Chemistry, Central Drug Research Institute, Lucknow-226001, IN
3 Botany, Central Drug Research Institute, Lucknow-226001, IN
4 Pharmacology, Central Drug Research Institute, Lucknow-226001, IN
Source
Indian Journal of Science and Technology, Vol 1, No 5 (2008), Pagination: 1-5Abstract
Evaluation and identification of some new natural molecules with antidiabetic property have become one of the major preludes of present day diabetic research. Although few marine natural products are currently in the market or in the clinical trials, marine organisms still remains the greatest unexploited source of potential pharmaceuticals. Because of the unusual diversity of chemical structures isolated from marine organisms, there is intense interest in screening marine natural products for their biomedical potential. Over 300 marine organisms including flora and fauna were collected at the Institute and extracted with methanol. Their extracts were evaluated for blood glucose lowering effect. The present study reports activity profile of 30marine flora/fauna evaluated in sucrose loaded rat model. Among the marine flora , extracts of Dolichandrone, Amoora cuculata, Chaetomorpha torta, Lumnitzera racemosa, Barringtonia racemosa and Excoecaria agallocha Microciona aceratoobtusa and mollusc Scapharca inaequivalvis at 250 mg/kg body weight dose showed slight but insignificant lowering in the blood glucose post sucrose load in normal rats, whereas, the extract of Cynometra ramiflora showed significant inhibition at the same dose . Among the marine fauna the extracts of soft coral Lobophytum pauciflorum, Sarcophyton glaucum and the extracts of sponge Sigmadocia pumila, showed a little but insignificant lowering in blood glucose post sucrose load in normal rats at 250 mg/kg body weight dose.Keywords
Antihyperglycaemic Activity, Marine Flora, Marine Fauna, Oral Glucose Tolerance TestFull Text
References
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- Modulation of Delayed Type Hypersensitivity Response by Skin Peptide from Rana tigerina
Abstract Views :388 |
PDF Views:103
Authors
Abha
1,
Rajesh Kumar
1
Affiliations
1 Center of Advanced Studies in the Life Sciences, Faculty of Life Science, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, U.P., IN
1 Center of Advanced Studies in the Life Sciences, Faculty of Life Science, Chhatrapati Shahu Ji Maharaj University, Kanpur-208 024, U.P., IN
Source
Indian Journal of Science and Technology, Vol 4, No 11 (2011), Pagination: 1510-1516Abstract
Peptide obtained from skin of Rana tigerina is a small, cationic peptide with antimicrobial activity and recently also reported for their anti cancerous and immunomodulatory properties. Here, we present the immunomodulatory effect of skin peptide from R. tigerina on the antigen presentation activity of macrophages and its correlations in induction of strong DTH response. 2, 4-dinitro-1-flurobenzene (DNFB) sensitized tumour bearing and normal mice were injected with skin peptide of R. tigerina to examine appearance of DTH response. Findings of present study showed that the skin peptides from R. tigerina augment antigen presenting activity of macrophages and maximum DTH response occurred at 48th hrs after antigenic challenge. This study also suggest that the PKC plays major role behind the augmentation of macrophage activity and in turn DTH reaction, as observed by enhanced PKC translocation from cytosol towards membrane. Present endeavor suggests that this peptide can potentially enhance cell mediated immune response. These findings can be used to construct synthetic peptides with desirable modifications to fight cancer and other therapeutic conditions.Keywords
Antigen Presenting Cell, Dnfb, Dth, Frog Skin Peptide, T-cells, R. tigerinaFull Text
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- STH: a Highly Scalable and Economical Topology for Massively Parallel Systems
Abstract Views :301 |
PDF Views:100
Authors
Affiliations
1 Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, U.P. – 202002, India
2 School of Mathematics and Computer Applications, Thapar University Patiala, P.B. – 147004, India
1 Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, U.P. – 202002, India
2 School of Mathematics and Computer Applications, Thapar University Patiala, P.B. – 147004, India
Source
Indian Journal of Science and Technology, Vol 4, No 12 (2011), Pagination: 1737-1748Abstract
Highly parallel systems are receiving significant attention to solve the large and complex problems. This has resulted in the emergence of many attractive interconnection network topologies. This paper introduces a new processor interconnection topology called STH (Scalable Twisted Hypercube) to counter the poor scalability of twisted hypercube. Its suitability for use as multiprocessor interconnection networks has also been explored. The various properties of the proposed topology have been analyzed and it has been compared with some other highly scalable topologies of interest on a number of interconnection networks evaluation parameters. With reduced diameter, better average distance, low traffic density, low cost, maximum number of links, high bisection width and tremendous scalability, STH is more suitable for Massively Parallel Systems. Procedures for routing and broadcasting on the proposed topology have also been discussed and a simple routing algorithm has been presented. The proposed interconnection network provides a great architectural support for parallel computing due to the concurrent existence of multiple LST(m) and TQn.Keywords
Parallel Systems, Processor Topology, Scalability, LST, RoutingFull Text
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