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Chellaram, C.
- Anti-inflammatory Potential of Coral Reef Associated Gastropod, Drupa Margariticola
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Authors
Affiliations
1 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. R.R. Dr. S.R. Engineering College, Avadi. Chennai-600 062, IN
2 Suganthi Devadason Marine Research Institute, Tuticorin-628 001. Tamil Nadu
1 Department of Biomedical Engineering, Vel Tech Multi Tech Dr. R.R. Dr. S.R. Engineering College, Avadi. Chennai-600 062, IN
2 Suganthi Devadason Marine Research Institute, Tuticorin-628 001. Tamil Nadu
Source
Indian Journal of Science and Technology, Vol 2, No 2 (2009), Pagination: 75-77Abstract
The anti-inflammatory effect of the 100% acetone column purified extracts of gastropod, Drupa margariticola was experimented on albino rats shown promising result. The acute toxicity was noted, the LD50 was found to be 375 mg/kg in 48 hrs of observation. Oral administration of doses up to 0.75g/kg did not show any toxic symptoms and did not provoke any significant change in their general behavior. The extract of D. margariticola at the concentration of 50 and 100mg/kg, p.o showed significant decrease in the paw thickness, 36.5 and 72.9 % respectively at the 5th hour of the experiment. The 100% column fraction of D. margarticola is potent inhibitors of exudative and proliferate phase of inflammation and might have provided valuable information with respect to the efficacy and safety of these compounds, when compared to standard drug, Diclofenac sodium. So it can be inferred that, upon further purification, these gastropod extract may be more potent than the standard drug. The 100% acetone column-purified fraction of Drupa margariticola has possible anti-inflammatory effect.Keywords
Anti-inflammatory Drug, Mollusc, ReefFull Text
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- Phytochemical Screening, Quantification of Total Phenols, Total Flavonoids and Antimicrobial Activity of Stem Extracts of Salacia Oblonga
Abstract Views :189 |
PDF Views:0
Authors
Affiliations
1 Sathyabama Institute of Science and Technology, Chennai – 600119, Tamil Nadu, IN
2 Vel Tech Multi Tech Dr. Rangarajan and Dr. Sakunthala Engineering College, Chennai – 600 062, Tamil Nadu, IN
1 Sathyabama Institute of Science and Technology, Chennai – 600119, Tamil Nadu, IN
2 Vel Tech Multi Tech Dr. Rangarajan and Dr. Sakunthala Engineering College, Chennai – 600 062, Tamil Nadu, IN
Source
Indian Journal of Science and Technology, Vol 11, No 23 (2018), Pagination: 1-8Abstract
Salacia oblonga, an endangered medicinal plant widely used for the traditional ayurvedic medicine, belonging to the family Clastraceae. Our present investigation revealed the preliminary phytochemical analysis, total phenols, total flavonoids and antimicrobial activities of aqueous stem extract of salacia oblonga. The stem extracts were prepared by using the solvents like ethanol, acetone, petroleum ether, chloroform and water. Preliminary screening of the extracts was carried out by standard procedures. Among the five different solvents, the aqueous stem extract shown more positive for the availability of natural chemical components. Total phenols and total flavonoids were quantified as 35.63 mg GAE/g and 19.82mg QE/g respectively. The aqueous stem extract was tested against the micro-organisms (Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa, Staphylococousaureus and Escherichia coli). Among the micro-organisms Bacillus subtilis shown maximum zone of inhibition (13.2mm) at a concentration of 30mg/ml of aqueous stem extract of salaciaoblonga. But Escherichia coli inactive against the stem extract.Full Text
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