Refine your search
Collections
Co-Authors
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Srivastava, Arvind K.
- Mild Antihyperglycaemic Activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula
Abstract Views :718 |
PDF Views:146
Authors
Rehan Ahmad
1,
Swayam Prakash Srivastava
2,
Rakesh Maurya
3,
S. M. Rajendran
4,
K. R. Arya
4,
Arvind K. Srivastava
1
Affiliations
1 Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001, IN
2 Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001
3 Medicinal Chemistry, Central Drug Research Institute, Lucknow-226001, IN
4 Botany, Central Drug Research Institute, Lucknow-226001, IN
1 Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001, IN
2 Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001
3 Medicinal Chemistry, Central Drug Research Institute, Lucknow-226001, IN
4 Botany, Central Drug Research Institute, Lucknow-226001, IN
Source
Indian Journal of Science and Technology, Vol 1, No 5 (2008), Pagination: 1-6Abstract
The ethanolic extracts of different parts of the following plants viz. Eclipta alba Hassk (Asteraceae) whole plant, ischolar_mains of Berberis aristata DC (Berbidaceae), stem wood of Betula utilis D. Don (Betulaceae), stem wood of Cedrus deodara (Pinaceae), and fruits of Myristica fragrans Houtt. (Myristcaceae) exhibited 7.5, 8.3, 9.2, 6.0, and 8.7% significant fall in blood glucose profile in a single dose experiment on Streptozotocin-induced diabetic rats. In single dose experiment nearly 8.0% decline in blood glucose profile of Streptozotocininduced diabetic rats was observed with a known antidiabetic ethanolic extract of the fruits of Terminalia chebula (Gaertn.) Retz. (Combretaceae).Keywords
Antidiabetic Plants, Antihyperglycaemic Activity, Streptozotocin, Diabetes, Animal ModelsFull Text
References
- ADA Clinical practice recommendation (1997) Screening for diabetes. Diabetes Care, 20 (1), 22-24.
- Anis KV, Rajesh kumar NV and Kuttan R (2001) Inhibition of chemical carcinogenesis by berberine in rats and mice. J. Pharm. Pharmacol, 53, 763-768.
- Ashok TK and Madhushudana RJ (2002) Diabetes mellitus and multiple therapeutic approach of phytochemicals: Present status and future prospects. Curr. Sci, 83(1), 30-38.
- Bailey CJ (1999) Insulin resistance and antidiabetic drugs. Biochem. Pharmacol. 58, 1511-1520.
- Gupta RK, Kesari AN, Murthy PS, Chandra R, Tandon V and Watal G (2005) Hypoglycemic and hypoglycemic effect of ethanolic extract of leaves of Annona squamosa L. in experimental animals. J. Ethnopharmacol. 99, 75–81.
- Jachak SM (2002) Herbal drug as antidiabetics. An overview. CRIPS. 3, 2.
- Larson MO, Wilken M, Gotfredsen CF, Carr RD, Svendsen O and Rolin B (2002) Mild streptozotocin diabetes in the Gottingen minipig. A novel model of moderate insulin deficiency and diabetes. Am. J. Physiol. Endocrinol. Metab. 282, E1342-51.
- Modak M, Dixit, P, Lodhe, J, Ghaskadbi, S and Devasagayam TPA (2007) Indian Herbs and Herbal Drugs Used for the Treatment of Diabetes. J. Clin. Biochem. Nutr., 40, 163-173.
- Pari L and Amarnath Satheesh M (2004) Hypoglycemic activity of Boerhaavia diffusa L.: effect on hepatic key enzymes in experimental diabetes. J. Ethnopharmacol. 91, 109–113.
- Pari L and Latha L (2004) Protective role of Scopari dulcis plant extract on brain antioxidant status and lipid peroxidation in STZ diabetic male wistar rats. BMC Compliment Altern. Med. 4, 16.
- Rajasekaran S, Sivagnanam K, Ravi K and Subramanian S (2004) Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J. Medicinal Food. 7, 61–66.
- Rakieten N, Rakieten ML and Nadkarni MV (1967) Diabetogenic action of streptozotocin. Proc. Soc. Exp. Biol. Med. 126, 201-205.
- Ram A, Lauria P, Gupta R and Sharma VN (1996) Hypolipidaemic effect of Myristica fragrans fruit extract in rabbits. J. Ethnopharmacol. 55(1), 49-53.
- Sabu MC and Kuttan R (2002) Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J. Ethnopharmacol. 81(2), 155-60.
- Saleem A, Husheem M, Harkonen P and Pihlaja K (2002) Inhibition of cancer cell growth by crude extract and the phenolics of Terminalia chebula retz. fruit. J. Ethnopharmacol. 81(3), 327-36.
- Saxena AK, Singh B and Anand KK (1993) Hepatoprotective effects of Eclipta alba on subcellular levels in rats. J. Ethnopharmacol. 40(3), 155-61.
- Shinde UA, Phadke AS, Nair AM, Mungantiwar AA, Dikshit VJ and Saraf MR (1999) Studies on the anti-inflammatory and analgesic activity of Cedrus deodara (Roxb.) Loud wood oil. J. Ethnopharmacol. 65(1), 21- 27.
- Singh AB and Kumar P (2002) Common environmental allergens causing respiratory allergy in India. Indian J. Paediatrics. 69 (3), 245-250.
- Singh B, Saxena AK, Chandan BK, Aganval SG and Anand KK (2001) In vivo hepatoprotectfve activity of active fraction from ethanolic extract of Eclipta alba leaves. Indian J. Physiol. Pharmacol. 45(4), 435-41.
- Sonavane GS, Sarveiya VP, Kasture VS and Kasture SB (2002) Anxiogenic activity of Myristica fragrans seed. Pharmacol. Biochem. Behav. 71 (1-2), 239-44.
- Srinivasan K and Ramarao P (2007) Animal model in type 2 diabetes: An overview. Indian J. Med. Res. 125, 451-472.
- Suguna L, Singh S, Sivakumar P, Sampath P and Chandrakasan G (2002) Influence of Terminalia chebula on dermal wound healing in rats. Phytotherapy Res. 16(3), 227-31.
- Tiwari AK, Srinivas PV, Kumar SP and Rao JM (2001) Free radical scavenging active component from Cedrus deodara. J. Agri. Food Chem. 49 (10), 4642-4645.
- Upadhya S, Shanbhag KK, Suneetha G, Balachandra Naidu M and Upadhya S (2004) A study of hypoglycemic and antioxidant activity of Aegle marmelos in alloxan induced diabetic rats. Indian J. Physiol. Pharmacol. 48, 476–480.
- Antihyperglycaemic Activity of Six Edible Plants in Validated Animal Models of Diabetes Mellitus
Abstract Views :479 |
PDF Views:129
Authors
Affiliations
1 Deptt. of Plant Sciences, M.J.P. Rohilkhand Univ., Bareilly, IN
2 Central Drug Research Institute, Lucknow-226001, IN
1 Deptt. of Plant Sciences, M.J.P. Rohilkhand Univ., Bareilly, IN
2 Central Drug Research Institute, Lucknow-226001, IN
Source
Indian Journal of Science and Technology, Vol 2, No 4 (2009), Pagination: 80-86Abstract
The fruits of edible hypoglycaemic plants of Momordica charantia, dried seeds of Syzigium cumini, seed oil of Aegle marmelos and dried fruit powder of Coccinia indica, dried powder of the ischolar_mains and rhizomes of Curcuma longa and seeds of Trigonella foenumgraecum were tested on normoglycaemic as well as streptozotocin-induced diabetic rats for its antihyperglycaemic efficacy. The investigation confirms the traditional claim of antihyperglycaemic activity in these edible plants.Keywords
Antihyperglycaemic Activity, Momordica Charantia, Coccinia Indica, Syzigium Cumini, Aegle Marmelos, Curcuma Longa, Trigonella Foenum-graecumFull Text
References
- Ammon HPT and Wahl MA (1991) Pharmacology of Curcuma longa. Planta Medica. 57,1–7.
- Anturlikar SD, Gopumadhavan S, Chauhan BL and Mitra SK (1995) Effect of D-400 (Diabecon), a herbal formulation, on blood sugar of normal and alloxaninduced diabetic rats. Indian J. Physiol. Pharmacol. 2 (39), 95-100.
- Arokiyaraj S, Radha R, Martin S and Perinbam K (2008) Phytochemical analysis and anti-diabetic activity of Cadaba fruticosa R.Br. Indian J. Sci. Technol . 1 (6), 1-4. Domain: http://www.indjst.org.
- Arun N and Nalini N (2002) Efficacy of turmeric on blood sugar and polyol pathway in diabetic albino rats. Plant Foods Hum. Nutr. 57, 41–52.
- Atkinson MA and Eisenbarth GS (2001) Type 1 diabetes: new perspectives on disease pathogenesis and treatment, Lancet. 358, 221-229.
- Chaurasia AK, Dubey SO and Ojha JK (1994) Role of Vijaysara and Jarul on insulin dependent diabetes mellitus. Aryavaidyan, 7 (3), 147-152.
- Chopra RN, Chopra IC, Handa KL and Kapur LD (1958) Indigenous Drugs of India. second ed., UN Dhar and Sons Pvt. Ltd. Calcutta.
- Clifford IB and Carolic D (1989) Traditional plant medicines as treatment of diabetes. Diabetes Car. 12, 553-564.
- Das AV, Padayatti PS and Paulose CS (1996) Effects of leaf extract of Aegle marmelos (L.) Correa ex Roxb. On histological and ultra structural changes in tissue of streptozotocin induced diabetic rats. Ind. J. Exp. Biol. 34 (4), 341-345.
- DeFronzo RA (1997).Pathogenesis of type 2 diabetes: metabolic and molecular implication for identifying diabetes genes.Diabetes Rev. 5, 177-267.
- Eigner D and Scholz D (1999) Ferula asa-foetida and Curcuma longa in traditional medicinal treatment and diet in Nepal. J. Ethnopharmacol. 67, 1–6.
- Fournier F (1948) ‘Plantes Medicinales et Veneneuses de France ‘, 495-499 Paris in vol.III.
- Groop LC, Bonadonna RC, DelPrato S, Ratheiser K, Zyck K, Ferrannini E and DeFronzo RA (1989) Glucose and free fatty acid metabolism in non-insulin dependent diabetes mellitus, Evidences for multiple sites of insulin resistance. J. Clin. Invest. 84, 05-
- Grover JK, Vats V, Rathi SS (2000) Antihyperglycemic effects of Eugenia jambolana and Tinospora cardifolia in experimental diabetes and their effects on key metabolic enzymes in carbohydrate metabolism. J. Ethnopharmacology. 73 (3), 461-470.
- Halim Eshrat M and Ali Hussain (2002) Hypoglycemic, hypolipidemic andantioxidant properties of combination of curcumin from Curcuma longa Linn, and partially purified product from Abroma augusta Linn. in streptozotocin induced diabetes. Indian J. Clinical Biochem. 17 (2), 33-43.
- Jamal Ahmad Abdel-Barry, Issa Abed Abdel-Hassan and HH Mohammad Al-Hakiem (1997) Hypoglycemic and Antihyperglycemic effects of Trigonella foenum-graecum leaf in normal and alloxan induced diabetic rats. J. Ethnopharmacology. 58, 149-155.
- Joshi CS, Priya ES and Venkataraman S (2007) Hypoglycemic and antilipidperoxidative effects of a polyherbal formulation, Diakyur, in experimental animal models. J. Health Sci., 53 (6), 734-739.
- Karunanayake EH, Jeevathayaparam S and Tennekoon KH (1990) Effect of Momordica charantia fruit juice on streptozotocin-induced diabetes in rats. J. Ethnopharmacology. 30 (2), 199-204.
- Karunanayake EH, Welihinda J, Sirimanne SR and Sinnadorai G (1984) Oral hypoglycemic activity of some medicinal plants of Sri Lanka. J. Ethnopharmacology. 11 (2), 223-231.
- Khan A, Aktar S and Mehtab H (1980) Treatment of diabetes mellitus with Coccinia indica. Br. Med J. 280, 1044-1046.
- King H, Aubert R and Herman W (1998) Global burden of diabetes, 1995- 2025. Prevalence, numerical estimates and projections. Diabetes Care. 21, 1414-1431.
- Kumar S, Sudheesh S and Vijaylakshmi NR (1993) Hypoglycemic effect of Coccinia indica: Mechanism of action. Planta Med.59, 330-332.
- Lebovitz HE (1997) Alpha-glucosidase inhibitors. Endocrinol. Metab. Clin. North Am. 26, 539-551.
- Lernmark A and Ott J (1998). Sometimes it’s hot sometimes it’s not. Nature Genet. 19, 213-214.
- Mahapatra PK, Pal M, Chaudhari AKN, Chakarborty D and Basu A (1985) Preliminary studies on glycemic effect of Syzigium cumini seeds. IRCS Med Sc. Biochem. 13 (7), 631-632.
- Mitra SK, Gopumadhavan S and Muralidhar TS (1996) Effect of D-400 an ayurvedic herbal formulation on experimentally induced diabetes mellitus. Phytother. Res. 10, 433-435.
- Mutalik S, Chetana M, Sulochana B, Uma Devi P and Udupa N (2005) Effect of Dianex, herbal formulation on experimentally induced Diabetes mellitus. Phytother Res. 19, 409-415.
- Nandakarni KM (1954) Indian Materia Medica Popular Book Depot, Bombay, pp: 750.
- Nandkarni AK (1992) Indian Materia Medica vol. 1. Popular Prakashan, Bombay, pp: 157.
- Pari L and Venkateswaran S (2003) Protective effect of Coccinia indica on changes in fatty acid composition in streptozotocin induced diabetic rats. Pharmazic. 58, 409-412.
- Polonsky KS, Sturis J and Bell GI (1996) Seminar in medicine of both Israel Hospital, Boston, Non-insulin dependent diabetes mellitus– a genetically programme failure of the β-cell compensate for insulin resistance. N. Engl. J. Med., 334, 777-783.
- Ponnachan PT, Paulose CS and Panikkar KR (1993) Effect of leaf extract of Aegle marmelos in diabetic rats. Indian J.Exp. Biol. 31 (4), 345-347.
- Prince OS, Menon VP and Pari L (1998) Hypoglycemic activity of Syzigium cumini seeds: effect on lipid peroxidation in alloxan diabetic rats. J. Ethnopharmacology. 61(1), 1-7.
- Raynolds JEF (1997) Martindale-The extra pharmacopoeia. 30th edn. The pharmaceutical Press: London.
- Rehan Ahmad, Swayam Prakash Srivastava, Rakesh Maurya, Rajendran SM, Arya KR and Arvind K. Srivastava (2008) Mild antihyperglycaemic activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula . Indian J. Sci. Technol . 1 (5), 1-6. Domain: http://www.indjst.org.
- Sajithlal GB, Chittra P and Chandrakasan G (1998) Effect of curcumin on the advanced glycation and cross-linking of collagen in diabetic rats. Biochem. Pharmacol. 56, 1607–1614.
- Seema PV, Sudha B, Padayatti PS, Abraham A and Raghu KG (1996) Paulose C.S., Kinetic studies of purified malate dehydrogenase in liver of streptozotocin diabetic rats and the effect of leaf extract of Aegle marmelos (L.) Correa ex Roxb. Indian J. Exp. Biol. 36 (6), 600-602.
- Shani J, Goldschmied A, Joseph B, Ahronson Z and Suleman FG (1974) Hypoglycaemic effect of Trigonella foenum-graecum and Lupinis termis (Leguminosae) seeds and their major alkaloids in alloxan induced diabetic and normal rats, Archives internationals de pharmacodynamie et de therapie. 210, 27-37.
- Suryanarayana P, Krishnaswamy K and Reddy GB (2003) Effect of curcumin on galactose-induced cataractogenesis in rats. Mol. Vis. 9, 223–230.
- Upadhyay OP, Singh RM and Dutta K (1996) Studies on antidiabetic medicinal plants used in Indian folklore. Aryavaidyan. 9 (3), 159-167.
- Vekateswaran S and Pari L (2003) Effect of Coccinia indica leaves on antioxidant status in streptozotocin induced diabetic rats. J. Ethnopharmacology. 84, 163-168.
- Venkateswaran S and Pari L (2002) Effect of Coccinia indica on blood glucose, insulin and hepatic key enzymes in experimental diabetes. Pharmaceutical Biology. 403, 165–170.