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Gnanamani, A.
- Quality Assessment of Commercial formulations of Tin Based Herbal Drug by Physico-chemical Fingerprints
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Authors
Affiliations
1 Central Leather Research Institute, Chennai, India
2 Central Leather Research Institute, Adyar, Chennai-600020, India
1 Central Leather Research Institute, Chennai, India
2 Central Leather Research Institute, Adyar, Chennai-600020, India
Source
Indian Journal of Science and Technology, Vol 4, No 12 (2011), Pagination: 1710-1714Abstract
The Tin based herbal drug Vanga Parpamis extensively used for treating urino genital infections, Odema, Polydepsia and Dyspepsia effectively. There are no reports of physico chemical fingerprints for the tin based drug available. Proper characterization techniques are required for checking the quality of the commercial samples, in terms of the physical and chemical constitution to meet the expected criteria to support its use worldwide. Two popular commercial brands such drug were characterized and compared in terms of morphology, composition, crystal lattice, and oxidation state of the active metal. Physico-chemical fingerprints were generated for the samples using analytical techniques like Powder X ray crystallography, Scanning Electron Microscopy, Energy Dispersive X ray Analysis and Inductively Coupled Plasma Optical Emission Spectroscopy and Fourier Transformed Infra Red spectroscopy. It was found that the percentage of tin varied drastically in both brands along with a difference in the percentage composition of other elements and surface morphology which would have significant impact on the therapeutic efficacy and pharmacological activity of the drug samples. The current study appropriately substantiated the need for the use of modern analytical techniques in the establishment of quality and safety assurance of such potent drug.Keywords
Metallo Herbal Drug, Vanga Parpam, Tinoxide,quality Control, Fingerprints, StandardisationFull Text
References
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- Solid State Bioprocessing for Scale up of Aspergillus tamari MTCC5152 Lipase and its Degreasing Effect on Cow Hide
Abstract Views :549 |
PDF Views:140
Authors
Affiliations
1 Department of Microbiology, Central Leather Research Institute (CSIR- New Delhi) Adyar, Chennai-600020, IN
1 Department of Microbiology, Central Leather Research Institute (CSIR- New Delhi) Adyar, Chennai-600020, IN
Source
Indian Journal of Science and Technology, Vol 5, No 7 (2012), Pagination: 2978-2983Abstract
To scale up lipase production process, the effects of different oil cakes and oils as substrates in solid state fermentation (SSF) were investigated. Combination of wheat bran (WB) with gingelly oil cake (GOC) and gingelly oil was observed to be suitable medium for the scale up of lipase. Wheat bran and gingelly oil cake in the ratio of 8:2 along with 0.5% gingelly oil showed 998 u/g of lipase activity in perforated steel trays in koji room cultivation. When compared to flask both enamel tray and perforated steel trays in koji room level scale up studies showed an enhanced production by 12.1% and 26.1%, respectively. A combination of gingelly oil cake and wheat bran exhibited bulk production of lipase in the koji room with shorter period of incubation. Application of 3% of Aspergillus tamari lipases offered maximum degreasing in the hide and the results are comparable to the commercial enzymatic process.Keywords
Wheat Bran, Oil Cakes, Lipase, Scale up Production,Aspergillus tamari MTCC5152Full Text
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