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Authors
Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai-400012, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 4 (2010), Pagination: 955-957
Abstract
The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K2CO3 followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS2 and KOH cyclized to give (IV) which on reaction with different acid chloride form 2-(3-pyridoxymethyl)-5-(4- substitutedphenyl)-1,3,4-triazole. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).
Keywords
3-Hydroxy Pyridine, 1,3,4-Oxadiazole, Anti-Bacterial, Anti-Fungal.
