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Y. A. Jaliwala ¹, Neeraj Kumar Bhatt ¹, Neha Chourasia ¹, P. K. Mohanty ¹

Affiliations
1 VNS Institute of Pharmacy, Vidhya Vihar, Nathu Barkheda, Bhopal-462044, MP, IN

Abstract

Delbergia sisso Roxb is a large deciduous tree found throughout India and is used mainly as aphrodisiac, abortifacient, expectorant, anthelmintic and antipyretic. The present study was conducted to assess the antiulcer activity of ethanolic extract of D. sisso Roxb in experimental animals. Ethanolic extract was prepared and administered orally after suspending in normal saline in experimental animals. Antiulcer activity was evaluated by pre treatment of ranitidine as well as in Aspirin Plus Pylorus Ligation test (Antisecretory method), the seperate results showed that the ethenolic extract potently and significantly reduced the score of ulcer, as compared to control animals. Oral administration of ethanolic extract significantly in Ethanol induced ulcer (Cytoprotective method), on the pretreatment of Ranitidine, the marked reduction in gastric lesion(shows significant ulcer inhibition). The cytoprotective action probably stimulate the prostaglandin synthesis, which in turn protect the gastric mucosa. In water immersion plus restraint method several hemorrhagic gastric glandular mucosal ulcers were observed in stress-induced control animals. Significant changes in the ulcer index compared with control by given Ranitidine and Dalbergia sisso Roxb. In conclusion, these results suggest the presence of antiulcer activity in ethenolic extract of bark of Dalbergia sisso Roxb.

Keywords

Dalbergia sisso, Antiulcer, Ranitidine, Ethanolic Extract, Gastric Secretion.

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P. K. Mohanty ¹, Neha Chourasia ¹, Neraj Kumar Bhatt ¹, Y. A. Jaliwala ¹

Affiliations
1 VNS Institute of Pharmacy, Nathu Barkheda, Bhopal-462044, MP, IN

Abstract

The seeds and leaves of Cajanus cajan Linn.which is a shrub cultivated in Central India are used in medicine belong to the family Fabeaceae. Its application in anti-ulcer, wound healing, hepatoprotective, anti-asthamatic ailments is practiced by the villagers. From extensive literature survey it was revealed that no reports were available on macroscopic as well as pytochemical standardization parameters of Cajanus cajan Linn.in order to check the identity and purity of the drug. The present study aimed to establish methods for quality control of drugs, botanical evaluation which comprises of macroscopy, physicochemical parameters like loss on drying, extractive values, Ash values and to investigate the phytochemicals present in the extracts in the preliminary level with respect tochemical tests and thin layer chromatography. Thus it was thought worthwhile to explore this videly cultivated plant on the basis of it's standardization parameters .The study will provide referential information for the better understanding the plant to be used as medicine for the treatment of the various disease.

Keywords

Cajanus cajan, Fabeaceae, Botanical Evaluation, Phytochemicals, Extractive Values.

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Y. A. Jaliwala ¹, Rahul Chaturvedi ¹, Arvind Rathore ¹, Amit Pandit ², P. K. Mohanty ¹

Affiliations
1 VNS Institute of Pharmacy, Bhopal, (MP), IN
2 School of Pharmacy, Devi Ahilya Vishwavidyalaya, Indore, IN

Abstract

2-Acetoxybenzoic acid suffers from the general side effects of NSAIDs, owing to presence of free carboxylic acid group. The study was aimed to retard the adverse effects of gastrointestinal origin. 4 prodrugs of 2-Acetoxybenzoic acid were synthesized by amidation with ethyl esters of amino acids, namely, glycine, L-phenylalanine, L-glutamic acid, L-aspartic acid. Purified synthesized prodrugs were characterized by m.p., TLC, solubility, elemental analyses, UV, FTIR, NMR. Synthesized prodrugs were subjected for Antypyretic, Analgesic, Anti-inflammatory activities and Ulcerogenic index. Marked reduction of ulcerogenic index and comparable Antypyretic, Analgesic, Anti-inflammatory activities were obtained in all cases as compared to 2-Acetoxybenzoic acid.

Keywords

Prodrugs, Bioavailability, Physical Characterization, Pharmacokinetics, Pharmacodyanamics.

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