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Yogesh Jadhav ¹, Kushal Dawane ¹, Vrushali Patil ¹, A. S. Bobade ¹, S. V. ¹, Abhay Chowdhary ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Acharya Donde Marg, Parel, Mumbai-400012, IN

Abstract

The 3-Hydroxy pyridine on reaction with ethylchloro acetate in presence of K₂CO₃ followed by the reaction with hydrazine hydrate resulted in the formation of 3-pyridoxy acetyl hydrazide (III), which on further the reaction with CS₂ and KOH cyclized to give (IV) which on reaction with different acid chloride form 2-(3-pyridoxymethyl)-5-(4- substitutedphenyl)-1,3,4-triazole. These structures are determined by the elemental analysis and spectral data (IR, 1H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus (ATCC 3750), Salmonella typhi (NCTC 786), Candida albicans (ATCC 10231) and Aspergillus niger (ATCC 16404).

Keywords

3-Hydroxy Pyridine, 1,3,4-Oxadiazole, Anti-Bacterial, Anti-Fungal.

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Ameya G. Yadav ¹, Vrushali Patil ¹, A. S. Bobade ¹, S. V. Athlekar ¹, L. S. Patil ¹, Abhay Chowdhary ¹

Affiliations
1 Department of Chemotherapy, Haffkine Institute for Training, Research and Testing, Parel, Mumbai-400012, IN

Abstract

A series of 2-(1H- benzimidazol-2-ylmercapto)-N-[1,5-dimethyl-2-(substituted) phenyl-3-oxo-2,3-dihydro-1H-pyrazol-4-yl] acyl amines (5a-h) have been synthesized. These structures are determined by the elemental analyses and spectral data (IR, ¹H-NMR). These new derivatives are evaluated for in vitro antimicrobial activity against Staphylococcus aureus ATCC 3750, Salmonella typhi NCTC 786, Candida albicans ATCC 10231 and Aspergillus niger ATCC 16404.

Keywords

Benzimidazole, Pyrazolone, Anti-Bacterial, Anti-Fungal.

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