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Mahanur, Vishal
- A Review on Emerging Oral Dosage Forms which Helps to bypass the Hepatic First Pass Metabolism
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1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati – 444604, IN
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati – 444604, IN
Source
Asian Journal of Pharmacy and Technology, Vol 12, No 1 (2022), Pagination: 47-52Abstract
The initial pass metabolism or pre-circulatory system is a metabolic process in which the concentration of the drug is significantly reduced or shortened in the liver before it reaches the circulatory system. A fraction of the drug lost in the entire absorption process is often associated with the liver and skin wall. Oral delivery, the simplest form of drug management has its limitations, most of which are the low availability of drugs due to the first internal organ passing through metabolism. Drugs with low bioavailability need to be administered at a better dose as a small fraction of the controlled dose is injected into the bloodstream and reaches the target. Therefore, the worst dose of the drug is destroyed and the unauthorized drug ends up having unwanted side effects within the canal. Various forms of oral contraceptives are used. The current review focuses on the importance of passing the first hepatic pass, the biological findings, the reasons for the negative findings and the various methods used to skip the initial hepatic pass metabolism.Keywords
Hepatic First Pass Metabolism, Bioavailability, Novel Drug Delivery System, Low Bioavailability, Gut Wall, Site Targeted
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- Pharmacological Review on Madhuca longifolia
Abstract Views :59 |
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Authors
Affiliations
1 Department of Pharmacology, P. R. Pote Patil College of Pharmacy, Amravati-444604., IN
1 Department of Pharmacology, P. R. Pote Patil College of Pharmacy, Amravati-444604., IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 1 (2022), Pagination: 29-36Abstract
The liver assumes a significant part in keeping up with the metabolic capacity and discharge of poisons from the body. A physical issue or liver brokenness brought about by the utilization of poisonous synthetics, over-the-top liquor and microorganisms bring about a difficult condition called hepatotoxicity. Madhuca longifolia having a place with Sapotaceae family is found to have pharmacological properties in the treatment of different disorders. Madhuca longifolia is likewise considered a therapeutic tree also, is helpful for outside application in treating skin infections, stiffness, migraine, persistent clogging, heaps, hemorrhoids, and ethno clinical properties like antibacterial, anxiolytic qualities, anticancer, hepatoprotective, antiulcer, antihyperglycemic, pain-relieving exercises, and so on. Leaves of mahua are utilized in the treatment of dermatitis, wound mending, anti-burn, bone crack, anthelminthic, emollient, skin illness, stiffness, and cerebral pain. The flowers are used as a tonic, pain-relieving, and diuretic; bark for an ailment, persistent bronchitis, and diabetes mellitus and leaves as an expectorant and constant bronchitis and Cushing's sickness. In this review we make a compilation focused on the synonyms, botanical description, phytochemicals, pharmacological activity, and medicinal uses of Madhuca longifolia.Keywords
Madhuca longifolia, Pharmacology, Anti-anxiety, Phytocompounds, Utilization.References
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- A Review on Magnetic Microspheres- A Novel Drug Delivery System
Abstract Views :64 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati., IN
1 Department of Pharmaceutics, P. R. Pote Patil College of Pharmacy, Amravati., IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 12, No 1 (2022), Pagination: 57-61Abstract
Magnetic microspheres as an alternative to conventional radiation methods which use extremely penetrating radiation that is absorbed throughout the body. Its use is limited by toxicity and side effects. The aim of the specific targeting is to enhance the efficiency of drug delivery and at the same time to decrease the toxicity and side effects. One of its important applications is that it is used for targeting tumors using anticancer drugs. Being more stable, it has an advantage over other delivery systems like liposome. The main objectives of this review are to highlight some important aspects of magnetic microspheres as a novel drug delivery system. The review shall cover definitions, concepts, types, mechanism of targeting, evaluation and characteristics of magnetic microspheres as well as various methods and techniques used in their preparations. The review also entails various applications and future prospects of magnetic microspheresKeywords
Magnetic Microspheres, Preparation, Evaluation, Novel Drug Delivery.References
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