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Guglani, Vishal
- Neonatal Diabetes – A Case Report
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Authors
Affiliations
1 Dept. of Paediatrics, GMCH 32, Chandigarh, IN
2 Assam Medical College, Dibrugarh, IN
1 Dept. of Paediatrics, GMCH 32, Chandigarh, IN
2 Assam Medical College, Dibrugarh, IN
Source
The Indian Practitioner, Vol 71, No 8 (2018), Pagination: 32-34Abstract
Neonatal diabetes mellitus (NDM), defined as persistent hyperglycaemia occurring in the first six months of life, is a rare cause of hyperglycaemia. We report a case of a four-month-old girl child with diabetes presented in Diabetic ketoacidosis (DKA) with severe dehydration, respiratory distress and encephalopathy. The child gradually improved with insulin and fluid therapy. There have been various studies showing the incidence of neonatal diabetes to be around 0.5%. This rare incidence of the disease makes it important to consider neonatal diabetes as an important differential in case of any child presenting with severe dehydration, acidosis and encephalopathy, especially in age group less than 6 months, where the chances of getting it missed are high.Keywords
Neonatal Diabetes, DKA, Sulfonylureas, Subcutaneous Insulin, ABCC8, KCNJ11 Mutations, Transient Diabetes, Permanent Diabetes.References
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- Graves’ Disease In Patient With Down’s Syndrome – Not So Uncommon
Abstract Views :157 |
PDF Views:0
Authors
Affiliations
1 Dept. of Paediatrics, GMCH 32, Chandigarh, IN
2 AMC, Dibrugarh, IN
1 Dept. of Paediatrics, GMCH 32, Chandigarh, IN
2 AMC, Dibrugarh, IN
Source
The Indian Practitioner, Vol 71, No 9 (2018), Pagination: 46-48Abstract
Down’s syndrome (DS) is one of the most common chromosomal disorders (one in 800 births) and the most common cause of mental retardation. It is well known that patients with Down’s syndrome have an increased prevalence of autoimmune disorders, affecting both endocrine and non-endocrine organs. The most common autoimmune disease in Down’s syndrome is related to the thyroid gland. Hyperthyroidism is also found at a higher-than-average rate in patients with DS, although only isolated cases have been reported. We here report a case of a 10-year-old female child showing a rare association between Graves’ and Down’s syndrome. The child had symptoms of anxiety, weight loss and swelling in neck. The symptoms gradually improved with methamizole.Keywords
Down’s Syndrome, Graves’ Diseases, Thyroid, Autoimmune Disease.References
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- American Academy of Pediatrics, Committee on Genetics. Health supervision for children with Down syndrome. Pediatrics. 2001;107:442–9
- Kaguelidou F, Alberti C, Castanet M, Guitteny MA, Czernichow P, Leger J for the French Childhood Graves’ Disease Study Group. Predictors of autoimmune hyperthyroidism relapse in children after discontinuation of antithyroid drug treatment. J ClinEndocrinolMetab 2008; 93: 3817-26.