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Patel, Viral
- Formulation and Evaluation of Delayed Release Pantoprazole Tablets
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Authors
Affiliations
1 Department of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, IN
1 Department of Pharmacy, Shri Jagdish Prasad Jhabarmal Tibrewala University, Vidyanagari, Jhunjhunu, Rajasthan, IN
Source
Asian Journal of Research in Pharmaceutical Sciences, Vol 3, No 2 (2013), Pagination: 95-106Abstract
Pantoprazole is a proton pump inhibitor, belongs to group of benzimidazole, used for the treatment of gastric and duodenum ulcers. Pantoprazole undergoes degradation in acid medium of the stomach, can be coated with enteric coating polymer that will safely deliver the drug in the small intestine. In this present study an attempt was made to formulate and evaluate pantoprazole as enteric coated tablet. Delayed release tablets of pantoprazole were prepared by wet granulation method using HPMC, Cassava starch and polyvinyl pyrrolidine as polymer, Avicel PH 102 (MCC) as filler and starch as binder. The prepared tablets were evaluated for hardness, weight variation, friability and drug content uniformity and it was found that the results comply with official standards. The prepared tablets were coated using enteric coating polymer such as cellulose acetate phthalate, Eudragit L100 and Drug coat L100 by dip coating method. The in vitro release was studied using pH 1.2 acidic buffer and pH 6.8 phosphate buffer. The in vitro release study revealed that the prepared tablets were able to sustain release drug in to the intestine. The release kinetics studies showed that the release was first order diffusion controlled and then values obtained from the Korsmeyer-Peppas model showed that the release mechanism was super case-II transport. Stability studies indicated that the developed tablets were stable and retained their pharmaceutical properties at room temperature and 40°C / 75% RH for a period of 1 month. The anti-ulcer activity was evaluated by water immersion stress induced ulcer model. The pantoprazole sodium sesquihydrate coated formulations ECF3 at a dose of 10 mg/kg body weight showed a protection index of 100%.Keywords
Pantoprazole, Delayed Release, HPMC, PVP, Cassava Starch.
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- Image Compression Using Wavelets
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Authors
Source
International Journal of Innovative Research and Development, Vol 2, No 4 (2013), Pagination: 871-881Abstract
Image require substantial storage and transmission resources, thus image compression is advantageous to reduce these requirements. The report covers some background of wavelet analysis, data compression and how wavelets have been and can be used for image compression. An investigation into the process and problems involved with image compression was made and the results of this investigation are discussed. It was discovered that thresholding was had an extremely important influence of compression results so suggested thresholding strategies are given along with further lines of research that could be undertaken. Wavelets provide a powerful and remarkably flexible set of tools for handling fundamental problems in science and engineering, such as audio de-noising, signal compression, object detection and fingerprint compression, image de-noising, image enhancement, image recognition, diagnostic heart trouble and speech recognition, to name a few. Here, we are going to concentrate on wavelet application in the field of Image Compression so as to observe how wavelet is implemented to be applied to an image in the process of compression, and also how mathematical aspects of wavelet affect the compression process and the results of it. Wavelet image compression is performed with various known wavelets with different mathematical properties. We study the insights of how wavelets in mathematics are implemented in a way to fit the engineering model of image compression.Keywords
Image Compression, Wavelet Transform, Haar Wavelet, DWT, Vector QuantizationFull Text