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Yadav, Vimal
- An Analytical Approach of Doxofylline:A Review
Authors
1 Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), IN
2 Shri Bhagwan College of Pharmacy, Aurangabad (M.S.), IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 1, No 4 (2011), Pagination: 67-70Abstract
Doxofylline is chemically designated as 7-(1, 3 dioxolone-2-yl methyl) theophylline. Presence of a dioxolane group in position C-7 differentiates it from theophylline. It is a new antibronchospastic drug recently introduced in therapy with pharmacological properties like theophylline; a potent adenosine receptor antagonist. doxofylline do not affect gastric acid secretion; either invivo or in-vitro; unlike theophylline. The lack of side effects with doxofylline indicates that the drug can be used safely and effectively. Some analytical methods for quantitative determination of doxofylline in pharmaceutical formulations like UV-Spectrophotometry, HPLC and LC-MS are reported. The present review deals with the various analytical methods reported as well as adopted for the estimation of doxofylline.Keywords
Doxofylline, UV, HPLC, LC-MS.
- Phytochemical Analysis and Comparative Anticonvulsant Activity of Celastrus Paniculatus Willd. Mes Induced Seizure in Mice
Authors
1 Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), IN
2 Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 5, No 1 (2012), Pagination: 83-86Abstract
The present study evaluated the anticonvulsant potential of petroleum ether and ethanolic extracts seeds of Celastrus paniculatus Willd. On Maximal electroshock and Pentylenetetrazole induce seizures in mice. The extract (petroleum ether and ethanolic) 200 mg/kg, 400 mg/kg, 600 mg /kg were given intraperitonially. The latency of seizures, death time and % mortality were observed. EECP and PECP gave significant protection against MES (Maximal electroshock) and PTZ (pentylenetetrazole) induced convulsion. The p value of PECP in PTZ P < 0.001and MES in PECP P < 0.01, P < 0.001. was statistically significant. Phytochemical Screening of the plant revels the presence of alkaloids, tannins, phenolic compound, fatty acids, steroids and flavonoids. The results indicate a possible efficacy potential of the plant extract of Celastrus paniculatus Willd. in convulsion.
Keywords
Celastrus paniculatus Willd, Phytochemical Convulsion, Maximal Electroshock, Mice.- Phytochemical Analysis and Comparative Anticonvulsant Activity of Celastrus Paniculatus Willd. Mes Induced Seizure in Mice
Authors
1 Kunwar Haribansh Singh College of Pharmacy, Jaunpur (U.P.), IN
2 Institute of Pharmacy, Bundelkhand University, Jhansi (U.P.), IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1553-1556Abstract
The present study evaluated the anticonvulsant potential of petroleum ether and ethanolic extracts seeds of Celastrus paniculatus Willd. On Maximal electroshock and Pentylenetetrazole induce seizures in mice. The extract (petroleum ether and ethanolic) 200 mg/kg, 400 mg/kg, 600 mg /kg were given intraperitonially. The latency of seizures, death time and % mortality were observed. EECP and PECP gave significant protection against MES (Maximal electroshock) and PTZ (pentylenetetrazole) induced convulsion. The p value of PECP in PTZ P < 0.001and MES in PECP P < 0.01, P < 0.001. was statistically significant. Phytochemical Screening of the plant revels the presence of alkaloids, tannins, phenolic compound, fatty acids, steroids and flavonoids. The results indicate a possible efficacy potential of the plant extract of Celastrus paniculatus Willd. in convulsion.