A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Salvi, Vidula
- Analgesic Activity of Roots of Holostemma annulare
Authors
1 Department of Pharmacognosy, Modern College of Pharmacy (For Ladies), Borhadewadi, Dehu-Alandi Road, Tal: Haveli, At Post: Moshi, Pune: 412105 Maharashtra, IN
2 Department of Pharmacognosy, Modern College of Pharmacy (For Ladies), Pune, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 2 (2011), Pagination: 77-80Abstract
In the traditional system of medicines in India, different parts of the plant Holostemma annulare (Roxb) K. Schum (HA) have been traditionally claimed to have medicinal properties. Of this plant 34 medicinal preparations are used. The ischolar_mains of the Holostemma annulare (Roxb) K. Schum have been reported to possess anti inflammatory, anti-spasmodic and anti-diabetic activity without noticable toxicity. The present study has been undertaken in order to evaluate the analgesic activity of alcoholic, aqueous and benzene extract of ischolar_mains of plant Holostemma annulare (Roxb) K. Schum using acetic acid induced writhing test.
The two doses of 300mg/kg and 600mg/kg of body weight were prepared by dissolving in water. A minimum four animals were used for each group including control, standard group receiving drug Diclofenac sodium intraperitoneally and test groups receiving different extracts of Holostemma annulare(Roxb) K. Schum ischolar_mains at doses 300mg/kg and 600mg/kg orally. It was concluded that the aqueous extract of dose 300 mg/body wt. and 600mg/body wt. has shown a significant analgesic activity. Alcoholic and Benzene extract of ischolar_mains were devoid of any analgesic activity at the dose level of 300mg/body wt., but showed a significant analgesic activity at the dose of 600mg/body wt.
In this study the results indicated that the ischolar_mains of the plant Holostemma annulare (Roxb) K. Schum possesses a significant analgesic activity.
Keywords
Holostemma annulare (roxb) K. Schum, Analgesic Activity, Acetic Acid Induced Writhing, Pain.
References
- Schaible, H.G., Richter, F., Patho physiology of pain. Langenbecks Arch Surg, 2004, 389 (4), 237–243. [3].
- Basbaum, A., Bushnell, C., Pain: basic mechanisms: World Congress on Pain (10th, San Diego, Calif) Pain, 2002, 1, 3–7.
- Howland RD, Mycek MJ (2006). Lippincott's Illustration Review: Pharmacology. Harvey, RA, Champe PC (eds.) Lippincott Williams and Wilkins publishers London. pp. 157-168.
- Kumara, N.K.V.M.R., 2001. Identification of strategies to improve research on medicinal plants used in Sri Lanka. In: WHO Symposium. University of Ruhuna, Galle, Sri Lanka.
- DS Reddy IS Muchandi RA Srinivasa HA Pradeep K RaviKumar MS RaoM Ibrahim. Effect of Holostemma annularis on the progression of diabetes induced by a high fructose diet in rats and in diabetic C57BL/6J ob/ob miceDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2010:3 87–94.
- Krishnan Nambiar, V. P. Jayanthi, A. Sabu, T. K. and Rajendrakumar, Pharmacognostical studies on Jivanti (Holostemma annulare Ada-Kodien Schult), Aryavaidyan, Vol. XI, No, Aug-Oct 1997, Page no. 37-5.
- Wealth of India, A Dictionary of Indian Raw Materials and Industrial Products, Raw materials, Vol. V: H- K, National Institute of Science Communication, CSIR, New Delhi, India, 111.
- Warrier, P.K., Nambiar, V.P.K. and Ramankutty, C. 1995. Indian Medicinal Plants: A Compendium of 500 Species Vol.3. Orient Longman, pp. 167-171
- Jelly L, Padikkala J. Chemoprotective effect of Holostemma adakodien Schult. ischolar_main extract on cyclophosphamide induced toxicity. Amala Research Bulletin. 2006;26:183–190.
- Vedhavthy S. Brown gold cultivation in Western Ghats. Natural Product Radiance. 2004;3:4:235–236.
- Ramiah, N., Nair, G.A. and Prasad, N.B.R. 1981. Chemical components of Holostemma annulare K. Schum. J. Sci. Res. PI. Med. 2(3): 76-78.
- Upadhye M, Richard Lobo R, Kumar D, Shirwaiker A. Antioxidant activity of Holostemma annularis in STZ nicotinamide induced type 2 diabetic rats. Abstracts of 58th IPC, 2007; Mumbai-Scientific Poster Presentation (CP74): Pharmacognosy, Indegenous Drugs and Herbal formulations. 2007.
- Upadhye M, Anju Dhiman, Shirwaiker A. Antioxidant activity of aqueous extract of Holostemma annulare (Roxb) K. Schum. Adv. Pharmacol. Toxicol. Vol. 10 (1) 2009, 127-131.
- Shirwaikar A, Punitha ISR, Upadhye M, Dhiman A. Antidiabetic activity of alcohol ischolar_main extract of Holostemma annulare in NIDDM Rat. Pharma Biol. 2007;45:440–445.
- Koster R, Anderson M, De-Beer EJ.Acetic acid analgesic screen. Federation Proc1959;18 : 418-20.
- Guyton AC, Hall JE. Somatic sensations: Pain, headache and thermal sensations. In: Textbook of medical physiology. 11th ed. Bangalore, India, Prism Books, 2006, pp 598–99.
- Hammond DL. Inference of pain and its modulation from simple behaviors. In: Chapaman CR, Loeser JD, editors. Issues in pain management: advances in pain research and therapy. New York: Raven Press; 1989. p. 69–91.
- Vyklicky L (1979) Techniques for the study of pain in animals, in Advances in Pain Research and Therapy (Bonica JJ, Liebeskind JC, and Albe-Fessard DG eds) vol 3, pp 727–745, Raven Press, New York.
- Collier, H.O.J., Dinneen, L.C., Johnson, C.A., Schneider, C., 1968. The abdominal constriction response and its supression by analgesic drugs in the mouse. British Journal of Pharmacology 32, 295–310.
- Deraedt, R., Joughney, S., Delevakee. F. and Falhour, M. (1980). Release of prostaglandin E and F in an algogenic reaction and its inhibition. Eur. J. Pharmacol. 51: 17-24.
- A Review on Ficus hispida
Authors
1 Bharati Vidyapeeth's College of Pharmacy, Sector-8, C.B.D. Belapur, Navi-Mumbai. 400614, IN