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Kulkarni, Venkatrao
- Pharmacodynamic interaction of Terminalia arjuna (Roxb) with Ocimum sanctum (Linn) in Isoproterenol induced cardiac necrosis
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Authors
Chetan Savant
1,
Venkatrao Kulkarni
1,
Prasanna Habbu
2,
Preeti Kulkarni
1,
Muhammed Majeed
3,
Mahadeva Nayak
3
Affiliations
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka, IN
3 Sami Labs Limited, R&D Peenya Industrial Area, Bangalore- 560058, Karnataka, IN
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka, IN
3 Sami Labs Limited, R&D Peenya Industrial Area, Bangalore- 560058, Karnataka, IN
Source
Asian Journal of Pharmaceutical Research, Vol 12, No 1 (2022), Pagination: 19 - 23Abstract
Herbal drugs are used widely even when their biologically active compounds are unknown, probably because of their effectiveness, lesser side effects and affordability. In the present study we investigated the potential cardio- protective effect of combination of standardized extracts of Terminalia arjuna and Ocimum sanctum in isoproterenol induced myocardial infarction. Myocardial infarction was induced in rats by subcutaneous injection of Isoproterenol for two consecutive days at an interval of 24h. Rats were pre-treated with test drugs for the period of 21 days and Isoproterenol was administered on 20 and 21st day. At the end of experiment i.e on 22nd day hemodynamic, biochemical and histopathological study of heart tissue were evaluated from control and experimental groups. Isoproterenol treated animals showed significant increase in heart rate and cardiac biomarkers. Whereas, mean arterial blood pressure and antioxidant parameters were significantly decreased. Animals administered with different combinations of standardized extracts of Terminalia arjuna and Ocimum sanctum significantly maintained the levels of cardiac biomarkers, antioxidant parameters, mean arterial pressure and heart rate. Histopathology study showed marked myocardial necrosis in Isoproterenol treated animals and significant cardiac protection of animals treated with extract combinations. Hence, we may conclude that herb- herb combinations were found to be effective in prevention of myocardial injury induced by isoproterenol.
Keywords
Cardiac necrosis, Isoproterenol, Ocimum sanctum, Terminalia arjuna and Myocardial infarction
References
- Hasitha Diana Manohar, Srinivasan D, Sengottuvelu S. Cardioprotective activity of Limonia acidissima against Isoproterenol Induced Myocardial Infarction in Rats. Research Journal of Pharmacy and Technology. 2016; 9(5): 541-544.
- Malathi Mangalanathan, Saraswathi Uthamaramasamy, Ramalingam Venkateswaran. Protective effect of Zanthoxylum armatum fruit on Heart Mitochondrial Antioxidants Against Isoproterenol Induced Cardiac Damage in Rats. Research Journal of Pharmacy and Technology. 2018; 11(2): 681-686. .
- Wong ZW, Thanikachalam PV and Ramamurthy S. Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review. Biomedicine & Pharmacotherapy. 2017; 94: 1145–1166.
- Khalil M, Ahmmed I, Ahmed R, Tanvir EM, Afroz R and Paul S et. al, Amelioration of isoproterenol-induced oxidative damage in rat myocardium by Withania somnifera leaf extract. BioMed Research International. 2015; 2015: 624159.
- Saiprasanna Behera, Manohar Babu S, Y Roja Ramani, Prasanta Kumar Choudhury, Rajeshree Panigrahi. Cardioprotective Activity of Ocimum canum Hydro-alcoholic Leaf Extracts against Isoproterenol Induced Myocardial Infarction in Rats. Research Journal Pharmacology and Pharmacodynamics. 2012; 4(4): 191- 201.
- Dwivedi S. Terminalia arjuna Wight & Arn. a useful drug for cardiovascular disorders. Journal of Ethnopharmcology. 2007;
- Grassi D, Desideri G, Croce G, Tiberti S, Aggio A and Ferri C. Flavonoids, vascular function and cardiovascular protection. Current Pharmaceutical Design. 2009; 15: 1072-1084.
- Kumar G, Saleem N, Kumar S, Maulik SK, Ahmad S and Sharma M. Transcriptomic validation of the protective effects of aqueous bark extract of Terminalia arjuna (Roxb.) on isoproterenol- induced cardiac hypertrophy in rats. Frontiers in Pharmacology. 2019; 10: 1443.
- Sharma M, Kishore K, Gupta SK, Joshi S and Arya DS. Cardioprotective potential of Ocimum sanctum in isoproterenol induced myocardial infarction in rats. Molecular and Cellular Biochemistry. 2001; 225: 75-83.
- Sivakumar V and Rajeshkumar S. Screening of cardioprotective effect of Terminalia arjuna Linn. bark in isoproterenol-induced myocardial infarction in experimental animals. International Journal of Pharma Sciences and Research. 2014; 5(6): 262-268.
- Tiwari P, Rakesh K Patel. Cardioprotective activity of Ashwagandharishta on Isoproterenol Induced Myocardial Infarction. Research Journal of Pharmacology and Pharmacodynamics. 2012; 4(5): 294-298.
- Sun M and Zigman S. An improved spectrophotometric assay for superoxide dismutase based on epinephrine auto-oxidation. Analytical Biochemistry. 1978; 90: 81–89
- Clairborne A. Catalase activity. In: Greenwald RA, editor. CRS handbook of methods in oxygen radical research. Boca Raton, FL: CRS Press; pp. 283–4. 1991.
- Ellman GL. Tissue sulfhydryl groups. Archives of Biochemistry and Biophysics. 1959; 82: 70–77.
- Preeti Tiwari. Cardioprotective Activity of Draksharishta on Isoproterenol Induced Myocardial Infarction. Research JournalScience and Technology. 2014; 6(3): 151-155.
- Heraldo GLF, Nestor LF, Rafael BS, Eduardo RC and Patrícia LDL. Experimental model of myocardial infarction induced by isoproterenol in rats. The Brazilian Journal of Cardiovascular Surgery. 2011; 26: 469-476
- Acikel M, Buyukokuroglu ME, Erdogan F, Aksoy H, Bozkurt E and Senocak H. Protective effects of dantrolene against myocardial injury induced by isoproterenol in rats: biochemical and histological findings. International Journal of Cardiology. 2005; 98: 389-394.
- Hardik Joshi, Manoj Pagare, Leena Patil, Vilasrao Kadam. Cardioprotective Effect of Ethanolic Extract of Buchanania lanzan Spreng. Against Isoproterenol Induced Myocardial Infarction in Rats: A Biochemical, Electrocardiographic Evaluation. Research Journal of Pharmacy and Technology. 2012; 5(2): 263-266.
- Priscilla DH and Prince PSM. Cardioprotective effect of gallic acid on cardiac troponin-T, cardiac marker enzymes, lipid peroxidation products and antioxidants in experimentally induced myocardial infarction in Wistar rats. Chemico-Biological Interactions. 2009; 179: 118–124.
- Sharma M, Kishore K, Gupta SK, Joshi S and Arya DS. Cardioprotective potential of Ocimum sanctum in isoproterenol induced myocardial infarction in rats. Molecular and cellular biochemistry. 2001; 225(1): 75-83.
- Subbaiah GV, Mallikarjuna K, Shanmugam B, Ravi S, Taj PU and Reddy KS. Ginger treatment ameliorates alcohol-induced myocardial damage by suppression of hyperlipidemia and cardiac biomarkers in rats. Pharmacognosy Magazine. 2017; 13: 69-75.
- Mandal S, Patra A, Samanta A, Roy S, Mandal A, Mahapatra TD, Pradhan S, Das K and Nandi DK. Analysis of phytochemical profile of Terminalia arjuna bark extract with antioxidative and antimicrobial properties. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(12): 960-966.
- Lokhande VY, Yadav AV. In vitro Antioxidant and Antidiabetic Activity of Supercritical Fluid extract of Leaves Ocimum sanctum L. Research Jornal of Pharmacy and Technology. 2018; 11(12): 5376-5378.
- Akila P, Asaikumar L and Vennila L. Chlorogenic acid ameliorates isoproterenol-induced myocardial injury in rats by stabilizing mitochondrial and lysosomal enzymes. Biomedicine & Pharmacotherapy. 2017; 85: 582-591.
- McGill R.M. The past and present of serum aminotransferases and the future of liver injury biomarkers. EXCLI Journal. 2016; 15: 817–828.
- Peer PA, Trivedi PC, Nigade PB, Ghaisas MM and Deshpande AD. Cardioprotective effect of Azadirachta indica A. Juss. on isoprenaline induced myocardial infarction in rats. International Journal of Cardiology. 2008; 26: 123-126.
- Qu L, Zhu Y, Liu Y, Yang H, Zhu C, Ma P, Deng J, Fan D. Protective effects of ginsenoside Rk3 against chronic alcohol- induced liver injury in mice through inhibition of inflammation, oxidative stress, and apoptosis. Food and Chemical Toxicology. 2019; 126: 277-284.
- Screening of Novel Hybrid Combinations of Synthetic Drugs with Plant Extracts for Its in Vitro Antioxidant Activity
Abstract Views :98 |
PDF Views:0
Authors
Chetan Savant
1,
Venkatrao Kulkarni
1,
Preeti Kulkarni
1,
Prasanna Habbu
2,
Muhammed Majeed
3,
Mahadeva Nayak
3
Affiliations
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka,, IN
3 SAMI Labs limited, R&D Peenya Industrial Area, Banglore-560058 Karnataka, IN
1 Department of Pharmacology, SET’s College of Pharmacy, Dharwad-580002, Karnataka,, IN
2 Department of Pharmacognosy, SET’s College of Pharmacy, Dharwad- 580002, Karnataka,, IN
3 SAMI Labs limited, R&D Peenya Industrial Area, Banglore-560058 Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 15, No 1 (2022), Pagination: 188-192Abstract
The present experiment was carried out with the aim to screen selected herb-drug for its antioxidant activity in combination and individually. The antioxidant activity of test samples were estimated by 2,2 Diphenyl -1-picryl hydrazyl (DPPH) radical scavenging activity, hydroxyl radical scavenging activity, reducing power assay. All the selected herb-drug combinations have shown significant antioxidant activity in all three antioxidant procedures compared to individual herb or drug sample. Hence, it may be concluded that herb-drug combinations have better antioxidant potential than alone.Keywords
Tinospora cordifolia, Ocimum sanctum, Terminalia arjuna, Antioxidant activity, Atenolol, Propranolol and Amlodipine.References
- Valko M et al. Free radicals and antioxidants in normal physiological functions and human disease. International Journal of Biochemistry and Cell Biology. 2007; 39: 44‐84.
- Devasagayam TP et al. Free radicals and antioxidants in human health: current status and future prospects. Journal of the Association of Physicians of India. 2004; 52: 794-804.
- Park PJ et al. Purification and characterization of antioxidative peptides from protein hydrolysate of lecithin free egg yolk. Journal of the American Oil Chemists' Society. 2001;78: 651‐656.
- Jain A et al. Phytochemical composition and antioxidant activity of methanolic extract of Ficus benjamina (moraceae) leaves. Research Journal of Pharmacy and Technology. 2013; 6(11): 1184-1189.
- Wiysonge CS et al. Beta-blockers for hypertension. Cochrane database of systematic reviews. 2017(1).
- Kumaraswamy G et al. Development and Validation of a Reversed-Phase HPLC Method For Simultaneous Determination of Aspirin, Atenolol and Amlodipine in Capsules Dosage Forms. Asian Journal of Pharmaceutical Analysis. 2014; 4(3): 116-120.
- Muthukumaran P et al. In vitro Antioxidant Activity of Premna serratifolia Linn. Asian Journal of Research in Pharmaceutical Sciences. 2013; 3(1): 15-18
- Subhrajyoti Roy et al. Assessment of the Antioxidant and Free Radical Scavenging Activities of Methanolic Extract of Diplazium esculentum. International Journal of Food Properties. 2013; 16(6): 1351-1370.
- Patel DS et al. Evaluation of In-vitro Anti-oxidant and Free Radical Scavenging activities of Withania somnifera and Aloe vera. Asian Journal of Pharmacy and Technology. 2012; 2(4): 143-147.
- Rao KV et al. Phytochemical composition, antioxidant, antimicrobial and cytotoxic potential of methanolic extracts of Adhatoda vasica (Acanthaceae). Research Journal of Pharmacy and technology. 2013; 6(9): 1004-1009.
- Ghanshyam B et al. Free radical Scavenging and Antioxidant Activity of Punica granatum Linn. Asian Journal of Research in Pharmaceutical Sciences. 2014; 4(2): 51-54.
- Devasagayam TPA, Baloor KK, Mishra KP. Some new methods for free radical research. SFRR-India Bulletin. 2003; 2(2): 20-28.
- Dixit P et al. Antioxidant properties of germinated fenugreek seeds. Phytotherapy Research 19; 2005: 977-983.
- Chatterjee S et al. A modified, economic, sensitive method for measuring total antioxidant capacities of human plasma and natural compounds using Indian saffron (Crocus sativus). Clinica Chimica Acta. 2005; 352(1-2): 155-163.
- Shirwaikar A et al. In vitro antioxidant studies of Sphaeranthus indicus (Linn). Indian Journal of Experimental Biology. 2006; 44: 993-996.
- Mosquera OM et al. Antioxidant activity of twenty five plants from Colombian biodiversity. Memorias do Instituto Oswaldo Cruz. 2007; 102(5): 631-634.
- Villaño D et al. Radical scavenging ability of polyphenolic compounds towards DPPH free radical. Talanta. 2007; 71(1): 230-235.
- Kondragunta K et al. Antioxidant activity and Folic acid content in indigenous isolates of Ganoderma lucidum. Asian Journal of Pharmaceutical Analysis. 2016; 6(4): 213-215.
- Foti MC et al. Electron-transfer reaction of cinnamic acids and their methyl esters with the DPPH• radical in alcoholic solutions. Journal of Organic Chemistry. 2004; 69(7): 2309-2314.
- Gutteridge MC et al. Reactivity of hydroxyl and hydroxyl‐like radicals discriminated by release of thiobarbituric acid reactive material from deoxy sugars, nucleosides and benzoate. Biochemical Journal. 1984; 224: 761−767.
- Spencer JPE et al. Intense oxidative DNA damage promoted by L‐DOPA and its metabolites, implications for neurodegenerative disease. FEBS Letters. 1994; 353(3): 246‐250.
- Malathi R et al. Antioxidant Activity of Extract from the Leaves of Tylophora asthmatica. Asian Journal of Research in Pharmaceutical Sciences. 2012; 2(2): 80-82.
- Geckil H et al. Antioxidant, free radical scavenging and metal chelating characteristics of propolis. American Journal of Biochemistry and Biotechnology. 2005; 1(1): 27–31.
- Sheela S et al. Free Radical Scavenging Activity of Leaves of Memecylon edule Roxb. Research Journal of Pharmacognosy and Phytochemistry. 2009; 1(2): 109-112.
- Matsusighe K et al. Potent free radical scavenging activity of dicaffeoyl quinic acid derivatives from propolis. Journal of Traditional Medicine. 1996; 13: 217–228.
- Jain DP et al. Synergistic antioxidant activity of green tea with some herbs. Journal of advanced pharmaceutical technology and research. 2011; 2(3):177.
- Yang WJ et al. Synergistic antioxidant activities of eight traditional Chinese herb pairs. Biological and Pharmaceutical Bulletin. 2009; 32(6):1021-1026.