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Ravichandiran, V.
- Antiinflammatory Activity of Adenanthera pavonina Linn. Leaves
Authors
Source
Journal of Natural Remedies, Vol 12, No 1 (2012), Pagination: 56-62Abstract
Antiinflammatory activity of Adenanthera pavonina Linn. leaves were evaluated using formalin induced rat paw oedema model for acute inflammation and cotton pellet granuloma model for chronic inflammation. The leaves of the plant was extracted with methanol by cold maceration method. The methanolic extract was fractionated with water. The extract and its aqueous fraction were screened for its anti inflammatory activity at the dose levels of 200mg/kg and 400mg/kg. Compared with control both showed significant activity against acute and chronic inflammation. Aqueous fraction of methanolic extract significantly inhibit the paw oedema in acute model and granuloma formation in chronic model with respect to the methanolic extract. The results indicates that the antiinfammatory activity of Adenanthera pavonina leaf extract could be through a inhibition of elevated prostaglandin biosynthesis and reduction of proliferative mass inflammed cells.The present results of anti inflammatory activity supports the folklore claim of Adenanthera pavonina leaves.Keywords
Adenanthera pavonina, Formalin,cotton Pellet Granuloma, Anti Inflammatory- A Systematic Review on Antidiabetic Medicinal Plants
Authors
1 Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University. P.V. Vaithiyalingam Road, Velan Nager, Old Pallvaram, Chennai.600117, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 5, No 3 (2013), Pagination: 155-168Abstract
Diabetes mellitus is chronic metabolic disorders that affect human body in terms of physical, psychological and social health. It is defined as a group of disorders characterized by hyperglycemia, altered metabolism of lipids, carbohydrates and proteins. The prevalence of diabetes mellitus is expected to reach up to 4.4 % in the world by 2030. Plants are indispensible sources of medicine since time immemorial. Studies on natural products are aimed to determine medicinal values of plants by exploration of existing scientific knowledge, traditional uses, and discovery of potential chemotherapeutic agents. Phytochemicals are used as templates for lead optimization programs, which are intended to make safe and effective drugs. . In this regard, plants provide the best option for search of desired safe and effective medications. Since ancient times, plants have been an exemplary source of medicine. Various plants have been found to possess significant anti-diabetic property after their preclinical and clinical evaluation. This present review presents the profiles of plants with hypoglycaemic properties reported in the earlier literatures. Use of these plants may delay the development of diabetic complications and can correct the metabolic abnormalities through variety of mechanisms. Moreover, during the past few years many phytoconstituents responsible for anti-diabetic effects have been isolated from plants. . Moreover, during the past few years some of the new bioactive drugs isolated from hypoglycaemic plants showed antidiabetic activity with more efficacy than oral hypoglycaemic agents used in clinical therapy.Keywords
Diabetes, Phytoconstituents, Plants, Natural Medicine.- Standardization and Preliminary Phytochemical Studies on the Bark of Madhuca indica J.F.G. Mel
Authors
1 Vels University, School of Pharmaceutical Sciences, Department of Pharmacognosy, Old Pallavaram, Chennai-116, IN
2 Vels University, School of Pharmaceutical Sciences, Department of Pharmacognosy, Old Pallavaram, Chennai-116, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 3, No 5 (2011), Pagination: 221-224Abstract
Madhuca indica J.F.G. mel belongs to the family "Sapotaceae". It is a much valued herbal medicine used for Rheumatism, Ulcers, itches, bleeding, spongy gums, tonsillitis and diabetes mellitus. The present study report its anatomical, microscopical, quantitative characters, powder microscopy, histochemical, fluorescence analysis, physiochemical standards, preliminary phytochemical standards and thin layer chromatography. The study revealed important diagnostic character which can be used for identification of the plant.
Keywords
Madhuca indica, Transverse Longitudinal Section, Radial Longitudinal Section.- Free Radical Scavenging Activity of Scindapsus officinalis Fruits
Authors
1 Dept. of Pharmacognosy, Vels College of Pharmacy, Pallavaram, Chennai-600 117, IN
2 Department of Pharmacognosy, Vels College of Pharmacy, Pallavaram, Chennai-600 117, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 4 (2010), Pagination: 280-283Abstract
In the present study, coarse powder of Scindapsus officinalis (Roxb.) Schott. fruit was extracted successively using hexane, chloroform, ethyl acetate and 50% ethanol. The ethyl acetate and 50% ethanolic extracts were investigated for its antioxidant activity by using nitric oxide and DPPH radical scavenging methods. The IC50 value was also calculated. Ascorbic acid was used as a standard. Both 50% ethanolic and ethyl acetate extract were found to exert concentration dependent free radical scavenging activity but former extract was more effective than the later on. The highest free radical scavenging activity by Scindapsus officinalis fruit extracts was observed at concentration of 1000 μg/ml.Keywords
Scindapsus officinalis (Roxb.) Schott., Antioxidant, Free Radicals, IC50 Value.- Antidepressant-Like Effects of the Ethanolic Extract of Albizzia lebbeck (Linn) Leaves in Animal Models of Depression
Authors
1 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai–117, Tamil Nadu, IN
2 Department of Pharmacognosy, Vels School of Pharmaceutical Sciences, Vels University, Pallavaram, Chennai-117, Tamil Nadu, IN
3 Department of Pharmacology, Sri Ramachandra College of Pharmacy, Sri Ramachandra University, Porur, Chennai-600116, Tamilnadu, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 2, No 1 (2010), Pagination: 30-33Abstract
The present study was designed to investigate the antidepressant effects of Albizzia lebbeck leaves in various animal depression models. The alcoholic extract (70% v/v ethanol) of Albizzia lebbeck leaves (200 and 400 mg/kg. p.o) was administered once daily for seven successive days to separate groups of young male swiss albino mice. The immobility periods of control and treated mice were recorded in two behavioral despair models forced swim test (FST), tail suspension test (TST) and the effect of extract on locomotor function of mice was studied using actophotometer. The antidepressant-like effect of tested drug was compared to that of imipramine (15 mg/kg. p.o) and fluoxetine (20mg/kg.p.o). The leaf extract at doses of 200 and 400 mg/kg significantly decreased the duration of immobility time in a dose dependent manner in both FST and TST.
The extract did not show significant effect on locomotor activity of mice. The efficacy of tested extract was found to be comparable to that of imipramine and fluoxetine. Our results suggested that the ethanolic extract of Albizzia lebbeck leaves exerts antidepressant-like effect.
Keywords
Albizzia lebbeck, Depression, Forced Swim Test, Tail Suspension Test.- Inhibitory Effect Terminalia chebula, Sida rhombifolia, Leucas cephalotes on Inflammatory Key Enzymes
Authors
1 Department of Pharmacognosy, School of Pharmaceutical Sciences, Vels University (VISTAS) Chennai, Tamilnadu, IN
2 NIPER, Kolkotta, IN