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Gupta, V.
- Phytochemical Evaluation of Extracts of Stem of Eclipta alba (Bhringaraja)
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Authors
Affiliations
1 Department of Chemistry, College of Pharmacy, IFTM, Moradabad, (U.P.), IN
2 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, (Rajasthan), 302025, IN
1 Department of Chemistry, College of Pharmacy, IFTM, Moradabad, (U.P.), IN
2 School of Pharmaceutical Sciences, Jaipur National University, Jagatpura, Jaipur, (Rajasthan), 302025, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 1, No 3 (2009), Pagination: 134-139Abstract
This paper deals with the detailed phytochemical evaluation of the stem of Eclipta alba (Bhringaraja) family: (Compositae). The preliminary phytochemical screening shows that different extracts of plant have different constituents like carbohydrate, alkaloids, phenolics, steroids, glycosides, fat and oils. TLC of the hexane extract after column extraction was shown Rf value 0.78 in Petroleum ether:Hexane:Chloroform:Methanol, used as mobile phase in 2:4:2:1 ratio and TLC of pet. Ether extract also shown Rf value is 0.72 in Petroleum ether:Hexane:Chloroform, used as mobile phase in 4:3:1 ratio after column extraction. This is evaluated by the instrumental analysis (UV, IR, and NMR) of hexane and pet. Ether extract. They shows consequently that pet. Ether extract contains alkane (2940 Cm-1, δ 0.827), alkene (1630 Cm-1, δ 1.253-1.351), monomer of aliphatic acid (1760 Cm-1 δ 2.169), aromatic amine (1570 Cm-1, δ 2.593) etc. and hexane extract contains alkane (2940 cm-1, δ 0.801-0.873) alkene (1625 Cm-1, δ 0.988-1.075) aldehyde (1740 Cm-1, δ 2.154 – 2.288) and aromatic alcohol (1110Cm-1, δ 5.324). These data suggests that the extracts (pet. ether and hexane) may have the glycoside, aliphatic acid, steroids, fats and oils. They are pharmacologically important.Keywords
Eclipta alba, Flavanoids, Glycosides, Thin Layer Chromatography.
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- Design and Antiinflamatory Activity of some Novel Oxadiazole Derivatives - An overview
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Authors
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 2, No 3 (2010), Pagination: 235-243Abstract
Oxadiazole derivates play vital role in biological field such as anti - microbial, anti - viral, anti - tubercular, anti - inflammatory and anti - convulsant activity. Therapeutic significance of these clinically useful drugs in treatment of inflammation encouraged the development of some more potent and significant compounds. oxadiazole derivatives are remarkably effective compounds for inflammation and analgesic activity. Extensive biochemical and pharmacological studie s have confirmed that these molecules are effective in inflammation. This comprehensive overview summarizes the chemistry of different derivatives of substituted oxadiazole along with their anti - inflammatory activity.Keywords
Oxadiazole Derivatives, Chemistry, Design, Anti - Inflammatory Activity.Full Text
- Solid Phase Synthesis and Their Screening System-Review
Abstract Views :265 |
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Authors
Affiliations
1 National Institute of Ayurvedic Pharmaceutical Research, CCRAS, Dept. of Ayush, Patiala, IN
2 National Botanical Research Institute, Rana Pratap Marg, Lucknow, IN
1 National Institute of Ayurvedic Pharmaceutical Research, CCRAS, Dept. of Ayush, Patiala, IN
2 National Botanical Research Institute, Rana Pratap Marg, Lucknow, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 3 (2011), Pagination: 362-369Abstract
The use of solid phase synthesis techniques has been explored as an alternative to conventional approaches for the synthesis of compounds used in the drug discovery process. Combinatorial chemistry now plays an important role in the lead discovery and hit optimization processes in the pharmaceutical world as well as in other areas of discovery chemistry. Now days this is an important technique for the development of different synthesis concepts that were intended to cover and explore the chemical space without having to prepare every individual compound. Solid phase synthesis technologies were developed in response to the increased screening capacities and target oriented lead finding. This article explains different linker, protecting group, cleavage methods used in solid phase synthesis, combinatorial libraries and screening system used in solid phase synthesis.
Keywords
Solid Phase Synthesis, Combinatorial Chemistry, Linker, Protecting Group.- Association of Circulating Resistin with Metabolic Risk Factors in Indian Females Having Metabolic Syndrome
Abstract Views :229 |
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Authors
Affiliations
1 Department of Physiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
2 Department of Obstetrics and Gynecology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
3 In Vitro Toxicology Laboratory, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, IN
1 Department of Physiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
2 Department of Obstetrics and Gynecology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, Uttar Pradesh, IN
3 In Vitro Toxicology Laboratory, Indian Institute of Toxicology Research, Lucknow, Uttar Pradesh, IN