Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Ezhilarasan, V.
- Simultaneous Estimation of Paracetamol and Zaltoprofen in Pharmaceutical Dosage Form by HPTLC
Abstract Views :196 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
1 Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Dayananda Sagar University, Bengaluru, IN
2 Lotus Labs, Vasanth Nagar, Bengaluru, IN
Source
Research Journal of Pharmacy and Technology, Vol 12, No 5 (2019), Pagination: 2075-2078Abstract
Objective: A method for HPTLC was developed and validated for simultaneous estimation of Paracetamol and Zaltoprofen in a pharmaceutical dosage form. Methods: The Chromatographic separation was achieved on TLC aluminum plates precoated with silica gel G60 F254 as the stationary phase. The mobile phase consisted of Hexane: Chloroform: Methanol in the ratio of 3.5:5.5:1v/v/v. Results: The method was found to be linear in the concentration range of 0.8-4μg/spot for PCM and 0.2-1 μg/spot for ZLT and the correlation coefficient were found to be 0.996 for PCM and 0.998 for ZLT. The %RSD value obtained for intraday precision were 0.237 and 0.377 and for inter-day precision were 0.259 and 0.766 respectively, the low % RSD indicates that proposed method is precise as per ICH guidelines. The accuracy of the method was determined and the mean recovery of PCM was 99.73-100.15% and ZLT was 99.57-100.18%. LOD and LOQ values were found to be 0.034 μg/spot and 0.105 μg/spot for PCM, 0.006μg/spot and 0.018 μg/spot for ZLT. Conclusion: The method reported is accurate, precise, specific, robust and linear for the estimation of Paracetamol and Zaltoprofen in Pharmaceutical dosage form.Keywords
Paracetamol, Zaltoprofen, HPTLC, Chromatography, HPTLC.
References
- Smita J Pawar et al., HPTLC estimation of Paracetamol, Diclofenac Sodium and Chlorzoxazone in Tablet dosage form. Asian J.Research Chem. 2009;2(3): 306-9.
- Sohan S Chitlange, Ranjana Soni, Sagar B Wankhede and Amol A Kulkarni, Spectrophotometric Methods for Simultaneous Estimation of Dexibuprofen and Paracetamol. Asian J.Research Chem. 2009;2(1): 30-33.
- Godse VP et al., Reverse phase HPLC method for determination of Aceclofenac and Paracetamol in tablet dosage form. Asian J.Research Chem. 2009;2(1): 37-40.
- Makoto MM, Ueda IH, NSAID zaltoprofen possesses novel antinociceptive mechanism through blockage of B2-type bradykinin receptor in nerve endings Neuro. Letters. 2006; 397: 249–253.
- International Conference on Harmonization, Q2 (R1), Harmonized tripartite guidelines, Validation of analytical procedures: text and methodology, Geneva, November 2005.
- Karbhari PA, Joshi SJ, Bhoir SI. RP-LC gradient elution method for simultaneous determination of related substances of Zaltoprofen and Paracetamol and application for drug excipient compatibility study. International Journal of Pharmaceutical Sciences and Research. 2014;6:698-703.
- Archana Ambekar. Validated stability-indicating HPTLC method for simultaneousestimation of Paracetamol and Aceclofenac and their impurities. J Chromatogr SepTech 2016;7:324.
- Deepa Moye Shrestha, Srinivasa Rao T, Sreedhar C, Akkamma HG, Bharadwaja Reddy G, Purushotam Kumar Yadav. Development and validation of analytical method for the simultaneous estimation of Naproxen and Esomeprazole in bulk and pharmaceutical formulation. Bull Pharm Res. 2016;6(1):28-35.
- Dias L, Mallya R, Patani K. Development and validation of new RP-HPLC methodfor estimation of Mephenesin and Ibuprofen. Int J Pharm Sci. Res.2016;7(12):4971-77.
- Manisha S. Phoujdar, Ritesh T. Kucheriya, Shwetal Vassa P.Effect of pH on RP-HPLCmethod development and validation of Ibuprofen in bulk and tablet dosage form. World Journal of Pharmacy and Pharmaceutical Sciences. 2016;5(7):1946-56.
- Abburu Sreedhara Rao, Punna Rao, Mutyala Krishnaji Rao, Anima S Dadhich. Development and validation of RP-HPLC method for assay of Acetylsalicylic acid informulations. European Journal of Biomedical and Pharmaceutical Sciences. 2016;3(5):348-353.Kumaraswamy Gandla, Harika T, Lalitha R. Development and Validation of RP-HPLC Method for Simultaneous Estimation of Aceclofenac and Tramadol in Tablet Dosage Form. Asian J Res Pharm Sci. 2015;5(3):135-138.
- Haritha Gali, Vishwanadham Yerragunta. Development and validation of RP-HPLC method for simultaneous estimation of Naproxen and Esomeprazole in Pharmaceutical dosage form. Journal of Innovations in Pharmaceutical and Biological Sciences. 2016;3(3):39-42.