Refine your search
Collections
Co-Authors
Journals
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Balamuralidhara, V.
- Evolution of Pharmacy in Karnataka:A Bird View
Abstract Views :222 |
PDF Views:128
Authors
Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagara, Mysore – 570015, Karnataka, IN
1 Department of Pharmaceutics, JSS College of Pharmacy, JSS University, Sri Shivarathreeshwara Nagara, Mysore – 570015, Karnataka, IN
Source
Asian Journal of Pharmaceutical Research and Health Care, Vol 10, No 3 (2018), Pagination: 84-88Abstract
In India, Pharmacy profession ensures the quality drugs are made available at affordable prices to the people. Drugs Regulation in India is implemented under the provisions of formerly called The Drugs Act, 1940 and Rules 1945 until the Drugs and Cosmetics Act, 1940 came to existence and Regulatory reforms efforts in country initiated with Mashelakar Committee observation. Karnataka has been one of the pioneer States in India with an exemplary track record. With its rich tradition and ethical values embedded in the pharmacy profession, the important milestones recorded depict the history and development of pharmacy profession and educational activity in Karnataka. It has a strong base of educational institutions imparting courses in Pharmacy and some of the institutions have international repute to its credit. Karnataka is one of the fastest growing states in the Country and nearly 268 pharmaceutical and biotech companies are housed in the State. Karnataka is a vibrant pharmaceutical manufacturing hub fortified with sound knowledge based institutions and skilled human resource available in the state; it provides innovative, quality and affordable health care solution to masses. In this short review author provides some of the glimpses of the pharmacy profession in Karnataka.Keywords
Drug, Education, Health, Karnataka, Regulation.Full Text
References
- National Health Policy; 2015. Available from: www.moh.fw.nic.in
- Singh H, Prakashan V. History of Pharmacy in India Pharmacy Practice; 2002. p. 226. Available from: www.iisc.ernet.in/currsci/jul252002/171
- History of Pharmacy. Available from: www.kar.nic.in
- A brief note on Drugs Control Department Karnataka. Available from: www.kar.nic.in
- A brief history of CDSCO. Available from: www.cdsco.nic.in
- Ladkat SR, Khodade RK, Chaudhari P, Kasture PV. The Indian pharmaceutical industry: Evolution of regulatory system and present scenario. International Research Journal of Pharmacy. 2012; 3(6). Available from: www.irjponline.com
- Information on Karnataka state pharmacy council. Available from: www.kspc.nic.in
- Rivastigmine Tartrate Solid Lipid Nanoparticles Loaded Transdermal Film:An In vivo Study
Abstract Views :163 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagar, Mysuru-570015, Karnataka, IN
1 Department of Pharmaceutics, JSS College of Pharmacy, JSS Academy of Higher Education and Research, JSS Medical Institutions Campus, Sri Shivarathreeshwara Nagar, Mysuru-570015, Karnataka, IN
Source
Research Journal of Pharmacy and Technology, Vol 11, No 1 (2018), Pagination: 227-230Abstract
In the present investigation, Rivastigmine Tartrate incorporated solid lipid nanoparticles (SLN) films were made to enhance its uptake to brain via systemic circulation. SLN were prepared by modified emulsification diffusion method and SLN’s loaded transdermal films were prepared by solvent casting method. The optimized Rivastigmine Tartrate SLN loaded formulation was evaluated for pharmacokinetic study and dermal toxicity study. In vivo studies were performed on New Zealand white rabbits and various pharmacokinetic and dermal toxicity parameters were determined. The pharmacokinetic parameters after administration of Rivastigmine Tartrate loaded SLN film were found to be, Tmax 3 h, Cmax 116.17 ± 1.5 ng/mL, AUC0 - ∞ 1848.29±4.87 ng.h/mL, and Ke 0.18 ± 0.028 h-1. The dermal toxicity study was carried out for 3 min, 1 h and 4 h respectively with optimized film and no skin irritation or redness was found. The results highlights that the prepared formulation of SLN loaded films were able to deliver a sustained supply of the Rivastigmine Tartrate.Keywords
Rivastigmine Tartrate, SLN, Pharmacokinetic Study.
References
- Farlow M, Anand R, Messina Jr J, Hartman R, Veach J. A 52-week study of the efficacy of Rivastigmine in patients with mild to moderately severe Alzheimer's disease. European Neurology. 2000; 44(4): 236-241.
- Nozaki S, Yamaguchi M, Lefèvre G. Pharmacokinetic Modeling to Simulate the Concentration-Time Profiles After Dermal Application of Rivastigmine Patch. 2016; 105(7): 2213-2221.
- Karaman Y, Erdogan F, Koseoglu E, Turan T, Ersoy AO. A 12-month study of the efficacy of rivastigmine in patients with advanced moderate Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 2005; 19(1): 51-56.
- Emre M, Aarsland D, Albanese A, et al. Rivastigmine for dementia associated with Parkinson's disease. The New England Journal of Medicine. 2004; 351(24): 2509-2518.
- Onor ML, Trevisiol M, Aguglia E. Rivastigmine in the treatment of Alzheimer's disease: an update. Clinical Interventions in Aging. 2007; 2(1): 17-32.
- Finkel SI. Effects of rivastigmine on behavioral and psychological symptoms of dementia in Alzheimer's disease. Clinical Therapeutics. 2004; 26(7): 980-990.
- Farlow MR, Cummings JL, Olin JT, Meng X. Effects of oral rivastigmine on cognitive domains in mild-to-moderate Alzheimer's disease. American Journal of Alzheimer's Disease and Other Dementiasr. 2010; 25(4): 347-352.
- Burns A, Spiegel R, Quarg P. Efficacy of rivastigmine in subjects with moderately severe Alzheimer's disease. International Journal of Geriatric Psychiatry. 2004; 19(3): 243-249.
- Narasimha MS, Shivakumar HN. Chapter 1Topical and transdermal drug delivery. In: Vitthal SK, ed. Handbook of Non-invasive Drug Delivery Systems. Boston: William Andrew Publishing; 2010; pp. 1-36.
- Amnuaikit C, Ikeuchi I, Ogawara K, Higaki K, Kimura T. Skin permeation of propranolol from polymeric film containing terpene enhancers for transdermal use. International Journal of Pharmaceutics. 2005; 1(2): 167-178.
- Aqil M, Ali A. Monolithic matrix type transdermal drug delivery systems of pinacidil monohydrate: in vitro characterisation. European Journal of Pharmaceutics and Biopharmaceutics. 2002; 2: 161-164.
- Reddy MB, McCarley KD, Bunge AL. Physiologically relevant one-compartment pharmacokinetic models for skin. 2. Comparison of models when combined with a systemic pharmacokinetic model. Journal of Pharmaceutical Sciences 1998; 87(4): 482-490.
- Brown HS, Hattis D. The role of skin absorption as a route of exposure to volatile organic-compounds in household tap water: A simulated kinetic approach. Journal of the American College of Toxicology. 1989; 8(5): 839-851.
- Shatkin JA, Brown HS. Pharmacokinetics of the dermal route of exposure to volatile organic chemicals in water: a computer simulation model. Environmental Research. 1991; 56(1): 90-108.
- McCarley KD, Bunge AL. Pharmacokinetic models of dermal absorption. Journal of Pharmaceutical Sciences. 2001; 90(11): 1699-1719.
- Polak S, Ghobadi C, Mishra H, et al. Prediction of concentration-time profile and its inter-individual variability following the dermal drug absorption. Journal of Pharmaceutical Sciences. 2012; 101(7): 2584-2595.
- OECD (2015) OECD Guideline for testing of chemicals, Acute Dermal Irritation/Corrosion, 404, 28 July 2015.
- Zouhir D, Hdria D, Riachi F, Serakta M, Chettou A, Maameri Z. Irritantcy potential and sub acute dermal toxicity study of pistacia lentiscus fatty oil as a topical traditional remedy. African Journal of Traditional, Complementary and Alternative Medicines. 2013; 10(3): 480-489.
- Kapil R, Dhawan S, Sarwar B, Bhupinder S. Buccoadhesive films for once-a-day administration of rivastigmine: systemic formulation development and pharmacokinetic evaluation. Drug Development and Industrial Pharmacy. 2013; 39(3): 466-480.
- Kale MN. Development of validated RP-HPLC method for quantitative estimation of Rivastigmine hydrogen tartrate in transdermal drug delivery system. International Journal of Pharmaceutical Sciences and Research. 2004; 5(5): 1892-1902.