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Bairagi, V. A.
- Antioxidants Therapy in Cognitive Dysfunction Associated with Diabetes Mellitus: An Overview
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Authors
Affiliations
1 K.B.H.S.S.T's Institute of Pharmacy, Bhayagaon Road, Malegaon Camp, Malegaon, Dist. Nasik (MS), IN
1 K.B.H.S.S.T's Institute of Pharmacy, Bhayagaon Road, Malegaon Camp, Malegaon, Dist. Nasik (MS), IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 3, No 2 (2011), Pagination: 39-44Abstract
Diabetic complications, characterized by endothelial dysfunction. There is growing evidence that excess generation of highly reactive free radicals, largely due to hyperglycemia, causes oxidative stress. Overproduction free radicals result in vascular dysfunction, damage to cellular proteins, membrane lipids and nucleic acids. As our understanding of the mechanisms of free radical generation evolves, it is becoming clear that rather than merely scavenging reactive radicals, a more comprehensive approach aimed at preventing the generation of these reactive species as well as scavenging may prove more beneficial. Endogenous antioxidant defenses are both non-enzymatic (e.g., uric acid, glutathione, bilirubin, thiols, albumin, and nutritional factors, including vitamins and phenols) and enzymatic (e.g., the superoxide dismutase's, the glutathione peroxides [GSHPx], and catalyses). So that there is use of antioxidants must be used for future beneficial. Therefore, new strategies with classic as well as new antioxidants should be implemented, to prevent cognitive dysfunction associated with diabetes mellitus.Keywords
Diabetes Mellitus, Free Radical, Hyperglycemia, Antioxidants.
References
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- Isolation and Characterizations of Phytoconstituents from Quisqualis indica Linn. (Combretaceae)
Abstract Views :223 |
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Authors
Affiliations
1 Padmavati College of Pharmacy, Periyanahalli, Dharmapuri -635205, IN
2 KBHSS Trust’s Institute of Pharmacy, Bhaygaon Road, Malegaon-423105, Dist- Nasik, Maharashtra, IN
1 Padmavati College of Pharmacy, Periyanahalli, Dharmapuri -635205, IN
2 KBHSS Trust’s Institute of Pharmacy, Bhaygaon Road, Malegaon-423105, Dist- Nasik, Maharashtra, IN
Source
Research Journal of Pharmacognosy and Phytochemistry, Vol 4, No 4 (2012), Pagination: 229-233Abstract
Objectives: To isolate the phytoconstituents by column chromatography and characterization of phytoconstituents by using spectroscopic technique.
Methods: The petroleum ether extract of leaves and flower of Quisqualis indica were studied for isolation of triterpenoids and methanolic extract for flavonoids and tannins by column chromatography and preparative-thin layer chromatography (P-TLC) and characterized by spectroscopic techniques (UV-visible spectroscopy, infrared spectroscopy, 1H and 13C NMR spectroscopy and mass spectrometry).
Results: The Tannins (Gallic acid), flavonoid (Quercetin and Rutin) and Terpenoids (β-sitosterol and Lupeol) were isolated from leaves and flowers of Quisqualis indica and identified with help of preliminary phytochemical methods, physical properties, spectroscopic data and Co-TLC with authentic standards.
Conclusion: The isolation and characterization of compound A, B from petroleum extract and Compound C, D, E from methanolic extract of leaves and flower were the first ever to be reported from this plant the work was carried by means of various physical and spectral techniques.