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Santosh, Undare
- Spectrophotometric Method Development and Validation of Prazosin
Abstract Views :191 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal-Baramati, Dist-Pune, Maharashtra 413115, IN
2 PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra 431112, IN
1 Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal-Baramati, Dist-Pune, Maharashtra 413115, IN
2 PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra 431112, IN
Source
Research Journal of Science and Technology, Vol 8, No 1 (2016), Pagination: 1-4Abstract
Prazosin Hydrochloride (PRZ) is an antihypertensive agent which is one of the leading marketed drugs in the world. A rapid, specific and economic UV spectrophotometrically method has been developed using methanol as a solvent to determine the PRZ content in bulk and pharmaceutical dosage formulations. At a pre-determined Λmax of 2 nm, it was proved linear in the range of 1 - 5 μg/mL, and exhibited good correlation coefficient (R2=0.999) and excellent mean recovery. This method was successfully applied to the determination of PRZ content in one marketed brand from India and the results were in good agreement with the label claim. The method was validated statistically and by recovery studies for linearity, precision, accuracy, ruggedness, robustness, LOD and LOQ. The obtained results proved that this method can be employed for the routine analysis of PRZ in bulks as well as in the commercial formulations.Keywords
UV-Spectrophotometer, Prazosin, Antihypertensive Agent.- Estimation of Venlafaxine in Commercial Dosage Forms Using Simple and Convenient Spectrophotometric Method
Abstract Views :187 |
PDF Views:2
Authors
Affiliations
1 Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra-413115, IN
2 PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra-431112, IN
1 Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra-413115, IN
2 PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra-431112, IN
Source
Asian Journal of Pharmaceutical Analysis, Vol 5, No 3 (2015), Pagination: 142-146Abstract
Venlafaxine belongs to a group of Antidepressant with a novel chemical structure. In these studies describes a simple, accurate, precise and cost effective UV-visible spectrophotometric method for the estimation of Venlafaxine hydrochloride in bulk and pharmaceutical formulations. The method is based on the measurement of absorbance of Venlafaxine hydrochloride solution in 0.1N NaOH at 225 nm. The method obeys Beer's Lambert's law in the selected concentration range 5-25 μg/ml in selected solvent. The slope, intercept and correlation coefficient were also calculated. Results of percentage recovery study shows that the method was not affected by the presence of common excipients in tablets. The parameters like linearity, precision, accuracy were studied according to International Conference on Harmonization (ICH) guidelines. The developed method was validated in terms of accuracy, precision, linearity, limit of detection and limit of quantitation which proves suitability of proposed method for routine estimation of venlafaxine hydrochloride in bulk and pharmaceutical formulations.Keywords
UV-Visible Spectrophotometer, Method Development, Venlafaxine Hydrochloride.- Ultraviolet Spectrophotometric Method for Determination of Glipizide in Bulk and Tablet Dosage Formulation
Abstract Views :221 |
PDF Views:0
Authors
Affiliations
1 Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra-413115, IN
2 PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra- 431112, IN
1 Department of Pharmaceutical Analysis, Shivnagar Vidya Prasarak Mandal’s College of Pharmacy, Malegaon (Bk), Tal- Baramati, Dist- Pune, Maharashtra-413115, IN
2 PG Department of Chemistry, Marathwada Shikshan Prasarak Mandal’s Balbhim Arts, Science and Commerce College, Beed, Maharashtra- 431112, IN