Refine your search
Collections
Co-Authors
Year
A B C D E F G H I J K L M N O P Q R S T U V W X Y Z All
Rachmaningayu, Ulyasari
- Topical Application of Citrus limon Peel Essential Oil Increased Pro-Inflammatory Cytokines Expression on Type IV Hypersensitivity Reaction
Abstract Views :137 |
PDF Views:76
Authors
Fatma Yasmin Mahdani
1,
Ulyasari Rachmaningayu
2,
Elva Anjani
2,
Asri Dewanti Adhi Nugrahaeni
2,
Naqiya Ayunnisa
3,
Salsabila Fitriana Putri
3,
Meircurius Dwi Condro Surboyo
1,
Nurina Febriyanti Ayuningtyas
1,
Priyo Hadi
1,
Hening Tuti Hendarti
1,
Diah Savitri Ernawati
1
Affiliations
1 Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
2 Dental Profession Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
3 Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
1 Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
2 Dental Profession Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
3 Bachelor Dental Science Program, Faculty of Dental Medicine, Universitas Airlangga, Surabaya - 60132, ID
Source
International Journal of Medical and Dental Sciences, Vol 12, No 1 (2023), Pagination: 2063-2070Abstract
Introduction: Citrus limon peels essential oil has the potential to be developed as a topical medicine due to its active components. The essential oil has been demonstrated in numerous studies to have anti-inflammatory, anti-microbial, antifungal, and antioxidant properties. A study is required to determine whether Citrus limon peel essential oil can cause a type IV hypersensitivity reaction by examining the expression of the cytokines TNF-, IL-1, and IL-6 as well as the clinical manifestations on an animal skin. In this study, the effect of topically applying the essential oil of Citrus limon peel on the expression of TNF-α, IL-1, and IL-6 as well as on type IV hypersensitivity reaction symptoms was examined. Methods: This study is based on the guinea-pig maximisation test method in NADFC RI Regulation Number 7 of 2014, with two groups (control group and treatment group) for each set of ten samples. Citrus limon peels essential oil was administered to the treatment group, whereas CMC-Na was given to the control group. Animal models were euthanized after which the tissues were prepared as specimens for immunohistochemical staining. The expression of cytokines was computed and examined using a light microscope. Results: There were no clinical signs of type IV hypersensitivity in either group, and the expression of TNF-α, IL-1 and IL-6 in the treatment group was found higher than in the control group. Conclusion: After topical administration of Citrus limon peels essential oil, there was an increase in the expression of TNF-α, IL-1 and IL-6 without any clinical symptoms of type IV hypersensitivity.Keywords
Citrus limon, Essential Oil, IL-6, TNF-α, IL-1, Type IV HypersensitivityFull Text
References
- Kumar G, Jalaluddin Md, Rout P, Mohanty R, Dileep CL. Emerging trends of herbal care in dentistry. Journal of Clinical and Diagnostic Research. 2013; 7(8):1827-9.
- Bustanussalam. Pemanfaataan obat tradisional (herbal) sebagai obat alternatif. BioTrends. 2016; 7(1):20-5.
- Turner T, Burri B. Potential nutritional benefits of current citrus consumption. Agriculture. 2013; 3(1):170-87. https:// doi.org/10.3390/agriculture3010170
- Kostner L, Anzengruber F, Guillod C, Recher M, Grendelmeier PS, Navarini AA. Allergic contact dermatitis. Immunology and Allergy Clinics of North America. 2017; 37(1): 141-52. https://doi.org/10.1016/j.iac.2016.08.014 PMid:27886903
- Dev C, Nidhi SSRR. Basketful benefit of Citrus limon. International Research Journal of Pharmacy. 2016; 7(6):1- 4. https://doi.org/10.7897/2230-8407.07653
- Jain N, Sharma M. Evaluation of citrus lemon essential oil for its chemical and biological properties against fungi causing dermatophytic infection in human beings. Analytical Chemistry Letters. 2017; 7928:402-9. https://doi.org/10.10 80/22297928.2017.1349620
- Mahdani FY, Ernawati DS, Hadi P, Soebadi B, Mardiyana SD, Susanti D, et al. Citrus limon L. gel stimulate lymphocytes and interleukin-10 expression in traumatic diabetic oral ulcers. Phcog Res. 2020; 12:299-302.
- Ben HA, Ben HN, Smaoui S, Hamdi N. Citrus lemon essential oil: Chemical composition, antioxidant and antimicrobial activities with its preservative effect against Listeria monocytogenes inoculated in minced beef meat. Lipids Health Dis. 2017; 16(1):1-11. https://doi.org/10.1186/ s12944-017-0487-5 PMid:28774297 PMCid:PMC5543433
- Steventhie L, Parmadianti AE, Ayuningtyas NF. Efektivitas minyak esensial kulit buah jeruk lemon (Citrus limon) Terhadap pertumbuhan jamur candida tropicalis secara invitro (in vitro, effectivity of lemon peel essential oil (Citrus limon) against candida tropicalis). Oral Med Dent J. 2016; 8(2):25- 30.
- Syarifah IM, Ernawati DS, Hernawan I. Efektivitas pemberian minyak esensial kulit buah Citrus limon l. 0,78% topikal terhadap peningkatan jumlah makrofag pada penyembuhan ulkus traumatikus tikus wistar diabetik. Skripsi Fak Kedokt Gigi Univ Airlangga. 2017.
- Coico R, Sunshine G. Immunology: A short course. 7th ed. Chichester: John Wiley & Sons, Ltd.; 2015. p. 3-4, 97-105.
- Actor JK, Ampel NM. Hypersensitivity: T Lymphocytemediated (Type IV). Encyclopedia of Life Sciences; 2009. p. 3-4, 97-105.
- Bakula A, Lugović-Mihić L, Situm M, Turcin J, Sinković A, Lugovic Mihic L, Sinkovic A. Contact allergy in the mouth: Diversity of clinical presentations and diagnosis of common allergens relevant to dental practice. Acta Clinica Croatica. 2011; 50(4): 553-61.
- Buttaravoli P, Hudson P. Part 11 dermatologic emergencies in minor emergencies. 2012. p. 639 https://doi.org/10.1016/ B978-0-323-07909-9.00160-4
- Popovic J, Cvetkovic T, Dzopalic T, et al. The concentration of tumor necrosis factor alpha in periapical lesions. Stomatol Glas Srb. 2014; 61(1):7-13. https://doi. org/10.2298/SGS1401007P
- Mahdani FY, Parmadiati AE, Ernawati DS, Husain H, Ekaperdana SAP, Rachmaningayu U, Hadi P, Hendarti HT, Surboyo MDC. Citrus limon peel essential oil-induced Type IV hypersensitivity reaction. J Exp Pharmacol. 2020; 12:213- 20. https://doi.org/10.2147/JEP.S256139 PMid:32801948 PMCid:PMC7394596
- Wong Y, Ahmad-Mudzaqqir M, Wan Nurdiyana W. Extraction of essential oil from cinnamon (Cinnamomum zeylanicum). Orient J Chem. 2014; 30(1):37-47. https://doi.org/10.13005/ojc/300105 18. Sharma B, Singh LR, Pradesh U, Pradesh U. Pharmaceutical gels for topical drug delivery: An overview. Int J Res Pharm Pharm Sci. 2018; 3(2):19-24.
- Tjahyono, N, Parmadiati, AE, Mahdani, FY. Uji sitotoksisitas minyak esensial kulit jeruk lemon (Citrus Limon) terhadap sel human gingival fibroblas. Oral Medicine Dental Journal. 2017; 9(1):53-60.
- Dhifi W, Bellili S, Jazi S, Bahloul N, Mnif W. Essential oils chemical characterization and investigation of some biological activities: A critical review. Medicines. 2016; 3(4):25. https://doi.org/10.3390/medicines3040025 PMid:28930135 PMCid:PMC5456241
- Jongedijk E, Cankar K, Buchhaupt M, Schrader J, Bouwmeester H, Beekwilder J. Biotechnological production of limonene in microorganisms. Applied Microbiology and Biotechnology. 2016; 100(7):2927- 38. https://doi.org/10.1007/s00253-016-7337-7 PMid:26915992 PMCid:PMC4786606
- Siddique AB, Rahman SMM, Hossain MA. Chemical composition of essential oil by different extraction methods and fatty acid analysis of the leaves of Stevia Rebaudiana Bertoni. Arabian Journal of Chemistry. King Saud University. 2016; 9:S1185-9. https://doi.org/10.1016/j.arabjc.2012.01.004
- Liu H. Comprehensive natural products II: Chemistry and Biology. 1st ed. United Kingdom: Elsevier Ltd; 2010.
- Silveira E Sá RDCD, Andrade LN, De Sousa DP. A review on anti inflammatory activity of monoterpenes. Molecules. 2013; 18(1):1227-54. https://doi.org/10.3390/molecules18011227 PMid:23334570 PMCid:PMC6269770 25. Shahbazi S, Bolhassani A. Immunostimulants : Types and functions. J Med Microbiol Infec Dis. 2017; 4(69):45-51.
- Audrain H, Kenward C, Lovell CR, Green C, Ormerod AD, Sansom J, Chowdhury MMU, Cooper SM, Johnston GA, Wilkinson M, King C, Stone N, Horne HL, Holden CR, Wakelin S, Buckley DA. Allergy to oxidized limonene and linalool is frequent in the UK. The British Journal of Dermatology. 2014; 171(2):292-7. https://doi.org/10.1111/ bjd.13037 PMid:24702129
- Oliver B, Krishnan S, Rengifo Pardo M, Ehrlich A. Cosmeceutical contact dermatitis-cautions to herbals. Current Treatment Options in Allergy. 2015; 2(4):307-21. https://doi.org/10.1007/s40521-015-0066-9
- Christensson JB, Karlberg AT, Andersen KE, Bruze M, Johansen JD, Garcia-Bravo B, White IR. Oxidized limonene and oxidized linalool- Concomitant contact allergy to common fragrance terpenes. Contact Dermatitis. 2016; 74(5):273-80. https://doi.org/10.1111/cod.12545 PMid:26918793
- Raffalli C, Clouet E, Kuresepi S, Damiens MH, Lepoittevin JP, Pallardy M, Kerdine- Römer S. Fragrance allergens linalool and limonene allylic hydroperoxides in skin allergy: Mechanisms of action focusing on transcription factor Nrf2. Toxicological Sciences. 2017; 1-10. https://doi. org/10.1093/toxsci/kfx207 PMid:29029310 30. Sudiono J. Sistem Kekebalan Tubuh. Jakarta: EGC; 2014.
- Abbas AK, Lichtman AH, Pillai S. Basic immunology: Functions and disorders. 5th ed. Missouri: Elsevier; 2016. p. 232-3, 243-4.
- Giamarellos-Bourboulis EJ, Raftogiannis M. The immune response to severe bacterial infections: Consequences for therapy. Expert Rev Anti Infect Ther. 2012; 10(3):369-80. https://doi.org/10.1586/eri.12.2 PMid:22397569
- Murphy K. Janeway’s Immunobiology. 8th ed. New York: Garland Science, Taylor & Francis Group; 2012. p. 571, 588- 9, 600-3.
- Subowo. Imunologi Klinik. Edisi Ke-2. Jakarta: Sagung Seto; 2013.
- Abbas AK, Lichtman AH, Pillai S. Cellular and molecular immunology. 8th ed. Philadelphia: Elsevier Saunders; 2015. p. 216-21, 400, 405-9.
- Astuti DP. Formulasi dan Uji Stabilitas Fisik Sediaan Gel Antiseptik Tangan Minyak Atsiri Bunga Lavender (Lavandula angustifolia Miller). Jurnal Farmaka. 2017; 15(1):176- 84.
- Marques-Marinho FD, Vianna Soares CD. Establishment of Artificial Human Sera (ARTHUS) based on chimeras of Fcgamma RI and human immunoglobulin domains. Allergy: European Journal of Allergy and Clinical Immunology. 2013; 141-62.
- Maulina L, Sugihartini N. Formulasi gel ekstrak etanol kulit buah manggis (Garcinia mangostana L.) dengan variasi gelling agent sebagai sediaan luka bakar. Pharmaciana. 2015; 5:43-52. https://doi.org/10.12928/pharmaciana. v5i1.2285
- Johansen JD. Fragrance contact allergy: A clinical review. American Journal of Clinical Dermatology. 2003; 4(11):789- 98. https://doi.org/10.2165/00128071-200304110-00006 PMid:14572300
- Nath NS, Liu B, Green C, Atwater AR. Contact allergy to hydroperoxides of linalool and D-Limonene in a US population. Am Contact Dermat Soc. 2017; 28(5):313-6. https:// doi.org/10.1097/DER.0000000000000318 PMid:28885310