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Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Dr. B.C Roy College of Pharmacy and Allied Health Sciences, Meghnath Shah Sarani, Bidhan Nagar, Durgapur-6, West Bengal, IN
2 College of Pharmaceutical Sciences, Mohuda, IN
Source
Asian Journal of Research in Chemistry, Vol 2, No 3 (2009), Pagination: 297-299
Abstract
A rapid and sensitive reverse phase HPLC method is depicted for the qualitative and quantitative assay of Etoricoxib in pharmaceutical dosage forms. Etoricoxib was chromatographed on a reverse phase C18 column with a mobile phase consisting of methanol:phosphate buffer (pH-7.8) in the ratio of 90:10 v/v. The mobile phase was pumped at a flow rate of 1 ml/min. Mirtazapine was used as an internal standard and the eluents were monitored at 235 nm. The retention time of the drug was 3.428 min. With this method, linearity is observed between area under curve (AUC, expressed in mV.min) and concentration of Etoricoxib in the injected solution, in the range of 10-200 μg/ml. The method was found to be applicable for analysis of drug in tablets. The results of the analysis were validated statistically.
Keywords
Etoricoxib, Reverse Phase HPLC, Tablets.
