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K. Kavitha ¹, K. Bindu Sree ², P. Jaya Preethi ², K. Pavan Kumar ², R. Rajvel ², T. Sivakumar ²

Affiliations
1 Department of Pharmaceutical Chemistry, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, Tamil Nadu, IN
2 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Erode, Tamil Nadu, IN

Abstract

The coumarin-3-carboxylate prepared by known Knovengeal condensation. The coumarin-3-carbohydrazide prepared by reaction between formed carboxylate derivative with Hydrazine hydrate. The condensation of coumarin-3-carbohydrazide (CD-3) with phenylisothiocynate gives coumarin-3-carbo-N-phenylthiosemicarbazide (CD-4). The cyclization of CD-4 under different reaction conditions gives 1, 3, 4-oxadiazole, 1,3,4- thiadiazole, 1,2,4-triazole, thiazolidinone and thiopyrimidone. The synthesized compounds were charectarized by spectral analysis (IR, 1HNMR, Mass). All the compounds were screened for their Antiinflammatory, Analgesic and Antituberculosis activity. The disc diffusion method was used for Antituberculosis activity. The MIC was determined by the micro broth dilution method using Mueller-Hinton broth. The Analgesic activity was performed by Acetic acid induced method. The Antiinflammatory activity was performed by Carrageenan induced paw edema method.

Keywords

Knovengeal Condensation, Phenylisothiocynate, Characterization, Anti Tuberculosis Activity.

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S. Haja Sherief ¹, S. Sindhura ², S. Anusha ², P. Jaya Preethi ², S. Sengotuvelu ², T. Sivakumar ²

Affiliations
1 Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, Tamil Nadu, IN
2 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode, Tamil Nadu, 638052, IN

Abstract

The present paper deals with evaluation of anti-anxiety activity of extract of Cyndon dactylon linn (200mg/kg and 400mg/kg P.O) on male mice using various paradigms of anxiety Cynodon dactylon commonly known as Durva is considered as a sacred herb by the Hindus and is used in religious rites. It is widely used by the people of India as a traditional medicine for diarrhea, dysentery, catarrhal opthalmia, dropsy, etc. Despite a long tradition of use, systematic phytochemical and pharmacological work has been carried out on this potential plant. Extraction was carried out with soxhlet apparatus using different solvent. Phytochemical screening showed presence alkaloids, tannins, carbohydrates, fixed oils, glycosides, flavanoids in methanolic extract of Cyndon dactylon linn thus, these constituents might be responsible for anxiolytic potential and was subjected to preliminary anti-anxiety screening studies, with a view to ascertain the verity of its traditional use as an anxiolytic.. The anti-anxiety activity was done by using elevated plus maze test, open field test, rotarod test, despair swim test, locomotar activity in rats,and then compared with the standard drug and control. In elevated plus maze, extract ( 200mg/kg and 400mg/kg) had shown a dosedependent increase in time spent and number of entries into open arm compared to control group. The number of central squares, peripheral squares crossed and rearings were stepped up significantly in open field paradigm. The treated groups had shown accession in time spent in light compartment, number of crossings, latency compared to control group in light dark exploration test.The alcoholic extract of Cyndon dactylon possesses significant facilitation of anti-anxiety without affecting motor coordination.

Keywords

Cyndon dactylon (Linn), Phytochemical Screening, Anti-Anxiety Activity.

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T. Sivakumar ¹, G. Chithira Rakshmi ¹, A. Ummu Salma ¹

Affiliations
1 Department of Information Technology, PSG College of Technology, IN

Abstract

AADHAR is an Indian Government Project to provide unique identification to each Citizen of India. The objective of the project is to collect all the personal details and the biometric traits from each individual. Biometric traits such as iris, face and fingerprint are being collected for authentication. All the information will be stored in a centralized data repository. Considering about the storage requirement for the biometric data of the entire population of India, approximately 20,218 TB of storage space will be required. Since 10 fingerprint data are stored, fingerprint details will take most of the space. In this paper, the storage requirement for the biometric data in the AADHAR project is analyzed and a method is proposed to reduce the storage by cropping the original biometric image before storing. This method can reduce the storage space of the biometric data drastically. All the measurements given in this paper are approximate only.

Keywords

Biometrics, Image Processing, Image Storage.

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Bindu Sree Koduru ¹, Akshay R. Shinde ¹, P. Jaya Preeti ¹, K. Pavan Kumar ¹, R. Rajavel ¹, T. Sivakumar ¹

Affiliations
1 Department of Chemistry, Nandha College of Pharmacy and Research Institute, Erode-638052, Tamil Nadu, IN

Abstract

The compounds of different Pyrazoline derivatives were synthesized by cyclization of substituted chalcone derivatives in presence of hydrazine hydrate (a-e). All the synthesized compounds were characterized by spectral analysis (IR, MS and NMR). The REMA (Resazurin Microtiter Assay) plate method was used for anti-tuberculosis activity. The minimum inhibitory concentration (MIC) of the newly synthesized compound was tested against Mycobacterium tuberculosis H₃₇R_V. The Analgesic activity was performed by Acetic acid induced method. The Anti-inflammatory activity was performed by Carrageenan induced paw edema method.

Keywords

Chalcone, Hydrazine Hydrate, Pyrazoline Derivatives, Characterization, Anti-Tuberculosis Activity.

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M. Vijayabaskaran ¹, G. Babu ¹, N. Venkateswaramurthy ¹, P. Sivakumar ¹, P. Perumal ¹, T. Sivakumar ², R. Sambathkumar ³, B. Jayakar ⁴

Affiliations
1 JKK Nataraja College of Pharmacy, Komarapalayam, Namakkal District, Tamil Nadu 638183, IN
2 Nandha College of Pharmacy, Erode, Tamil Nadu 638 052, IN
3 Department of Pharmaceutics, Seventh of April University, Al-Zawia City, LY
4 Vinayaka Missions College of Pharmacy, Salem, Tamil Nadu, IN

Abstract

The study was aimed at evaluating the antitumor and antioxidant activities of ethanol extract of Pseudarthria viscida (Family: Fabaceae) against Ehrlich ascites carcinoma (EAC)-bearing Swiss albino mice. The ethanol extract of Pseudarthria viscida (EEPV) was administered at the doses of 100 and 200 mg/kg in mice for 14 days after 24 h of tumor inoculation. The effect of EEPV on the growth of transplantable murine tumor, life span of EAC bearing mice, hematological profile and liver biochemical parameters were estimated. Treatment with EEPV decreased the tumor volume and viable cell count thereby increasing the life span of EAC bearing mice and brought back the hematological parameter more or less normal level. The effect of EEPV decreases the level of lipid peroxidation and protein content and significantly increased the level of antioxidant enzymes such as Catalase (CAT), Glutathione (GSH) and Superoxide dismutase (SOD). These observations are suggestive of the protective effect of EEPV against Ehrlich Ascites Carcinoma (EAC).

Keywords

Pseudarthria viscida, Ehrlich Ascites Carcinoma, Hematological Parameter, Antioxidant, Antitumor Activity.

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P. Jaya Preethi ¹, K. Bindu Sree ¹, K. Pavan Kumar ¹, R. Rajavelu ¹, T. Sivakumar ¹

Affiliations
1 Department of Pharmacy, Nandha College of Pharmacy and Research Institute, Koorapalayam Piruvu, Erode-638052, Tamil Nadu, IN

Abstract

In the present study, a series of 4-thiazolidinones and 2-azetidinone derivatives were synthesized by refluxing Schiff bases with different aromatic aldehydes. Schiff bases were synthesized by reaction of nicotinamide with hydrazine hydrate. The chemical structures of the synthesized compounds were confirmed by means of IR, 1H-NMR, mass spectroscopy and elemental analysis. These compounds were screened for anti-tubercular, anti-convulsant anti-bacterial and anti-fungal activities. Anti-Tubercular activity mycobacterium tuberculosis and MIC level of the compounds was less than 6.25 μg/ml. Compound IIIa, IIId, IVa and IVd exhibited good Anti-convulsant activity. Compound IIIa, IIIc IIId, IVa, IVc and IVd exhibited good antibacterial activity on Gram-positive and Gram-negative microorganisms. All the synthesized compounds exhibited good Antifungal activity.

Keywords

Schiff Base, Nicotinamide, Hydrazine Hydrate, Anti-Bacterial, Anti-Fungal, Anti-Tubercular, Anticonvulsant.

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M. Jagadeeswaran ¹, N. Gopal ², T. Sivakumar ¹

Affiliations
1 Department of Pharmaceutical Analysis, Nandha College of Pharmacy, Erode-638052, Tamil Nadu, IN
2 Department of Pharmaceutical Chemistry, Balaji Institute of Pharmaceutical Sciences, Narsampet, Warangal-506331, Andhra Pradesh, IN

Abstract

A simple, selective and rapid reversed phase high performance liquid chromatographic (RP-HPLC) method has been developed for the simultaneous estimation of Amlodipine Besylate and Nebivolol Hydrochloride from their tablet formulation. The method is carried out on a nucleosil C₁₈ (25 cm×4.6 mm) column with the mobile phase consisting of 0.01 M tetra butyl ammonium hydrogen sulphate: acetonitrile (60:40 v/v) and adjusted the pH to 3.0 by using trimethyl amine, at the flow rate of 1.0 ml min^-1. Detection is performed at 264 nm. The retention time of Amlodipine Besylate and Nebivolol Hydrochloride was 2.55 and 5.44 min respectively. The developed method was validated for linearity, accuracy, precision, solution stability, robustness, limit of detection, and limit of quantification. The proposed method can be used for routine analysis of drugs in combined dosage forms.

Keywords

Amlodipine Besylate, Nebivolol Hydrochloride, RP-HPLC, Tablets.

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Ismail ¹, R. Rajavel ¹, M. Ganesh ¹, M. Jagadeeswaran ¹, K. Srinivasan ¹, J. Valarmathi ¹, T. Sivakumar ¹

Affiliations
1 Nandha College of Pharmacy, Division of Pharmaceutical Analysis, Koorapalayam Pirivu, Erode-638052, Tamil Nadu, IN

Abstract

A simple, precise, accurate and rapid HPLC method has been developed, and validated for the determination of Aspirin, Atorvastatin and Pioglitazone simultaneously, in combined dosage form. Acetonitrile and phosphate buffer with pH 3.5 (40%:60% v/v) is used as the mobile phase, 261nm is the detection wavelength for this study. The applicability of the method for simultaneous determination of Aspirin, Atorvastatin and Pioglitazone was verified by the determination of these compounds in marketed tablets. Results of the analysis were validated statistically, and by recovery studies (98.29-101.12%). The recovery and RSD values within the limits given in ICH guide lines method developments indicates that the suitability of proposed methods for the routine determination of these compounds in tablets. The validation parameters: linearity (r>0.996), sensitivity (LOD (1.5-0.7×10^-4 mg ml^-1 and LOQ%x10^-4-1.05×10^-4), accuracy (recoveries:98.29-101.12%)and reproducibility were found to satisfactory. The proposed method can be successfully used to determine the drug contents of marketed formulation.

Keywords

RP-HPLC, Aspirin, Pioglitazone, Atorvastatin.

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T. Sivakumar ¹, T. Anusha ²

Affiliations
1 Department of Computer Science and Engineering, Dr. Mahalingam College of Engineering and Technology, IN
2 Department of Computer Science and Engineering, PSG College of Technology, IN

Abstract

Random numbers play an important and primary role in the use of Cryptography techniques in real time applications. The cryptographic techniques can be easily compromised if the key can be easily guessed. Therefore it is important that the keys are in random and unpredictable in nature. The operating system uses the random numbers to mask passwords and to offer salt and session identifiers. This paper introduces a new software based pseudo random number generation method based on the eye brightness response formula. This function provides a significant change in sensation for minimum required change in signal intensity. The randomness tests are performed to confirm the randomness of the generated random numbers.

Keywords

Cryptography, Pseudo Random Number, Eye Brightness Response, Randomness Test.

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