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T. Prabhakar ¹, P. K. M. Nagarathna ¹, B. S. Vikram ¹

Affiliations
1 Karnataka College of Pharmacy, No.33/2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post Bangalore-64, IN

Abstract

The aim of the present study was to screen the antidiabetic potential of the ischolar_main of Sida cordifolia linn. In the present study, ischolar_main of Sida cordifolia linn was screened for antidiabetic activity. Root powder of Sida cordifolia was subjected to hot continuous extraction (soxhlet) with various solvents like petroleum ether, (40-600° C), chloroform, butanol, butanone and alcohol. Aqueous extract was prepared by cold maceration. After preliminary phytochemical investigation, all the extracts were evaluated for anti diabetic activity after single dose (acute study) and after prolonged treatment (chronic study in alloxan induced diabetic albino rats. Al thel extracts were given orally at a dose of 250mg/Kg b.w. Glibenclamide was used as standard drug (10mg/Kg b.w. P.o). Alcohol butonal, Chloroform, aqueous and butanone showed significant antidiabetic activity in acute as well as prolonged treatment compared to control. Petrolium ether extract did not show significant anti diabetic activity on prolonged treatment. Among all the extracts, alcoholic extracts had more significantly reduced the blood glucose level after single dose and nearly equal to standard glibenclamide after prolonged treatment.

Keywords

Sida cordifolia, Anti Diabetic, Glibenclamide, Alloxan.

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M. Srinu , G. V. Phani Bhushan , Feleke Moges , J. Srilakshmi , G. Sankar , T. Prabhakar , K. Lakshminarayana

Abstract

The objective of the present study was screening of 3-hydroxy-3- methyl glutaryl Co A (HMG Co A) reductase inhibitor producing marine actinomycetes. A total of 65 morphologically different actinomycetes were screened for HMG Co A reductase inhibitor production in a two stage submerged fermentation and evaluated for HMG CoA reductase inhibitor activity by agar diffusion and thin layer chromatography technique using lovostatin as a control. Among 65 marine Actinomycete strains, only one strain produced HMG Co A reductase inhibitor.

Keywords

Lovastatin, Marine Actinomycetes, HMG Co A Reductase Inhibitor.

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P. K. M. Nagarathna ¹, T. Prabhakar ², B. S. Vikram ²

Affiliations
1 Karnataka College of Pharmacy, Bangalore, IN
2 Department of Pharmacology, Karnataka College of Pharmacy, #33\2, Thirumenahalli, Hegde Nagar Main Road, Yelahanka Hobli, Jakkur Post, Bangalore-560064, IN

Abstract

Pongamia pinnata Linn were evaluated by determination of urine volume, electrolyte concentration and diuretic potency in male albino rats. Different concentrations of petroleum ether, and methanol extract (250 mg/kg, 500mg/kg) were orally administered to hydrated rats and their urine out put was immediately measured after 5 h of treatment. Furosamide (10 mg/kg) was used as reference drug while normal saline (0.9%) solution was used as control. The petroleum ether extract exhibited dose dependent diuretic property. The onset of diuretic action was extremely prompt (within 1h) and lasted through out the studied period (upto 5h). The ethanol and petroleum ether extracts caused marked increase in Na⁺., K⁺ and Cl^- level. The result of this experiment suggests that Pongamia pinnata Linn leaves extracts possessed significant diuretic activity in rats.

Keywords

Diuretic Activity, Pongamia pinnata Linn, Ethanol Petroleum Ether Extracts.

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