Informatics Publishing Limited

T. Devasena ¹, K. Ezhilpriya ¹

Affiliations
1 Department of Biotechnology, Mother Teresa Women's University, Kodaikanal - 624 102, Tamil Nadu, IN

Abstract

Vigorous search has been on going in recent years for the means by which the concentration of lipids in the serum can be lowered or maintained within the normal range. Successful methods reported include those based on diets and those based on the use of chemicals to reduce the incidence of high fat diet related diseases like coronary heart disease and atherosclerosis.

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T. Devasena ¹, S. Lalitha ², K. Padma ³

Affiliations
1 Department of Biotechnology, Mother Teresa Women's University, Kodaikanal, Tamil Nadu, IN
2 Department of Obstetrics and Gynaecology, University of Michigan, Michigan, US
3 Department of Paediatrics, Raja Muthaiah Medical College Hospital, Annamalai University, Tamil Nadu, IN

Abstract

Anaemia affects more than 3.5 billion people in developing world in spite of several intervention programmes in which iron tablets are given to children, Anaemia is caused by significant changes in hematological parameters such as Red Blood Cell (RBC) count, haemoglobin, hematocrit, White Blood Cell (WBC) count and Erythrocyte Sedimentation Rate (ESR) which could be used as biomarkers in assessing the severity of several diseases including kidney diseases.

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T. Devasena ¹, S. Lalitha ², K. Padma ³

Affiliations
1 Department of Biochemistry, Annamalai University - 608 002, IN
2 Department of Obstetric and Gynaecology, University of Michigan, Michigan, US
3 Department of Pediatrics, Rajah Muthaiah Medical College, Annamalai University, IN

Abstract

Interest has grown in the role of oxygen derived free radicals such as superoxide anion and hydroxyl radicals as mediator of tissue damage in many disease processes. Lipid peroxidation (LPO) a free radical induced phenomenon was reported to be involved in the pathogenesis of glomerular disease such as nephrotic syndrome and acute poststreptococcal glomerulonephritis (APSGN) in children. APSGN is an inflammatory glomerular disease caused by the (5-hemolytic streptococcal infection of throat and skin. Epidemics of APSGN have been reported in different parts of the world. In APSGN children, blood loses its antioxidant defence and the children might suffer from prolonged oxidative stress with increased susceptibility to LPO and osmotic lysis. Therefore, it is expected that if APSGN children are supplemented with antioxidants along with the conventional antibiotic, it could prove beneficial in the quick amelioration of the disease.

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T. Devasena ¹, S. Lalitha ², K. Padma ³

Affiliations
1 Department of Biochemistry, Annamalai University, Annamalai Nagar, Tamilnadu, IN
2 Department of Obstetric and Gynaecology, University of Michigan, Michigan, US
3 Department of Pediatrics, Rajah Muthiah Medical College and Hospital, Annamalai University, Annamalai Nagar, Tamil Nadu, IN

Abstract

Minimal change nephrotic syndrome (MCNS) is the most common form of glomerular disease in children characterised by massive proteinuria. Corticosteroid therapy is currently recommended by German APN group (Arbeitsgemeinschaft Fur Paediatrische Nephrologie group -1990) for MCNS children. Prednisolone is commonly used for the treatment of MCNS children. However side effects of steroids (cataract, growth retardation, psychological disorders) adds to the morbidity and mortality of nephrotic syndrome patients.

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T. Devasena ¹, T. Ravimycin ²

Affiliations
1 Department of Botany, Annamalai University, Ambattur Study Centre, Chennai (T.N.), IN
2 Department of Biotechnology, Mother Teresa Women’s University, Kodaikanal (T.N.), IN

Abstract

We investigated the antifungal property of gold Nanoparticles coated with ketoconazole against the dandruff causing organism-Malassezia pachydermatis in comparison with pure ketoconazole by disc diffusion method. The diameter of the inhibition zone is greater for gold Nanoparticles coated with ketoconazole than for pure ketoconazole. This shows that gold Nanoparticles enhances the bioactivity of ketoconazole. Zone of inhibition increased with increase in concentration of gold Nanoparticles (0.1 mM<0.2 mM<0.3 mM). We conclude that ketoconazole coated gold Nanoparticles prevent the growth of the dandruff causing organism. The inhibitory power is greater than the pure drug. Thus, gold Nanoparticles can be incorporated along with ketoconazole and formulated into an effective antidandruff shampoo.

Keywords

Nanoparticles, Gold, Dandruff, Ketoconazole, Malassezia.

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T. Devasena ¹

Affiliations
1 Department of Biotechnology, Mother Teresa Women’s University, Kodaikanal (T.N.), IN

Abstract

1,2-dimethylhydrazine (DMH) is a toxic environmental pollutant. Humans are exposed to DMH through rocket fuel and Gyromitra species of mushroom. DMH induced colon tumor in rats mimics human colon tumor in morphological and histological aspects. Thus, DMH model is well established and correlated with human problems.The effects of dietary fenugreek seeds on induced colon tumor and oxidative stress was investigated in male Wistar rats. Rats administered with a weekly subcutaneous injection of DMH (20 mg/kg body weight) for 15 weeks developed colon tumor with 100% incidence, and showed a significant, i) decrease in lipid peroxidation (LPO) measured interms of thiobarbituric acid reactive substances (TBARS), ii) decrease in phospholipid, a major substrate for LPO and iii) increase in glutathione dependent enzymes-glutathione peroxidase (GPx) and glutathione S-transferase (GST), when compared to control rats. However, supplementation of dietary fenugreek to DMH treated rats significantly decreased the tumor incidence to 16.66%, increased the TBARS and phospholipid content and decreased the GPx and GST activities when compared to DMH treated rats. It is suggested that fenugreek act as antitumorigenic agent by influencing DMH induced colon tumor incidence and oxidative stress through its constituents flavonoids, saponin, protease inhibitors and dietary fibre.

Keywords

Fenugreek, Colon Cancer, Phospholipid, Lipid Peroxidation, Glutathione, Mushroom.

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S. Hari Lakshmi ¹, T. Devasena ¹

Affiliations
1 Centre for Nanoscience and Technology, Anna University, Chennai 600 025, IN

Abstract

The present study assesses cubebinol from Piper cubeba as a potential antiviral against SARS-CoV-2, comparing its efficacy to remdesivir. Docking studies show that cubebinol binds more effectively to the spike proteins and papain-like protease of SARS-CoV-2, with binding energies of –5.28, –7.46 and –7.39 kcal/mol respectively. Cubebinol demonstrates superior pharmacokinetics, including higher intestinal absorption and blood-brain barrier penetration, with no significant toxicological issues. The results suggest that cubebinol is a promising candidate for treating SARS-CoV-2 and should be further explored for clinical application

Keywords

Cubebinol, docking, omicron, phytocomponents, SARS-CoV.

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