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Authors
Affiliations
1 Department of Pharmaceutics, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara-
571511,Karnataka, IN
2 Department of Pharmaceutical Chemistry, M.M.U College of Pharmacy, K, K, Doddi, Dist. Ramanagara- 571511, Karnataka, IN
Source
Research Journal of Pharmaceutical Dosage Form and Technology, Vol 1, No 2 (2009), Pagination: 130-134
Abstract
Overactive bladder (OAB) is a chronic and distressing medical condition characterized by urinary urgency and frequency with or without urge incontinence that often requires long term treatment to maintain control of symptoms. Oxybutynin is an anticholinergic drug used to treat OAB. The transdermal films of oxybutynin were formulated using solvent casting technique. Solutions containing polymers (HPMC, Ethyl cellulose) at different concentrations (2%, 3% and 4% w/w) were prepared. These solutions were then used to prepare films. Prepared films were then evaluated for various physicochemical properties like physical appearance, weight variation, thickness, drug content, folding endurance percentage elongation and tensile strength including in vitro studies. Between the two polymers used results showed that the formulation HE2 prepared in combination of HPMC: ethyl cellulose (3:1) with 30% propylene glycol was very flexible with highest folding endurance and uniform drug content. Further permeation study for HE2 shows 88.58% release across the rat abdominal skin for 24 hours.
Keywords
Overactive Bladder, Solvent Casting Technique, Oxybutynin.
