Informatics Publishing Limited

Swati S. Talokar ¹, Rohan R. Vakhariya ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon Tal Walwa, Dist Sangli, Maharashtra, IN

Abstract

Technology transfer is a critical and integral part of drug development process. This path for is dependent on completion of technology transfer to the product site at an affordable cost. The purpose of this review article is to discuss various aspects of technology transfer. This article highlights the goals, importance, facets and various models associated with technology transfer. This article also discuss some of examples of technology transfer in India as well as in global market.

Keywords

Technology Transfer, Facets, Model.

Full Text

     

Rohan R. Vakhariya ¹, Swati S. Talokar ¹, V. R. Salunkhe ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal. Walwa, Dist. Sangli, Maharashtra, IN

Abstract

The present research work support preformulation, formulation, development and optimization of solid lipid nanoparticles containing simvastatin as an antihyperlipidemic drug. The different batches of formulation were obtained using simvastatin as active pharmaceutical ingredient, stearic acid as the source of lipid and β - cyclodextrin as a polymer. Solid lipid nanoparticles of simvastatin were prepared by precipitation method. The prepared formulations were evaluated for various parameters like Particle size, Percentage entrapment efficiency, Measurement of Zeta Potential, FTIR, in-vitro release study. The result was found to be within standard limit. FTIR study reports indicated that there was no interaction between Simvastatin and other excipients. Motic microscope shown that the nanoparticles size ranges from 100-550nm. Percent entrapment efficiency was between 61.40% - 92.30%. Based on the resultants of the entrapment and particle size of nanoparticles, formulation S6 was observed to be optimized formulation. The optimized formulation exhibited 63.75% cumulative drug release after 24 h. The optimized batch shows mean of zeta potential at -44.0 mV.

Keywords

Antihyperlipidemic Drug, β–Cyclodextrin, Entrapment Efficiency, Zeta Potential, Motic Microscope.

Full Text

     

Swati S. Talokar ¹, Rohan R. Vakhariya ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Dist–Sangli Tal–Walwa Maharashtra, IN

Abstract

Microspheres are powders consisting of proteins or synthetic polymers. Microsphere is one approach of delivering active drug ingredient to targeted site. They can overcome the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. Microspheres received much attention for prolonged release as well as for targeting anticancer drugs to the tumor. The present study describes formulation of Lomefloxacin microspheres. In future by combining various other strategies, microspheres will find the central place in novel drug delivery. Formulated microsphere is evaluated for its surface morphology, particle size, in vitro drug release, drug entrapment efficiency. All the results were up to the mark and were found satisfactory.

Keywords

Targeted Site, Carrier, Novel Drug, Entrapment Efficiency.

Full Text

     

Rohan R. Vakhariya ¹, Swati S. Talokar ¹, V. R. Salunkhe ¹, C. S. Magdum ¹

Affiliations
1 Rajarambapu College of Pharmacy, Kasegaon, Tal-Walwa, Dist-Sangli, Maharashtra, IN

Abstract

People with mild cognitive impairment have problems with memory, language, thinking or judgment that are greater than the cognitive changes associated with normal aging. Cognitive disorders can be objectively measured in cognitive tests, but the changes in cognitive abilities are usually not serious enough to interfere with daily life and independence. A person with cognitive impairment has an increased risk of developing Delirium, Dementia Alzheimer's disease and Amnesia, but some people with cognitive impairment remain stable and others show improved cognitive abilities over time. There is no proper cure for the cognitive disorders and much of the treatments available have been able to only delay the progression of the disorders or provide symptomatic relief for a short time period. Therefore there is need for a different approach to the treatment of these cognitive disorders. Different medicinal plants have been used since ancient times in the treatment of various cognitive disorders. Therefore pharmacological screening of medicinal plants may provide useful leads in the discovery of new drugs for the treatment of cognitive disorders. Variety of medicinal plants which can be used in cognitive enhancement is reviewed in this article. Phytochemical substances such as alkaloids, curcuminoids, triterpenoids and withenolides with pharmacological activities related to cognitive disorders treatment are discussed in this review.

Keywords

Cognitive Disorders, Alzheimer’s Disease, Medicinal Plants, Cognitive Enhancement, Phytochemical Substances.

Full Text